Double-networks based on pH-responsive, amphiphilic “core-first” star first polymer conetworks prepared by sequential RAFT polymerization

2017 ◽  
Vol 8 (1) ◽  
pp. 245-259 ◽  
Author(s):  
Elina N. Kitiri ◽  
Costas S. Patrickios ◽  
Chrysovalantis Voutouri ◽  
Triantafyllos Stylianopoulos ◽  
Ingo Hoffmann ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Raft Polymerization ◽  
Amphiphilic Polymer ◽  
Ph Responsive ◽  
Nanophase Separation ◽  
Double Networks

Double-networks based on amphiphilic polymer conetworks synthesized using RAFT polymerization were prepared, exhibiting pH-responsiveness, nanophase separation and enhanced mechanical properties.

Folic acid targeted pH-responsive amphiphilic polymer nanoparticles conjugated with near infrared fluorescence probe for imaging-guided drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (46) ◽  
pp. 40312-40322 ◽  
Author(s):  
Liyi Fu ◽  
Le Liu ◽  
Zheng Ruan ◽  
Houbing Zhang ◽  
Lifeng Yan
Keyword(s):  
Folic Acid ◽  
Ring Opening ◽  
Near Infrared ◽  
Fluorescence Probe ◽  
Click Reaction ◽  
Raft Polymerization ◽  
Ring Opening Polymerization ◽  
Amphiphilic Polymer ◽  
Polymer Nanoparticles ◽  
Ph Responsive

A novel folic acid targeted pH-responsive amphiphilic polymer conjugated with near infrared (NIR) probe has been synthesized by the combination of RAFT polymerization, ring-opening polymerization of N-carboxy anhydride (NCA) and click reaction.

Controlling Mechanical Properties of 3D Printed Polymer Composites through Photoinduced Reversible Addition-Fragmentation Chain Transfer (RAFT) Polymerization

2021 ◽  
Author(s):  
Xiaobing Shi ◽  
Jin Zhang ◽  
Nathaniel Alan Corrigan ◽  
Cyrille Boyer
Keyword(s):  
Mechanical Properties ◽  
Silica Nanoparticles ◽  
Polymer Composites ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Polymer Networks ◽  
Material Design ◽  
Advanced Material ◽  
Reversible Addition ◽  
3D Printed

Reversible addition-fragmentation chain-transfer (RAFT) polymerization has been widely exploited to produce homogeneous and living polymer networks for advanced material design. In this work, we incorporate silica nanoparticles (SNPs) into a...

Lignin and soy oil-derived polymeric biocomposites by “grafting from” RAFT polymerization

2016 ◽  
Vol 18 (18) ◽  
pp. 4974-4981 ◽  
Author(s):  
Yuzhi Xu ◽  
Liang Yuan ◽  
Zhongkai Wang ◽  
Perry A. Wilbon ◽  
Chunpeng Wang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Soybean Oil ◽  
Raft Polymerization ◽  
Soy Oil ◽  
Linear Polymers ◽  
Grafting From

The “grafting from” RAFT enabled synthesis of soybean oil and lignin polymeric biocomposites that exhibit enhanced mechanical properties compared to linear polymers is reported.

scholarly journals Dynamic studies of the interaction of a pH responsive, amphiphilic polymer with a DOPC lipid membrane

Soft Matter ◽  
2017 ◽  
Vol 13 (20) ◽  
pp. 3690-3700 ◽  
Author(s):  
Sivaramakrishnan Ramadurai ◽  
Marco Werner ◽  
Nigel K. H. Slater ◽  
Aaron Martin ◽  
Vladimir A. Baulin ◽  
...  
Keyword(s):  
Lipid Membrane ◽  
Amphiphilic Polymer ◽  
Ph Responsive ◽  
Dynamic Studies

Diazonaphthoquinone-based amphiphilic polymer assemblies for NIR/UV light- and pH-responsive controlled release

2018 ◽  
Vol 9 (4) ◽  
pp. 463-471 ◽  
Author(s):  
Qingwei Li ◽  
Ziquan Cao ◽  
Guojie Wang
Keyword(s):  
Controlled Release ◽  
Uv Light ◽  
Amphiphilic Polymer ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Responsive Polymer ◽  
Self Assembled ◽  
Stimuli Responsive Polymer ◽  
Ph Controlled

A multiple-stimuli-responsive polymer nanocarrier has been self-assembled for NIR/UV light- and pH-controlled cargo release.

Chiral pH-Responsive Amphiphilic Polymer Co-networks: Preparation, Chiral Recognition, and Release Abilities

2013 ◽  
Vol 214 (12) ◽  
pp. 1375-1383 ◽  
Author(s):  
Lu Shi ◽  
Peng Xie ◽  
Zhimin Li ◽  
Youping Wu ◽  
Jianping Deng
Keyword(s):  
Chiral Recognition ◽  
Amphiphilic Polymer ◽  
Ph Responsive

scholarly journals Formaldehyde-Doxorubicin Dual Polymeric Drug Delivery System for Higher Efficacy and Limited Cardiotoxicity of Anthracyclines

2020 ◽  
Author(s):  
Estela Ordonez ◽  
Laken Kendrick-Williams ◽  
EVA HARTH
Keyword(s):  
Delivery System ◽  
Raft Polymerization ◽  
Release Kinetics ◽  
Therapeutic Index ◽  
Ph Responsive ◽  
System Combination ◽  
Polymeric Drug Delivery ◽  
Reversible Addition ◽  
Tumor Environment ◽  
Polymeric Delivery

<p>We report the synthesis of a dual delivery system composed of a chemically bound pH-responsive formaldehyde polymer prodrug and pH-responsive doxorubicin loaded nanoparticles to increase the therapeutic index of anthracyclines by limiting the cardiotoxicity of doxocrubicin by working in synergy with formaldehyde to enable the formation of DOX-DNA adducts. Polyacrylates bearing 1,2- and 1,3- pendant diols were synthesized via reversible addition fragmentation chain transfer (RAFT) polymerization to conjugate formaldehyde, forming 5- or 6-membered acetal rings with tunable conjugation percentages (1.5 – 10 wt%) for controlled release in acidic environments of the tumor extracellular matrix. The formaldehyde-conjugated prodrugs are then combined with polyester nanoparticles formed by intermolecular crosslinking via oxime click chemistry of less than 200 nm in size containing 14 wt% encapsulated Doxorubicin (DOX). Release kinetics show a sustained release of both DOX and formaldehyde at pH 5.0, mimicking the low pH of the tumor environment whereas insignificant release was recorded at physiological pH. The cell viability of the dual delivery system combination was evaluated in 4 T1 breast cancer cells resulting in a considerably increase of cell death of about 4-fold compared to free DOX alone. The resulting polymeric delivery system is the first example reported of a DOX and formaldehyde co-administration, demonstrating the potential significant effect of formaldehyde for an improved anti-cancer efficacy of DOX and towards a reduced cardiotoxicity of DOX.</p>

Biomedical Applications of pH-Responsive Amphiphilic Polymer Nanoassemblies

2020 ◽  
Vol 3 (3) ◽  
pp. 2104-2117 ◽  
Author(s):  
Shivshankar R. Mane ◽  
Ashlin Sathyan ◽  
Raja Shunmugam
Keyword(s):  
Biomedical Applications ◽  
Amphiphilic Polymer ◽  
Ph Responsive
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