scholarly journals pH-Responsive nanodrug encapsulated by tannic acid complex for controlled drug delivery

RSC Advances ◽  
2017 ◽  
Vol 7 (5) ◽  
pp. 2829-2835 ◽  
Author(s):  
Huan Huang ◽  
Ping Li ◽  
Changliang Liu ◽  
Huailei Ma ◽  
He Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antitumor Activity ◽  
Drug Release ◽  
Metal Ions ◽  
Tannic Acid ◽  
Controlled Drug Delivery ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Acid Complex ◽  
Release Property

Metal ions/polyphenol complexes encapsulated paclitaxel nanodrug with high pH-sensitive drug release property and enhanced antitumor activity was obtained.

Composite microparticle drug delivery systems based on chitosan, alginate and pectin with improved pH-sensitive drug release property

2009 ◽  
Vol 68 (2) ◽  
pp. 245-249 ◽  
Author(s):  
Cui-Yun Yu ◽  
Bo-Cheng Yin ◽  
Wei Zhang ◽  
Si-Xue Cheng ◽  
Xian-Zheng Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ph Sensitive ◽  
Release Property

pH-Responsive polymeric Janus containers for controlled drug delivery

2015 ◽  
Vol 6 (22) ◽  
pp. 4144-4153 ◽  
Author(s):  
Ziguang Zhao ◽  
Feiyan Zhu ◽  
Xiaozhong Qu ◽  
Qiuhua Wu ◽  
Qian Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Hollow Spheres ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Ph Responsive

In this study, we have successfully designed and fabricated pH-responsive polymeric Janus hollow spheres for controlled drug release.

scholarly journals TEMPO-Oxidized Cellulose Beads as Potential pH-Responsive Carriers for Site-Specific Drug Delivery in the Gastrointestinal Tract

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1030
Author(s):  
Fan Xie ◽  
Pieter De Wever ◽  
Pedro Fardim ◽  
Guy Van den Mooter
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Release Rate ◽  
Release Kinetics ◽  
Drug Loading ◽  
Controlled Drug Delivery ◽  
Oxidized Cellulose ◽  
Ph Responsive ◽  
Renewable Materials ◽  
Degree Of Oxidation

The development of controlled drug delivery systems based on bio-renewable materials is an emerging strategy. In this work, a controlled drug delivery system based on mesoporous oxidized cellulose beads (OCBs) was successfully developed by a facile and green method. The introduction of the carboxyl groups mediated by the TEMPO(2,2,6,6-tetramethylpiperidine-1-oxyradical)/NaClO/NaClO2 system presents the pH-responsive ability to cellulose beads, which can retain the drug in beads at pH = 1.2 and release at pH = 7.0. The release rate can be controlled by simply adjusting the degree of oxidation to achieve drug release at different locations and periods. A higher degree of oxidation corresponds to a faster release rate, which is attributed to a higher degree of re-swelling and higher hydrophilicity of OCBs. The zero-order release kinetics of the model drugs from the OCBs suggested a constant drug release rate, which is conducive to maintaining blood drug concentration, reducing side effects and administration frequency. At the same time, the effects of different model drugs and different drug-loading solvents on the release behavior and the physical state of the drugs loaded in the beads were studied. In summary, the pH-responsive oxidized cellulose beads with good biocompatibility, low cost, and adjustable release rate have shown great potential in the field of controlled drug release.

scholarly journals Dual stimuli-responsive polyphosphazene-based molecular gates for controlled drug delivery in lung cancer cells

RSC Advances ◽  
2020 ◽  
Vol 10 (46) ◽  
pp. 27305-27314
Author(s):  
Yolanda Salinas ◽  
Michael Kneidinger ◽  
Cristina Fornaguera ◽  
Salvador Borrós ◽  
Oliver Brüggemann ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Bottle Brush ◽  
Molecular Gates

Bottle-brush polyphosphazenes as dual, thermosensitive and pH responsive gatekeepers for mesoporous silica nanoparticles, and their use in controlled drug release.

scholarly journals Strategy to design a smart photocleavable and pH sensitive chitosan based hydrogel through a novel crosslinker: a potential vehicle for controlled drug delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (25) ◽  
pp. 14694-14704 ◽  
Author(s):  
Safiya Nisar ◽  
Ashiq Hussain Pandit ◽  
Li-Fang Wang ◽  
Sunita Rattan
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Ph Sensitive ◽  
Stimuli Responsive ◽  
Ph Responsive

We report the synthesis of a novel photocleavable crosslinker and its joining with amine-based polysachharides, viz. chitosan, resulting in the formation of a dual stimuli-responsive hydrogel having UV- and pH-responsive sites.

Acetalated-dextran as valves of mesoporous silica particles for pH responsive intracellular drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (13) ◽  
pp. 9546-9555 ◽  
Author(s):  
Zhe Lin ◽  
Jizhen Li ◽  
Hongyan He ◽  
Huihui Kuang ◽  
Xuesi Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Anticancer Drugs ◽  
Silica Particles ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Release System ◽  
Intracellular Drug Delivery ◽  
Intracellular Release

A pH-sensitive drug release system using acetalated-dextran as valves was designed to manipulate smart intracellular release of anticancer drugs.

Design of yolk–shell Fe3O4@PMAA composite microspheres for adsorption of metal ions and pH-controlled drug delivery

2014 ◽  
Vol 2 (19) ◽  
pp. 7065-7074 ◽  
Author(s):  
Linling Zhao ◽  
Huarong Liu ◽  
Fengwei Wang ◽  
Lai Zeng
Keyword(s):  
Drug Delivery ◽  
Metal Ions ◽  
Emulsion Polymerization ◽  
Sol Gel ◽  
Controlled Drug Delivery ◽  
Core Shell ◽  
Ph Responsive ◽  
Composite Microspheres ◽  
Adsorption Of Metal Ions ◽  
Hydrolysis Of

Yolk–shell structured pH-responsive Fe3O4@PMAA microspheres have been prepared for adsorption of metal ions and drug delivery by combined sol–gel reaction, emulsion polymerization and selective etching methods accompanying hydrolysis of PMMA shells of core–shell–shell Fe3O4@SiO2@PMMA composite microspheres.

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

A general method to greatly enhance ultrasound-responsiveness for common polymeric assemblies

2020 ◽  
Vol 11 (19) ◽  
pp. 3296-3304
Author(s):  
Jinkang Dou ◽  
Ruiqi Yang ◽  
Kun Du ◽  
Li Jiang ◽  
Xiayun Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Promising Technique ◽  
Polymeric Assemblies ◽  
General Method

Ultrasound-controlled drug release is a very promising technique for controlled drug delivery due to the unique advantages of ultrasound as the stimulus.

Sign in / Sign up

Export Citation Format

Share Document