pH-Responsive polymeric Janus containers for controlled drug delivery

2015 ◽  
Vol 6 (22) ◽  
pp. 4144-4153 ◽  
Author(s):  
Ziguang Zhao ◽  
Feiyan Zhu ◽  
Xiaozhong Qu ◽  
Qiuhua Wu ◽  
Qian Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Hollow Spheres ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Ph Responsive

In this study, we have successfully designed and fabricated pH-responsive polymeric Janus hollow spheres for controlled drug release.

scholarly journals Dual stimuli-responsive polyphosphazene-based molecular gates for controlled drug delivery in lung cancer cells

RSC Advances ◽  
2020 ◽  
Vol 10 (46) ◽  
pp. 27305-27314
Author(s):  
Yolanda Salinas ◽  
Michael Kneidinger ◽  
Cristina Fornaguera ◽  
Salvador Borrós ◽  
Oliver Brüggemann ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Bottle Brush ◽  
Molecular Gates

Bottle-brush polyphosphazenes as dual, thermosensitive and pH responsive gatekeepers for mesoporous silica nanoparticles, and their use in controlled drug release.

A general method to greatly enhance ultrasound-responsiveness for common polymeric assemblies

2020 ◽  
Vol 11 (19) ◽  
pp. 3296-3304
Author(s):  
Jinkang Dou ◽  
Ruiqi Yang ◽  
Kun Du ◽  
Li Jiang ◽  
Xiayun Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Promising Technique ◽  
Polymeric Assemblies ◽  
General Method

Ultrasound-controlled drug release is a very promising technique for controlled drug delivery due to the unique advantages of ultrasound as the stimulus.

Water based PHEMA hydrogels for controlled drug delivery

2017 ◽  
Vol 43 (3) ◽  
pp. 228-239
Author(s):  
Hakan Ayhan ◽  
Fatma Ayhan
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Bacterial Strains ◽  
Buffer Solutions ◽  
Free Radical Photopolymerization ◽  
Water Based ◽  
Hydrogel Swelling ◽  
Drug Activities

Abstract Objective: In the scope of presented work, synthesis of water based acrylate hydrogels, characterization, and their usage in controlled drug release systems were aimed to investigate. Methods: Synthesis of acrylate based hydrogels that have different properties was carried out by free radical photopolymerization using photoinitiator. Because of its high biocompatibility, 2-hydroxyethyl metacrylate (HEMA) was used as monomer. Then drug release experiments were performed in pH 7.4 and 1.2 buffer solutions with certain ionic strength while the dynamic swelling behaviors were also determined. In the last part of the work, drug activities of synthesized drug-loaded hydrogels were tested in mediums containing Staphylococcus aureus and Pseudomonas aeruginosa bacteria cultures. Results: ATR-FTIR spectrums of all synthesized hydrogels were analyzed. The characteristic O-H, C-H, C=O, C-O tension vibrations bands were observed in the spectrums of the hydrogels. The rate of drug release in acidic pH 1.2 for two types of hydrogels was observed to be much faster than at pH 7.4. It was determined that hydrogel swelling ratio decrease with increasing monomer ratio. All drug loaded hydrogels were effective to inhibit the growth of both two bacterial strains. Conclusion: Hydrogels synthesized were found to be suitable for the controlled drug delivery applications.

Polymer–paclitaxel conjugates based on disulfide linkers for controlled drug release

RSC Advances ◽  
2015 ◽  
Vol 5 (10) ◽  
pp. 7559-7566 ◽  
Author(s):  
Wulian Chen ◽  
Luqman Ali Shah ◽  
Li Yuan ◽  
Mohammad Siddiq ◽  
Jianhua Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Diblock Copolymer ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Controlled Drug Delivery System ◽  
Disulfide Linkers ◽  
Covalently Linked

Controlled drug delivery system based on hydrophilic diblock copolymer covalently linked paclitaxel (PTX) via a disulfide linker.

scholarly journals TEMPO-Oxidized Cellulose Beads as Potential pH-Responsive Carriers for Site-Specific Drug Delivery in the Gastrointestinal Tract

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1030
Author(s):  
Fan Xie ◽  
Pieter De Wever ◽  
Pedro Fardim ◽  
Guy Van den Mooter
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Release Rate ◽  
Release Kinetics ◽  
Drug Loading ◽  
Controlled Drug Delivery ◽  
Oxidized Cellulose ◽  
Ph Responsive ◽  
Renewable Materials ◽  
Degree Of Oxidation

The development of controlled drug delivery systems based on bio-renewable materials is an emerging strategy. In this work, a controlled drug delivery system based on mesoporous oxidized cellulose beads (OCBs) was successfully developed by a facile and green method. The introduction of the carboxyl groups mediated by the TEMPO(2,2,6,6-tetramethylpiperidine-1-oxyradical)/NaClO/NaClO2 system presents the pH-responsive ability to cellulose beads, which can retain the drug in beads at pH = 1.2 and release at pH = 7.0. The release rate can be controlled by simply adjusting the degree of oxidation to achieve drug release at different locations and periods. A higher degree of oxidation corresponds to a faster release rate, which is attributed to a higher degree of re-swelling and higher hydrophilicity of OCBs. The zero-order release kinetics of the model drugs from the OCBs suggested a constant drug release rate, which is conducive to maintaining blood drug concentration, reducing side effects and administration frequency. At the same time, the effects of different model drugs and different drug-loading solvents on the release behavior and the physical state of the drugs loaded in the beads were studied. In summary, the pH-responsive oxidized cellulose beads with good biocompatibility, low cost, and adjustable release rate have shown great potential in the field of controlled drug release.

Fe3O4@carbon@zeolitic imidazolate framework-8 nanoparticles as multifunctional pH-responsive drug delivery vehicles for tumor therapy in vivo

2015 ◽  
Vol 3 (46) ◽  
pp. 9033-9042 ◽  
Author(s):  
Mengni He ◽  
Jiajia Zhou ◽  
Jian Chen ◽  
Fangcai Zheng ◽  
Dongdong Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Tumor Therapy ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Zeolitic Imidazolate Framework ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Controlled drug release is a promising approach for cancer therapy due to its merits of reduced systemic toxicity and enhanced antitumor efficacy.

Stimulus-cleavable chemistry in the field of controlled drug delivery

2021 ◽  
Author(s):  
Yufei Xue ◽  
Hua Bai ◽  
Bo Peng ◽  
Bin Fang ◽  
Jonathan Baell ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Research Areas ◽  
Potential Applications

This review comprehensively summarises stimulus-cleavable linkers from various research areas and their cleavage mechanisms, thus provides an insightful guideline to extend their potential applications to controlled drug release from nanomaterials.

pH-responsive cancer-targeted selenium nanoparticles: a transformable drug carrier with enhanced theranostic effects

2014 ◽  
Vol 2 (33) ◽  
pp. 5409-5418 ◽  
Author(s):  
Bo Yu ◽  
Xiaoling Li ◽  
Wenjie Zheng ◽  
Yanxian Feng ◽  
Yum-Shing Wong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Cell Organelles ◽  
Shape Transformation ◽  
Anticancer Efficacy

A cancer-targeted and structure-transformable drug delivery system has been constructed, which displays enhanced anticancer efficacy and exhibits the characteristics of shape transformation and pH-controlled drug release under acidifying cell organelles.

scholarly journals NIR-triggered upconversion nanoparticles@thermo-sensitive liposome hybrid theranostic nanoplatform for controlled drug delivery

RSC Advances ◽  
2021 ◽  
Vol 11 (46) ◽  
pp. 29065-29072
Author(s):  
Yibin Yu ◽  
Yida Huang ◽  
Wanqian Feng ◽  
Mei Yang ◽  
Baiqi Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Upconversion Luminescence ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Upconversion Nanoparticles

A novel hybrid photothermal theranostic nanoplatform UCNPs@Bi@SiO2@GE HP-lips is developed. Upon NIR irradiation, the nanoplatform could photothermally trigger controlled drug release and present bright upconversion luminescence.

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