Chitosan coated gold nanorod chelating gadolinium for MRI-visible photothermal therapy of cancer

RSC Advances ◽  
2016 ◽  
Vol 6 (112) ◽  
pp. 111337-111344 ◽  
Author(s):  
Chunyang Zhang ◽  
Fang Zhang ◽  
Wei Wang ◽  
Jie Liu ◽  
Ming Xu ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Photothermal Therapy ◽  
Gold Nanorod ◽  
Multifunctional Nanoparticles

The multifunctional nanoparticles synthesized via nonsolvent counterion complexation method are applied for in vivo MR imaging and photothermal therapy of cancer.

Coordination polymer hybridized Au nanocages: a nanoplatform for dual-modality imaging guided near-infrared driven photothermal therapy in vivo

2017 ◽  
Vol 5 (44) ◽  
pp. 8761-8769 ◽  
Author(s):  
Congyang Yan ◽  
Lili Cui ◽  
Qi Yang ◽  
Xiaobao Zhou ◽  
Lixing Pan ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Coordination Polymer ◽  
Mr Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Dual Modality ◽  
Dual Modality Imaging

Coordination polymer hybridized Au nanocages (AuNC@CPs) were prepared, which were used for near-infrared (NIR)-driven photothermal therapy (PTT) guided by photoacoustic (PA) and magnetic resonance (MR) imaging in vivo.

Gold Nanorod−Photosensitizer Complex for Near-Infrared Fluorescence Imaging and Photodynamic/Photothermal Therapy In Vivo

ACS Nano ◽  
2011 ◽  
Vol 5 (2) ◽  
pp. 1086-1094 ◽  
Author(s):  
Boseung Jang ◽  
Jin-Young Park ◽  
Ching-Hsuan Tung ◽  
In-Hoo Kim ◽  
Yongdoo Choi
Keyword(s):  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Gold Nanorod ◽  
Near Infrared Fluorescence ◽  
Near Infrared Fluorescence Imaging

Tumor Regression In Vivo by Photothermal Therapy Based on Gold-Nanorod-Loaded, Functional Nanocarriers

ACS Nano ◽  
2011 ◽  
Vol 5 (3) ◽  
pp. 1995-2003 ◽  
Author(s):  
Won Il Choi ◽  
Ja-Young Kim ◽  
Chul Kang ◽  
Clare C. Byeon ◽  
Young Ha Kim ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Regression ◽  
Gold Nanorod

DNA-Nanostructure-Gold-Nanorod Hybrids for Enhanced In Vivo Optoacoustic Imaging and Photothermal Therapy

2016 ◽  
Vol 28 (45) ◽  
pp. 10000-10007 ◽  
Author(s):  
Yang Du ◽  
Qiao Jiang ◽  
Nicolas Beziere ◽  
Linlin Song ◽  
Qian Zhang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Gold Nanorod ◽  
Optoacoustic Imaging ◽  
Dna Nanostructure

scholarly journals In vitro and in vivo MRI imaging and photothermal therapeutic properties of Hematite (α-Fe2O3) Nanorods

2022 ◽  
Vol 33 (1) ◽  
Author(s):  
Aanisa Gulzar ◽  
Nowsheena Ayoub ◽  
Jaffar Farooq Mir ◽  
Amer M. Alanazi ◽  
M. A. Shah ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Photothermal Therapy ◽  
Imaging Techniques ◽  
Mri Imaging ◽  
Mri Contrast ◽  
Therapy Effect ◽  
Therapeutic Properties ◽  
Prepared Nanorods

AbstractHerein we report synthesis of hematite (α-Fe2O3) nanorods by calcinating hydrothermally synthesized goethite nanorods at 5000C. The structural, optical and MRI imaging guided cancer therapeutic properties of fabricated nanorods have been discussed in this manscript. FESEM and TEM imaging techniques were used to confirm the nanorod like morphology of as prepared materials. As we know that Fe2O3 nanorods with size in the range of 25–30 nm exhibit super magnetism. After coating with the PEG, the as prepared nanorods can be used as T2 MR imaging contrast agents. An excellent T2 MRI contrast of 38.763 mM–1s–1 achieved which is highest reported so far for α-Fe2O3. Besides the as prepared nanorods display an excellent photothermal conversion efficiency of 39.5% thus acts as an excellent photothermal therapeutic agent. Thus, we envision the idea of testing our nanorods for photothermal therapy and MR imaging application both in vitro and in vivo, achieving an excellent T2 MRI contrast and photothermal therapy effect with as prepared PEGylated nanorods.

MicroCT Imaging and In Vivo Temperature Elevations in Implanted Prostatic Tumors in Laser Photothermal Therapy Using Gold Nanorods

2012 ◽  
Vol 3 (2) ◽  
Author(s):  
N. Manuchehrabadi ◽  
A. Attaluri ◽  
H. Cai ◽  
R. Edziah ◽  
E. Lalanne ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Imaging System ◽  
Laser Energy ◽  
Gold Nanorod ◽  
Laser Irradiance ◽  
Theoretical Simulation ◽  
Microct Imaging ◽  
Laser Photothermal Therapy

In this study, in vivo animal experiments are performed on implanted xenograph prostatic tumors in nude mice to investigate enhanced laser energy absorption in the tumors by an intratumoral injection of gold nanorod solutions. In vivo temperature mapping of the tumors during laser photothermal therapy has shown the feasibility of elevating tumor temperatures higher than 50 °C using only 0.1 ml nanorod solution and a low laser irradiance of 1.6 W/cm2 incident on the tumor surface. The temperature profile suggests that normal tumor tissue still absorbs some amount of the laser energy without nanorod presence; however, the injected nanorods ensure that almost all the laser energy is absorbed and confined to the targeted tumors. The inverse relationship between the temperature elevations and the tumor size implies a relatively uniform spreading of the nanorods to the entire tumor, which is also shown by microcomputed tomography (microCT) imaging analyses. The feasibility of detecting 250 OD gold nanorod solution injected to the tumors is demonstrated via a high resolution microCT imaging system. Compared to other nanostructures, the gold nanorods used in this study do not accumulate surrounding the injection site. The relatively uniform deposition of the nanorods in the tumors observed by the microCT scans can be helpful in future study in simplifying theoretical simulation of temperature elevations in tumors during laser photothermal therapy.

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