Gold Nanorod−Photosensitizer Complex for Near-Infrared Fluorescence Imaging and Photodynamic/Photothermal Therapy In Vivo

ACS Nano ◽  
2011 ◽  
Vol 5 (2) ◽  
pp. 1086-1094 ◽  
Author(s):  
Boseung Jang ◽  
Jin-Young Park ◽  
Ching-Hsuan Tung ◽  
In-Hoo Kim ◽  
Yongdoo Choi
Keyword(s):  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Gold Nanorod ◽  
Near Infrared Fluorescence ◽  
Near Infrared Fluorescence Imaging

Multifunctional A7R Peptide-Modified Hollow Mesoporous Silica@Ag2S Nanotheranostics for Photoacoustic/Near-Infrared Fluorescence Imaging-Guided Tumor-Targeted Chemo-Photothermal Therapy

2019 ◽  
Vol 15 (7) ◽  
pp. 1415-1431 ◽  
Author(s):  
Jianrong Wu ◽  
David H. Bremner ◽  
Shiwei Niu ◽  
Dejian Li ◽  
Ranran Tang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Mesoporous Silica Nanoparticles ◽  
Photothermal Effect ◽  
Near Infrared Fluorescence ◽  
Hollow Mesoporous Silica ◽  
Near Infrared Fluorescence Imaging

The fabrication of theranostic nanoplatforms which combine diagnostic and therapeutic functions have become an emerging approach for personal nanomedicine. Herein, a multifunctional nanoplatform consisting of A7R peptide (ATWLPPR) conjugated hollow mesoporous silica nanoparticles decorated with Ag2S nanodots (Ag2S@HMSs-A7R) has been developed as an efficient theranostic agent for simultaneous photoacoustic (PA) imaging and near-infrared fluorescence imaging (NIRF)-guided targeted chemotherapy and photothermal therapy against human breast cancer MDA-MB-231 cells. The design of Ag2S doped HMSs by in situ controlled growth of ultrasmall Ag2S nanodots in the mesopores of HMSs. The synthesized multifunctional nanoplatform exhibits high doxorubicin (DOX) loading capability (451 mg/g) and can be precisely controlled by glutathione (GSH), acidic environment and external laser irradiation. Thanks to the strong tunable NIR absorbance of Ag2S, the nanoplatform produce effective photoacoustic capacity and superb photothermal conversion under light irradiation, thereby exhibiting sufficient in vivo fluorescence and photoacoustic signals as well as desirable photothermal therapeutic performance. Importantly, A7R peptide can selectively bind the Neuropilin-1 (NRP-1) receptor which overexpressed by the MDA-MB-231 cells. The achieved Ag2S@HMSs-A7R possess ideal imaging capability for both PA and NIRF imaging in vivo, and the anti-tumor effect of Ag2S@HMSs(DOX)-A7R was studied in vitro and in vivo, showing remarkable synergistic chemo-photothermal effect (combination index, CI < 1). Over all, the strategy of utilizing triple-responsive nanocarriers presents a highly promising potential as an efficient method for cancer theranostics.

A novel antibody targeting CD24 and hepatocellular carcinoma in vivo by near-infrared fluorescence imaging

Immunobiology ◽  
2015 ◽  
Vol 220 (12) ◽  
pp. 1328-1336 ◽  
Author(s):  
Hua He ◽  
Xiaojie Tu ◽  
Juan Zhang ◽  
Desmond Omane Acheampong ◽  
Li Ding ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Antibody Targeting ◽  
Near Infrared Fluorescence Imaging

scholarly journals Endoglin based in vivo near-infrared fluorescence imaging of tumor models in mice using activatable liposomes

2018 ◽  
Vol 1862 (6) ◽  
pp. 1389-1400 ◽  
Author(s):  
Felista L. Tansi ◽  
Ronny Rüger ◽  
Ansgar M. Kollmeier ◽  
Markus Rabenhold ◽  
Frank Steiniger ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Near Infrared ◽  
Tumor Models ◽  
Near Infrared Fluorescence ◽  
Near Infrared Fluorescence Imaging

scholarly journals Extra Domain B Fibronectin as a Target for Near-Infrared Fluorescence Imaging of Rheumatoid Arthritis Affected Joints In Vivo

2009 ◽  
Vol 8 (6) ◽  
pp. 7290.2009.00030 ◽  
Author(s):  
Sonja Vollmer ◽  
Axel Vater ◽  
Kai Licha ◽  
Ines Gemeinhardt ◽  
Ole Gemeinhardt ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Near Infrared Fluorescence Imaging

scholarly journals Computed tomography for in vivo deep over‐1000 nm near‐infrared fluorescence imaging

2020 ◽  
Vol 13 (8) ◽  
Author(s):  
Masakazu Umezawa ◽  
Toshihiro Sera ◽  
Hideo Yokota ◽  
Maho Takematsu ◽  
Masahiko Morita ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Near Infrared Fluorescence Imaging

In vivo near-infrared fluorescence imaging of FAP-expressing tumors with activatable FAP-targeted, single-chain Fv-immunoliposomes

2014 ◽  
Vol 186 ◽  
pp. 1-10 ◽  
Author(s):  
Ronny Rüger ◽  
Felista L. Tansi ◽  
Markus Rabenhold ◽  
Frank Steiniger ◽  
Roland E. Kontermann ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Near Infrared ◽  
Single Chain ◽  
Near Infrared Fluorescence ◽  
Single Chain Fv ◽  
Near Infrared Fluorescence Imaging
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