DNA-Nanostructure-Gold-Nanorod Hybrids for Enhanced In Vivo Optoacoustic Imaging and Photothermal Therapy

2016 ◽  
Vol 28 (45) ◽  
pp. 10000-10007 ◽  
Author(s):  
Yang Du ◽  
Qiao Jiang ◽  
Nicolas Beziere ◽  
Linlin Song ◽  
Qian Zhang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Gold Nanorod ◽  
Optoacoustic Imaging ◽  
Dna Nanostructure

Gold Nanorod−Photosensitizer Complex for Near-Infrared Fluorescence Imaging and Photodynamic/Photothermal Therapy In Vivo

ACS Nano ◽  
2011 ◽  
Vol 5 (2) ◽  
pp. 1086-1094 ◽  
Author(s):  
Boseung Jang ◽  
Jin-Young Park ◽  
Ching-Hsuan Tung ◽  
In-Hoo Kim ◽  
Yongdoo Choi
Keyword(s):  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Gold Nanorod ◽  
Near Infrared Fluorescence ◽  
Near Infrared Fluorescence Imaging

Tumor Regression In Vivo by Photothermal Therapy Based on Gold-Nanorod-Loaded, Functional Nanocarriers

ACS Nano ◽  
2011 ◽  
Vol 5 (3) ◽  
pp. 1995-2003 ◽  
Author(s):  
Won Il Choi ◽  
Ja-Young Kim ◽  
Chul Kang ◽  
Clare C. Byeon ◽  
Young Ha Kim ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Regression ◽  
Gold Nanorod

Chitosan coated gold nanorod chelating gadolinium for MRI-visible photothermal therapy of cancer

RSC Advances ◽  
2016 ◽  
Vol 6 (112) ◽  
pp. 111337-111344 ◽  
Author(s):  
Chunyang Zhang ◽  
Fang Zhang ◽  
Wei Wang ◽  
Jie Liu ◽  
Ming Xu ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Photothermal Therapy ◽  
Gold Nanorod ◽  
Multifunctional Nanoparticles

The multifunctional nanoparticles synthesized via nonsolvent counterion complexation method are applied for in vivo MR imaging and photothermal therapy of cancer.

scholarly journals Optoacoustic imaging of gold nanorod based photothermal therapy

2021 ◽  
Author(s):  
Mehrnaz Tabibi
Keyword(s):  
Acoustic Waves ◽  
Photothermal Therapy ◽  
Pressure Rise ◽  
Gold Nanorod ◽  
Invasive Technique ◽  
Optoacoustic Imaging ◽  
Time Resolved ◽  
Short Pulses ◽  
Normal Tissues ◽  
Commercial Device

Gold Nanorod Photothermal Therapy (GNR-PTT) is a minimally invasive technique and an alternative to surgery for destroying tumors while sparing normal tissues. Gold Nanorods (GNRs) with strong extinction peaks in the near infra-red (NIR) spectrum is a good candidate to convert light into thermal energy to destroy tumors. Opto-acoustic imaging (OAI) is a non-invasive method that detects time-resolved acoustic waves created by short pulses of NIR in tissue. It leads to a pressure rise in the irradiated volume. The question of whether OAI is a suitable candidate for temperature monitoring of GNR-PTT in the NIR spectrum was examined. In this thesis, for the first time, GNRs in a gel phantom was used to monitor the temperature during PTT with different laser powers and GNR concentrations. The imaging was performed by a commercial device IMAGIO, Seno, TX. The results show changes of the OA signal follow to temperature changes. The concentration of GNR and the power have a significant role in producing good results.

Optoacoustic imaging of gold nanorod based photothermal therapy

2021 ◽  
Author(s):  
Mehrnaz Tabibi
Keyword(s):  
Acoustic Waves ◽  
Photothermal Therapy ◽  
Pressure Rise ◽  
Gold Nanorod ◽  
Invasive Technique ◽  
Optoacoustic Imaging ◽  
Time Resolved ◽  
Short Pulses ◽  
Normal Tissues ◽  
Commercial Device

Gold Nanorod Photothermal Therapy (GNR-PTT) is a minimally invasive technique and an alternative to surgery for destroying tumors while sparing normal tissues. Gold Nanorods (GNRs) with strong extinction peaks in the near infra-red (NIR) spectrum is a good candidate to convert light into thermal energy to destroy tumors. Opto-acoustic imaging (OAI) is a non-invasive method that detects time-resolved acoustic waves created by short pulses of NIR in tissue. It leads to a pressure rise in the irradiated volume. The question of whether OAI is a suitable candidate for temperature monitoring of GNR-PTT in the NIR spectrum was examined. In this thesis, for the first time, GNRs in a gel phantom was used to monitor the temperature during PTT with different laser powers and GNR concentrations. The imaging was performed by a commercial device IMAGIO, Seno, TX. The results show changes of the OA signal follow to temperature changes. The concentration of GNR and the power have a significant role in producing good results.

MicroCT Imaging and In Vivo Temperature Elevations in Implanted Prostatic Tumors in Laser Photothermal Therapy Using Gold Nanorods

2012 ◽  
Vol 3 (2) ◽  
Author(s):  
N. Manuchehrabadi ◽  
A. Attaluri ◽  
H. Cai ◽  
R. Edziah ◽  
E. Lalanne ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Imaging System ◽  
Laser Energy ◽  
Gold Nanorod ◽  
Laser Irradiance ◽  
Theoretical Simulation ◽  
Microct Imaging ◽  
Laser Photothermal Therapy

In this study, in vivo animal experiments are performed on implanted xenograph prostatic tumors in nude mice to investigate enhanced laser energy absorption in the tumors by an intratumoral injection of gold nanorod solutions. In vivo temperature mapping of the tumors during laser photothermal therapy has shown the feasibility of elevating tumor temperatures higher than 50 °C using only 0.1 ml nanorod solution and a low laser irradiance of 1.6 W/cm2 incident on the tumor surface. The temperature profile suggests that normal tumor tissue still absorbs some amount of the laser energy without nanorod presence; however, the injected nanorods ensure that almost all the laser energy is absorbed and confined to the targeted tumors. The inverse relationship between the temperature elevations and the tumor size implies a relatively uniform spreading of the nanorods to the entire tumor, which is also shown by microcomputed tomography (microCT) imaging analyses. The feasibility of detecting 250 OD gold nanorod solution injected to the tumors is demonstrated via a high resolution microCT imaging system. Compared to other nanostructures, the gold nanorods used in this study do not accumulate surrounding the injection site. The relatively uniform deposition of the nanorods in the tumors observed by the microCT scans can be helpful in future study in simplifying theoretical simulation of temperature elevations in tumors during laser photothermal therapy.

scholarly journals Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Songtao Zhang ◽  
Longhai Jin ◽  
Jianhua Liu ◽  
Yang Liu ◽  
Tianqi Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Bovine Serum Albumin ◽  
Synergistic Effect ◽  
Bovine Serum ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Photothermal Effect ◽  
Reaction Efficiency

AbstractIn spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin (FeO/MoS2-BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS2 nanosheets triggered by the second near-infrared (NIR II) light. In the tumor microenvironments, the MoS2 nanosheets not only can accelerate the conversion of Fe3+ ions to Fe2+ ions by Mo4+ ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.

Core-Shell Pd@Au Nanoplates as Theranostic Agents for In-Vivo Photoacoustic Imaging, CT Imaging, and Photothermal Therapy

2014 ◽  
Vol 26 (48) ◽  
pp. 8210-8216 ◽  
Author(s):  
Mei Chen ◽  
Shaoheng Tang ◽  
Zhide Guo ◽  
Xiaoyong Wang ◽  
Shiguang Mo ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Ct Imaging ◽  
Core Shell ◽  
Theranostic Agents
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