Photodegradation behavior and mechanism of poly(ethylene glycol-co-1,4-cyclohexanedimethanol terephthalate) (PETG) random copolymers: correlation with copolymer composition

RSC Advances ◽  
2016 ◽  
Vol 6 (104) ◽  
pp. 102778-102790 ◽  
Author(s):  
Tingting Chen ◽  
Jun Zhang ◽  
Hongjun You
Keyword(s):  
Ethylene Glycol ◽  
Random Copolymers ◽  
Copolymer Composition ◽  
Type I ◽  
Poly Ethylene Glycol ◽  
Crosslinking Degree ◽  
Norrish Type ◽  
Poly Ethylene

Norrish type I and II mechanisms occurred in PETG copolymers. The inherent photostability of PETG decreased with increasing CHDM content. The higher CHDM content resulted in the higher crosslinking degree.

Polyethyleneimine and Poly(ethylene glycol) Functionalized Oligoester Based Polycationic Particles

MRS Advances ◽  
2018 ◽  
Vol 3 (50) ◽  
pp. 3033-3040
Author(s):  
Magdalena Mazurek-Budzynska ◽  
Maria Balk ◽  
Marc Behl ◽  
Andreas Lendlein
Keyword(s):  
Zeta Potential ◽  
Ethylene Glycol ◽  
Diblock Copolymer ◽  
Triblock Copolymer ◽  
Diblock Copolymers ◽  
Copolymer Composition ◽  
Surface Charges ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Carrier Systems

ABSTRACTPolycationic particles based on a degradable oligoester core are interesting candidate materials for the transfection of polyanionic macromolecules like DNA, which would enable the degradation after delivery of condensed molecules. Good transfection efficiencies can be obtained when the size of the polyplex (containing both polycationic nanoparticles and polyanionic macromolecules) does not exceed 120 nm. Therefore, here we explored how size, but also dispersity, and surface charge of these carrier systems can be adjusted by variation of the block copolymer composition or the presence and ratio of a co-assembly agent. Polycationic particles were obtained based on an amphiphilic triblock copolymer from oligo[(ε-caprolactone)-co-glycolide] (CG) functionalized with polyethyleneimine (PEI) and diblock copolymer based on poly(ethylene glycol) (PEG) modified with CG. A second series of particles was created, in which the oligoester blocks contained only ε-caprolactone units, therefore the effect of the presence of glycolide units was also studied. In both series, the ratio between di- and triblock copolymers was systematically varied. Nano-sized particles ranging from 34.5 ± 0.2 nm to 97.9 ± 0.3 nm with controllable positive surface charges between 2.9 ± 0.2 mV and 18.1 ± 0.5 mV were obtained by self-assembly in PBS solution under intensive stirring. The incorporation of PEG-C diblock copolymers resulted in an increase of particle size, however no specific relation between composition, size, and polydispersity was observed. In case of PEG-CG diblock copolymers a rather systematic increase of the particles’ size with increasing content of diblock copolymer was shown. Furthermore, with a decrease of content of diblock copolymer in the particle structure zeta potential strongly increased. Additionally, the content of glycolide units in triblock copolymer increased the zeta potential of PEI-CG-PEI-based particles in comparison to PEI-C-PEI-based ones. Therefore, obtained particles could be used as potential target-oriented polycationic macromolecules for carrier systems.

Synthesis, Characterization and Crystallization of Poly(Ethylene Glycol)-b-Poly(ε-Caprolactone)

2010 ◽  
Vol 152-153 ◽  
pp. 1665-1668
Author(s):  
Lian Liu ◽  
Pei Wang ◽  
Chao Qu ◽  
Zhi Yong Wei ◽  
Min Qi
Keyword(s):  
Ethylene Glycol ◽  
Ring Opening ◽  
Relative Length ◽  
Copolymer Composition ◽  
Poly Ethylene Glycol ◽  
Crystallization Behaviors ◽  
Poly Ethylene ◽  
Xrd Patterns ◽  
High Yields ◽  
Dsc Curves

A family of poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-PCL) were synthesized in high yields by the ring-opening polymerization of monomethoxy-terminated poly(ethylene glycol) (mPEG) with ε-caprolactone in the presence of stannous octoate (Sn(Oct)2). Their crystallization behaviors were studied by DSC, XRD. The results illustrated that crystallization behaviors of the copolymers depended on the copolymer composition and the relative length of each block in copolymers. The melting peak of PCL block appeared gradually in the XRD patterns and DSC curves in copolymers, with increasing of the length of PCL blocks.

pH-Responsive Hyperbranched Copolymers from One-Pot RAFT Copolymerization of Propylacrylic Acid and Poly(ethylene glycol diacrylate)

2012 ◽  
Vol 77 ◽  
pp. 333-342 ◽  
Author(s):  
Hong Yun Tai ◽  
Craig L. Duvall ◽  
Patrick S. Stayton ◽  
Alan S. Hoffman ◽  
Wen Xin Wang
Keyword(s):  
Ethylene Glycol ◽  
Proton Nuclear Magnetic Resonance ◽  
Therapeutic Drug ◽  
Copolymer Composition ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
One Pot ◽  
Glycol Diacrylate ◽  
Monomer Feed ◽  
Poly Ethylene

pH-Responsive polymers have attracted much attention for biotechnology applications as carriers or matrix to facilitate intracellular or extracellular therapeutic drug delivery and release. In this paper, we report the development of new pH-responsive and hyperbranched copolymers with potential for such applications. These pH-responsive hyperbranched copolymers were synthesized via one pot reversible addition-fragmentation chain transfer (RAFT) copolymerization of propylacrylic acid (PAA) and a branching co-monomer poly(ethylene glycol diacrylate) (PEGDA) (Mn=258 Da) at the monomer feed molar ratios [PAA]0/[PEGDA]0 = 99/1, 90/10 and 80/20. The resultant poly(PAA-PEGDA) copolymers were characterized by Proton Nuclear Magnetic Resonance (1H NMR) and Gel Permeation Chromatography (GPC) to obtain the molecular weight, copolymer composition and degree of acrylate functionality. The hydrodynamic dimensions of these copolymers at pH range between 5.0 and 7.4 were studied using Dynamic Light Scattering technique (DLS). Moreover, these hyperbranched copolymers demonstrated composition- and size-dependent membrane disruptive properties by red blood cell hemolysis assay. Poly(PAA-PEGDA) with the copolymer composition [PAA]/[PEGDA]= 68/32, obtained from the copolymerization at the monomer feed molar ratio [PAA]0/[PEGDA]0 = 99/1, demonstrated significant membrane disruptive activity.

Poly(ethylene glycol-co-1,4-cyclohexanedimethanol terephthalate) random copolymers: effect of copolymer composition and microstructure on the thermal properties and crystallization behavior

RSC Advances ◽  
2015 ◽  
Vol 5 (74) ◽  
pp. 60570-60580 ◽  
Author(s):  
Tingting Chen ◽  
Guodong Jiang ◽  
Guoyu Li ◽  
Zhipeng Wu ◽  
Jun Zhang
Keyword(s):  
Glass Transition ◽  
Thermal Properties ◽  
Crystallization Behavior ◽  
Random Copolymers ◽  
Sequence Length ◽  
Copolymer Composition ◽  
Poly Ethylene Glycol ◽  
Average Sequence Length ◽  
Average Sequence ◽  
Poly Ethylene

The glass transition temperature of the statistically random PETG copolymers increased linearly with the increasing CT content. An increase in the average sequence length resulted in a higher melting temperature.

scholarly journals Amphiphilic/fluorous random copolymers as a new class of non-cytotoxic polymeric materials for protein conjugation

2015 ◽  
Vol 6 (2) ◽  
pp. 240-247 ◽  
Author(s):  
Yuta Koda ◽  
Takaya Terashima ◽  
Mitsuo Sawamoto ◽  
Heather D. Maynard
Keyword(s):  
Ethylene Glycol ◽  
Polymeric Materials ◽  
Random Copolymers ◽  
Protein Conjugation ◽  
Poly Ethylene Glycol ◽  
New Class ◽  
Poly Ethylene

Amphiphilic/fluorous random copolymers bearing poly(ethylene glycol) chains and perfluorinated alkane pendants were developed as novel non-cytotoxic polymeric materials for protein conjugation.

“Functional Poly(ethylene glycol)”: PEG-Based Random Copolymers with 1,2-Diol Side Chains and Terminal Amino Functionality

2010 ◽  
Vol 43 (20) ◽  
pp. 8511-8518 ◽  
Author(s):  
Christine Mangold ◽  
Frederik Wurm ◽  
Boris Obermeier ◽  
Holger Frey
Keyword(s):  
Ethylene Glycol ◽  
Random Copolymers ◽  
Side Chains ◽  
Poly Ethylene Glycol ◽  
Terminal Amino ◽  
Poly Ethylene
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