Polyethyleneimine and Poly(ethylene glycol) Functionalized Oligoester Based Polycationic Particles

MRS Advances ◽  
2018 ◽  
Vol 3 (50) ◽  
pp. 3033-3040
Author(s):  
Magdalena Mazurek-Budzynska ◽  
Maria Balk ◽  
Marc Behl ◽  
Andreas Lendlein
Keyword(s):  
Zeta Potential ◽  
Ethylene Glycol ◽  
Diblock Copolymer ◽  
Triblock Copolymer ◽  
Diblock Copolymers ◽  
Copolymer Composition ◽  
Surface Charges ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Carrier Systems

ABSTRACTPolycationic particles based on a degradable oligoester core are interesting candidate materials for the transfection of polyanionic macromolecules like DNA, which would enable the degradation after delivery of condensed molecules. Good transfection efficiencies can be obtained when the size of the polyplex (containing both polycationic nanoparticles and polyanionic macromolecules) does not exceed 120 nm. Therefore, here we explored how size, but also dispersity, and surface charge of these carrier systems can be adjusted by variation of the block copolymer composition or the presence and ratio of a co-assembly agent. Polycationic particles were obtained based on an amphiphilic triblock copolymer from oligo[(ε-caprolactone)-co-glycolide] (CG) functionalized with polyethyleneimine (PEI) and diblock copolymer based on poly(ethylene glycol) (PEG) modified with CG. A second series of particles was created, in which the oligoester blocks contained only ε-caprolactone units, therefore the effect of the presence of glycolide units was also studied. In both series, the ratio between di- and triblock copolymers was systematically varied. Nano-sized particles ranging from 34.5 ± 0.2 nm to 97.9 ± 0.3 nm with controllable positive surface charges between 2.9 ± 0.2 mV and 18.1 ± 0.5 mV were obtained by self-assembly in PBS solution under intensive stirring. The incorporation of PEG-C diblock copolymers resulted in an increase of particle size, however no specific relation between composition, size, and polydispersity was observed. In case of PEG-CG diblock copolymers a rather systematic increase of the particles’ size with increasing content of diblock copolymer was shown. Furthermore, with a decrease of content of diblock copolymer in the particle structure zeta potential strongly increased. Additionally, the content of glycolide units in triblock copolymer increased the zeta potential of PEI-CG-PEI-based particles in comparison to PEI-C-PEI-based ones. Therefore, obtained particles could be used as potential target-oriented polycationic macromolecules for carrier systems.

Preparation and Drug Release Studies of Chitosan/Methoxy Poly(Ethylene Glycol)-b-Poly(D,L-Lactide-co-Glycolide) Nanocomposite Films for Use as Controlled Release Drug Delivery

2008 ◽  
Vol 55-57 ◽  
pp. 717-720 ◽  
Author(s):  
N. Niamsa ◽  
M. Srisa-ard ◽  
Y. Srisuwan ◽  
N. Kotsaeng ◽  
Y. Baimark ◽  
...  
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Diblock Copolymer ◽  
Diblock Copolymers ◽  
Chitosan Film ◽  
Water Soluble ◽  
Nanocomposite Films ◽  
Poly Ethylene Glycol ◽  
Chitosan Films ◽  
Poly Ethylene

Nanocomposite chitosan-based films incorporated with drug-loaded methoxy poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) diblock copolymers (MPEG-b-PDLLG) nanoparticles were prepared by forming drug-loaded nanoparticles in chitosan solution before suspension-solution film casting. Salicylic acid was used as a poorly-water soluble model drug. The nanocomposite films with DLL/G ratios of 100/0 and 85/15 mol% and chitosan/diblock copolymer/drug ratios of 80/1/1, 80/2/2 and 80/4/4 (w/w) were prepared and investigated. The sizes of drug-loaded nanoparticles into the chitosan films were approximate or less than 100 nm. Nanopores were observed in the resulted chitosan films incorporated with drug-loaded nanoparticles when the diblock copolymer ratio was increased up to 2. Number and size of the nanopores increased as increasing the diblock copolymer ratio. Only the nanocomposite films with chitosan/diblock copolymer/drug ratio of 80/1/1 (w/w) showed slower drug release than the chitosan film.

Synthesis and Characterization of a Novel Triblock Copolymer Containing Double-hydrophilic Blocks and Poly(fluoroalkyl methacrylate) Block via Oxyanioninitiated Polymerization

e-Polymers ◽  
2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Jie Xu ◽  
Peihong Ni ◽  
Jiang Mao
Keyword(s):  
Ethylene Glycol ◽  
Diblock Copolymer ◽  
Triblock Copolymer ◽  
Triblock Copolymers ◽  
Gel Permeation Chromatography ◽  
Monomethyl Ether ◽  
Critical Aggregation Concentration ◽  
Hydroxyl Group ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

AbstractA new triblock copolymer consisted of a double-hydrophilic diblock and a fluorinated block, namely poly(ethylene glycol)-b-poly[2-(dimethyl amino)-ethylmethacrylate]-b-poly(2,2,3,3,4,4,5,5-octafluoropentylmeth acrylate) (MePEG-b-PDMAEMA-b-POFPMA), was synthesized via oxyanioninitiated copolymerization. The hydroxyl group of poly(ethylene glycol) monomethyl ether (MePEG) reacted with potassium methylsulfinyl carbanion (DMSO-K+) and converted into a potassium alcoholate macroinitiator (MePEG-K). It could initiate DMAEMA monomer to yield a hydrophilichydrophilic diblock copolymer. If not quenched, the living chain could be subsequently used to initiate a second fed monomer such as OFPMA to produce a new triblock copolymer MePEG-b-PDMAEMA-b-POFPMA. As a comparison, the analogous triblock copolymers with different lengths of PDMAEMA and identical length of POFPMA were prepared. These copolymers were characterized by the measurements of 1H NMR, 19F NMR, and gel permeation chromatography (GPC). The results indicated that they had relatively low polydispersities (Mw/Mn̅ :1.25 −1.27) . The comparison of the critical aggregation concentration (CAC) of diblock copolymer MePEG-b- PDMAEMA and triblock copolymer MePEG-b-PDMAEMA-b-POFPMA has been investigated by measurements of surface tension and electrical conductivity. It was also found that the lower critical solution temperatures (LCSTs) of the di- and triblock copolymers varied with different factors, including the chemical structure, the length of DMAEMA block, and the concentration of the aqueous solution.

Reversibly cross-linked poly(ethylene glycol)–poly(amino acid)s copolymer micelles: a promising approach to overcome the extracellular stability versus intracellular drug release challenge

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 20025-20034 ◽  
Author(s):  
Yuling Li ◽  
Sai Wang ◽  
Dandan Zhu ◽  
Yuling Shen ◽  
Baixiang Du ◽  
...  
Keyword(s):  
Amino Acid ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Lipoic Acid ◽  
Triblock Copolymer ◽  
Intracellular Delivery ◽  
Poly Ethylene Glycol ◽  
Copolymer Micelles ◽  
Poly Ethylene ◽  
Copolymer Poly

Reversibly shell cross-linked micelles based on a lipoic acid (LA) decorated triblock copolymer poly(ethylene glycol)-b-poly(γ-benzyl-l-glutamate)-b-poly(l-phenylalanine) have been developed for efficient intracellular delivery of DOX.

FhuA deletion variant Δ1-159 overexpression in inclusion bodies and refolding with Polyethylene-Poly(ethylene glycol) diblock copolymer

2011 ◽  
Vol 77 (1) ◽  
pp. 75-79 ◽  
Author(s):  
Tamara Dworeck ◽  
Anne-Kathrin Petri ◽  
Noor Muhammad ◽  
Marco Fioroni ◽  
Ulrich Schwaneberg
Keyword(s):  
Ethylene Glycol ◽  
Diblock Copolymer ◽  
Inclusion Bodies ◽  
Poly Ethylene Glycol ◽  
Deletion Variant ◽  
Poly Ethylene

Preparation of thermo-responsive drug carrier consisting of biocompatible triblock copolymer and fullerene

2021 ◽  
Author(s):  
Kohei Kitano ◽  
Kazuhiko Ishihara ◽  
Shinichi Yusa
Keyword(s):  
Ethylene Glycol ◽  
Radical Polymerization ◽  
Triblock Copolymer ◽  
Drug Carrier ◽  
Controlled Radical Polymerization ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

A triblock copolymer (PEG-b-PUEM-b-PMPC; EUM) comprising poly(ethylene glycol) (PEG), thermo-responsive poly(2-ureidoethyl methacrylate) (PUEM), and poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC) blocks was synthesized via controlled radical polymerization. PEG and PMPC blocks exhibit hydrophilicity...

Microencapsulation of cytarabine using poly(ethylene glycol)–poly(ε-caprolactone) diblock copolymers as surfactant agents

2010 ◽  
Vol 36 (4) ◽  
pp. 456-469 ◽  
Author(s):  
Roudayna Diab ◽  
Misara Hamoudeh ◽  
Olivier Boyron ◽  
Abdelhamid Elaissari ◽  
Hatem Fessi
Keyword(s):  
Ethylene Glycol ◽  
Diblock Copolymers ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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