scholarly journals Amphiphilic/fluorous random copolymers as a new class of non-cytotoxic polymeric materials for protein conjugation

2015 ◽  
Vol 6 (2) ◽  
pp. 240-247 ◽  
Author(s):  
Yuta Koda ◽  
Takaya Terashima ◽  
Mitsuo Sawamoto ◽  
Heather D. Maynard

Amphiphilic/fluorous random copolymers bearing poly(ethylene glycol) chains and perfluorinated alkane pendants were developed as novel non-cytotoxic polymeric materials for protein conjugation.

1996 ◽  
Vol 29 (11) ◽  
pp. 3831-3838 ◽  
Author(s):  
Craig J. Hawker ◽  
Fengkui Chu ◽  
Peter J. Pomery ◽  
David J. T. Hill

2008 ◽  
Vol 1132 ◽  
Author(s):  
F. Bedoui ◽  
L. K. Widjaja ◽  
A. Luk ◽  
D. Bolikal ◽  
N. S. Murthy ◽  
...  

ABSTRACTIncrease in modulus upon hydration in copolymers of desaminotyrosyl-tyrosine ethyl ester (DTE) and poly(ethylene glycol) (PEG) with iodinated tyrosines, poly(I2DTE-co-PEG carbonate)s, was investigated by varying the fraction and the molecular weight of the hydrophilic PEG component. Water, as expected, acts as plasticizer in polymer with PEG content < 15 wt% and > 30 wt%. But, water has the opposite effect in iodinated polymers with moderate PEG contents, between 15 to 20 wt%: it enhances the Young's modulus. The strength and modulus of hydrated poly(I2DTE-co-15%PEG2K carbonate)s increased by as much as fifteen fold upon hydration. While the decrease in the mechanical properties in most polymeric materials with diluents such water is due to the solvent-induced swelling, the increase in strength and modulus that is observed is most likely due to the reinforcing effect of the increased cross-linking efficiency of the hydrated PEG domains in the iodinated polymer.


2020 ◽  
Vol 324 ◽  
pp. 228-237 ◽  
Author(s):  
Katia Maso ◽  
Antonella Grigoletto ◽  
Lucia Raccagni ◽  
Marino Bellini ◽  
Ilaria Marigo ◽  
...  

1994 ◽  
Vol 6 (12) ◽  
pp. 2208-2209 ◽  
Author(s):  
Glenn C. Rawsky ◽  
Tatsuo Fujinami ◽  
D. F. Shriver

2010 ◽  
Vol 43 (20) ◽  
pp. 8511-8518 ◽  
Author(s):  
Christine Mangold ◽  
Frederik Wurm ◽  
Boris Obermeier ◽  
Holger Frey

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