A nanoporous photosensitizing hydrogel based on chitosan cross-linked by zinc phthalocyanine: an injectable and pH-stimuli responsive system for effective cancer therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (94) ◽  
pp. 91445-91452 ◽  
Author(s):  
Ali Reza Karimi ◽  
Azam Khodadadi ◽  
Mahnaz Hadizadeh
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Therapeutic Efficacy ◽  
Zinc Phthalocyanine ◽  
Stimuli Responsive ◽  
Zinc Phthalocyanines ◽  
Tumor Selectivity ◽  
Biological Environment ◽  
Low Solubility ◽  
Effective Cancer Therapy

Although zinc phthalocyanines (ZnPcs) have promising applications in photodynamic therapy (PDT), their therapeutic efficacy suffer from their low solubility in the biological environment and their lack of tumor selectivity.

A Unique Self-Reporting Photosensitizer Enabling Simultaneous Photodynamic Therapy and Real-Time Monitoring Phototheranostic Process in a Dynamic Dual-Color Mode

2021 ◽  
Author(s):  
Dong-Hui Wang ◽  
Li-Jian Chen ◽  
Xu Zhao ◽  
Xiu-Ping Yan
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Real Time ◽  
Small Molecule ◽  
Therapeutic Efficacy ◽  
Real Time Monitoring ◽  
Dual Color

Phototheranostics has attracted great interest in cancer therapy. Small-molecule self-reporting photosensitizers, one kind of idea agents in phototheranostics, enable simultaneous photodynamic therapy (PDT) and feedback of therapeutic efficacy. However, previous...

3-Methylindole-substituted zinc phthalocyanines for photodynamic cancer therapy

2019 ◽  
Vol 23 (11n12) ◽  
pp. 1371-1379 ◽  
Author(s):  
Sami Ayari ◽  
Mehmet F. Saglam ◽  
Elif Şenkuytu ◽  
Pelin B. Erçin ◽  
Yunus Zorlu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Cancer Cell Line ◽  
Zinc Phthalocyanine ◽  
Quantum Yields ◽  
Light Conditions ◽  
Suitable Candidate ◽  
Zinc Phthalocyanines ◽  
Invasive Human Breast Cancer

Novel peripherally and non-peripherally 3-methylindole-substituted zinc phthalocyanine derivatives were synthesized as photosensitizers for photodynamic therapy in cancer treatment. The photophysical, photochemical and photobiological properties of targeted phthalocyanines were also investigated. For this purpose, the fluorescence and singlet oxygen quantum yields, and fluorescence lifetime values of the final compounds were determined in DMF solutions. The phototoxicity and cytotoxicity of the phthalocyanine complexes were tested against the invasive human breast cancer cell line (MDA-MB-231) for determination of their photosensitizing ability in the area of photodynamic therapy. It was revealed that while peripherally 3-methylindole-substituted phthalocyanine was found to be toxic for cells in both dark and light conditions, its non-peripherally substituted phthalocyanine analogue significantly caused cell death following light irradiation. A preliminary assay suggested that the non-peripherally linked phthalocyanine could be a suitable candidate for cancer treatment via photodynamic therapy techniques.

Acid-responsive H2-releasing Fe nanoparticles for safe and effective cancer therapy

2019 ◽  
Vol 7 (17) ◽  
pp. 2759-2765 ◽  
Author(s):  
Zhu Kou ◽  
Penghe Zhao ◽  
Zhihao Wang ◽  
Zhaokui Jin ◽  
Lihua Chen ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Hydrogen Molecules ◽  
Promising Strategy ◽  
Local Disease ◽  
Fe Nanoparticles ◽  
Disease Site ◽  
Low Solubility ◽  
Effective Cancer Therapy

Hydrogen therapy is an emerging and promising strategy for the treatment of inflammation-related diseases owing to the excellent bio-safety of hydrogen molecules (H2), but is facing a challenge that the H2 concentration at the local disease site is hardly accumulated because of its high diffusibility and low solubility, limiting the efficacy of hydrogen therapy.

pH/redox dual-stimuli-responsive cross-linked polyphosphazene nanoparticles for multimodal imaging-guided chemo-photodynamic therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (19) ◽  
pp. 9457-9467 ◽  
Author(s):  
Xunan Jing ◽  
Zhe Zhi ◽  
Liming Jin ◽  
Fei Wang ◽  
Youshen Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Multimodal Imaging ◽  
Great Promise ◽  
Stimuli Responsive

Multifunctional nanodrugs with the integration of precise diagnostic and effective therapeutic functions have shown great promise in improving the efficacy of cancer therapy.

Phthalocyanine-based coordination polymer nanoparticles for enhanced photodynamic therapy

Nanoscale ◽  
2017 ◽  
Vol 9 (41) ◽  
pp. 15883-15894 ◽  
Author(s):  
Ziyuan Huang ◽  
Liangfeng Huang ◽  
Yanjuan Huang ◽  
Yuanfeng He ◽  
Xiaoqi Sun ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Coordination Polymer ◽  
Singlet Oxygen ◽  
Polymer Nanoparticles ◽  
Zinc Phthalocyanine ◽  
Oxygen Yield ◽  
Low Solubility

The constructed nanoparticles solved the aggregation, low solubility and poor selectivity of zinc phthalocyanine along with high singlet oxygen yield.

A monomeric photosensitizer for targeted cancer therapy

2014 ◽  
Vol 50 (95) ◽  
pp. 14983-14986 ◽  
Author(s):  
Ruizheng Liang ◽  
Lina Ma ◽  
Lele Zhang ◽  
Chunyang Li ◽  
Wendi Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
Cancer Therapy ◽  
Zinc Phthalocyanine ◽  
Targeted Cancer Therapy

A targeted photosensitizer used in photodynamic therapy (PDT) was fabricated by incorporation of zinc phthalocyanine (ZnPc) and folic acid (FA) into polyvinylpyrrolidone (PVP) micelles, which exhibits excellent anticancer performance revealed by both in vitro studies and in vivo tests.

Photodynamic therapy-mediated remote control of chemotherapy toward synergistic anticancer treatment

Nanoscale ◽  
2018 ◽  
Vol 10 (30) ◽  
pp. 14554-14562 ◽  
Author(s):  
Yongjuan Li ◽  
Shixian Lv ◽  
Ziyuan Song ◽  
Juanjuan Dang ◽  
Xudong Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Remote Control ◽  
Cancer Therapy ◽  
Drug Release ◽  
Stimuli Responsive ◽  
On Demand ◽  
Release Property ◽  
Anticancer Treatment

Stimuli-responsive nanomedicine (NM) with an on-demand drug release property has demonstrated promising utility toward cancer therapy.

scholarly journals Photodynamic Therapy with Zinc Phthalocyanine Inhibits the Stemness and Development of Colorectal Cancer: Time to Overcome the Challenging Barriers?

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6877
Author(s):  
Mahsa Gholizadeh ◽  
Mohammad Amin Doustvandi ◽  
Fateme Mohammadnejad ◽  
Mahdi Abdoli Shadbad ◽  
Habib Tajalli ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Therapy Resistance ◽  
Zinc Phthalocyanine ◽  
Apoptosis Pathway ◽  
Intrinsic Apoptosis Pathway ◽  
Sw480 Cells ◽  
Tumoral Cells

Photodynamic therapy (PDT) is a light-based cancer therapy approach that has shown promising results in treating various malignancies. Growing evidence indicates that cancer stem cells (CSCs) are implicated in tumor recurrence, metastasis, and cancer therapy resistance in colorectal cancer (CRC); thus, targeting these cells can ameliorate the prognosis of affected patients. Based on our bioinformatics results, SOX2 overexpression is significantly associated with inferior disease-specific survival and worsened the progression-free interval of CRC patients. Our results demonstrate that zinc phthalocyanine (ZnPc)-PDT with 12 J/cm2 or 24 J/cm2 irradiation can substantially decrease tumor migration via downregulating MMP9 and ROCK1 and inhibit the clonogenicity of SW480 cells via downregulating CD44 and SOX2. Despite inhibiting clonogenicity, ZnPc-PDT with 12 J/cm2 irradiation fails to downregulate CD44 expression in SW480 cells. Our results indicate that ZnPc-PDT with 12 J/cm2 or 24 J/cm2 irradiation can substantially reduce the cell viability of SW480 cells and stimulate autophagy in the tumoral cells. Moreover, our results show that ZnPc-PDT with 12 J/cm2 or 24 J/cm2 irradiation can substantially arrest the cell cycle at the sub-G1 level, stimulate the intrinsic apoptosis pathway via upregulating caspase-3 and caspase-9 and downregulating Bcl-2. Indeed, our bioinformatics results show considerable interactions between the studied CSC-related genes with the studied migration- and apoptosis-related genes. Collectively, the current study highlights the potential role of ZnPc-PDT in inhibiting stemness and CRC development, which can ameliorate the prognosis of CRC patients.

scholarly journals Biomimetic Nanocarriers for Cancer Target Therapy

2020 ◽  
Vol 7 (3) ◽  
pp. 111 ◽  
Author(s):  
Clara Guido ◽  
Gabriele Maiorano ◽  
Barbara Cortese ◽  
Stefania D’Amone ◽  
Ilaria Elena Palamà
Keyword(s):  
Immune System ◽  
Cancer Therapy ◽  
Therapeutic Efficacy ◽  
Biomedical Application ◽  
Target Therapy ◽  
Targeted Cancer Therapy ◽  
Stimuli Responsive ◽  
New Strategy ◽  
Cell Sources

Nanotechnology offers innovative tools for the design of biomimetic nanocarriers for targeted cancer therapy. These nano-systems present several advantages such as cargo’s protection and modulation of its release, inclusion of stimuli-responsive elements, and enhanced tumoral accumulation. All together, these nano-systems suffer low therapeutic efficacy in vivo because organisms can recognize and remove foreign nanomaterials. To overcome this important issue, different modifications on nanoparticle surfaces were exploited in order to reach the desired therapeutic efficacy eliciting, also, the response of immune system against cancer cells. For this reason, more recently, a new strategy involving cell membrane-covered nanoparticles for biomedical application has been attracting increasing attention. Membranes from red blood cells, platelets, leukocytes, tumor, and stem cells, have been exploited as biomimetic coatings of nanoparticles for evading clearance or stimulated immune system by maintaining in the same way their targeting capability. In this review, the use of different cell sources as coating of biomimetic nanocarriers for cancer therapy is discussed.

Multi-stimuli responsive polymeric prodrug micelles for combined chemotherapy and photodynamic therapy

2020 ◽  
Vol 8 (24) ◽  
pp. 5267-5279 ◽  
Author(s):  
Cheng Hu ◽  
Weihua Zhuang ◽  
Tao Yu ◽  
Liang Chen ◽  
Zhen Liang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Combined Chemotherapy ◽  
Stimuli Responsive ◽  
Polymeric Prodrug ◽  
Stimuli Response

The strategy of novel multi-stimuli response and synergistic chemo–photodynamic therapy nanoplatform will be helpful for exploiting intelligent cancer therapy.

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