Phthalocyanine-based coordination polymer nanoparticles for enhanced photodynamic therapy

Nanoscale ◽  
2017 ◽  
Vol 9 (41) ◽  
pp. 15883-15894 ◽  
Author(s):  
Ziyuan Huang ◽  
Liangfeng Huang ◽  
Yanjuan Huang ◽  
Yuanfeng He ◽  
Xiaoqi Sun ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Coordination Polymer ◽  
Singlet Oxygen ◽  
Polymer Nanoparticles ◽  
Zinc Phthalocyanine ◽  
Oxygen Yield ◽  
Low Solubility

The constructed nanoparticles solved the aggregation, low solubility and poor selectivity of zinc phthalocyanine along with high singlet oxygen yield.

Cubic POSS engineering of photosensitizer-doped semiconducting polymer nanoparticles for enhanced fluorescence imaging and amplified photodynamic therapy

2020 ◽  
Vol 11 (44) ◽  
pp. 7035-7041
Author(s):  
Biqing Bao ◽  
Xue Zhai ◽  
Tianqi Liu ◽  
Peng Su ◽  
Luyao Zhou ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Fluorescence Imaging ◽  
Polymer Nanoparticles ◽  
Enhanced Fluorescence ◽  
Semiconducting Polymer ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Semiconducting Polymer Nanoparticles

PorPOSSC12 -doped semiconducting polymer nanoparticles with simultaneously enhanced fluorescence brightness and amplified singlet oxygen generation ability were designed for imaging-guided photodynamic therapy.

A nanoporous photosensitizing hydrogel based on chitosan cross-linked by zinc phthalocyanine: an injectable and pH-stimuli responsive system for effective cancer therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (94) ◽  
pp. 91445-91452 ◽  
Author(s):  
Ali Reza Karimi ◽  
Azam Khodadadi ◽  
Mahnaz Hadizadeh
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Therapeutic Efficacy ◽  
Zinc Phthalocyanine ◽  
Stimuli Responsive ◽  
Zinc Phthalocyanines ◽  
Tumor Selectivity ◽  
Biological Environment ◽  
Low Solubility ◽  
Effective Cancer Therapy

Although zinc phthalocyanines (ZnPcs) have promising applications in photodynamic therapy (PDT), their therapeutic efficacy suffer from their low solubility in the biological environment and their lack of tumor selectivity.

Synthesis and investigation of photophysicochemical properties of novel ketone-substituted gallium (III) and indium (III) phthalocyanines with high singlet oxygen yield for photodynamic therapy

2017 ◽  
Vol 192 ◽  
pp. 888-892 ◽  
Author(s):  
Armağan Günsel ◽  
Emre Güzel ◽  
Ahmet T. Bilgiçli ◽  
Göknur Yaşa Atmaca ◽  
Ali Erdoğmuş ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Oxygen Yield

The synthesis of new potential photosensitizers [1–3]. Part 4. Photophysical properties of some monophenyltripyridyl-porphyrin derivatives

2015 ◽  
Vol 19 (11) ◽  
pp. 1204-1211
Author(s):  
Piotr Kuś ◽  
Anna Pasewicz-Sokół ◽  
Alicja Ratuszna ◽  
Marcin Rojkiewicz
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Photophysical Properties ◽  
Anticancer Therapy ◽  
Fluorescence Yield ◽  
Potential Usefulness ◽  
Photodynamic Diagnosis ◽  
Porphyrin Derivatives ◽  
Oxygen Yield

Six monophenyltripyridylporphyrin derivatives were synthesized and characterized by spectroscopy in order to demonstrate their potential usefulness as photosensitizers for anticancer therapy purposes. Compounds 1 and 3–5 are amphiphilic, thus they may be suitable for transfer inside cells. Photochemical parameters such as fluorescence yield and singlet oxygen yield were determined. The former parameter does not exceed 10% which makes them unsuitable for photodynamic diagnosis (PDD). However, singlet oxygen yields are high and sufficient for these compounds to be considered as potential photodynamic therapy (PDT) photosensitizers.

A gold–chitosan composite with low symmetry zinc phthalocyanine for enhanced singlet oxygen generation and improved photodynamic therapy activity

2018 ◽  
Vol 42 (12) ◽  
pp. 10214-10225 ◽  
Author(s):  
Edith Dube ◽  
David O. Oluwole ◽  
Earl Prinsloo ◽  
Tebello Nyokong
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Zinc Phthalocyanine ◽  
Cytotoxicity Activity ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Chitosan Composite ◽  
Low Symmetry

A gold–chitosan composite with low symmetry zinc phthalocyanine showed no dark cytotoxicity activity and improved photodynamic therapy compared to that of the phthalocyanine alone.

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

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