scholarly journals Biomimetic Nanocarriers for Cancer Target Therapy

2020 ◽  
Vol 7 (3) ◽  
pp. 111 ◽  
Author(s):  
Clara Guido ◽  
Gabriele Maiorano ◽  
Barbara Cortese ◽  
Stefania D’Amone ◽  
Ilaria Elena Palamà
Keyword(s):  
Immune System ◽  
Cancer Therapy ◽  
Therapeutic Efficacy ◽  
Biomedical Application ◽  
Target Therapy ◽  
Targeted Cancer Therapy ◽  
Stimuli Responsive ◽  
New Strategy ◽  
Cell Sources

Nanotechnology offers innovative tools for the design of biomimetic nanocarriers for targeted cancer therapy. These nano-systems present several advantages such as cargo’s protection and modulation of its release, inclusion of stimuli-responsive elements, and enhanced tumoral accumulation. All together, these nano-systems suffer low therapeutic efficacy in vivo because organisms can recognize and remove foreign nanomaterials. To overcome this important issue, different modifications on nanoparticle surfaces were exploited in order to reach the desired therapeutic efficacy eliciting, also, the response of immune system against cancer cells. For this reason, more recently, a new strategy involving cell membrane-covered nanoparticles for biomedical application has been attracting increasing attention. Membranes from red blood cells, platelets, leukocytes, tumor, and stem cells, have been exploited as biomimetic coatings of nanoparticles for evading clearance or stimulated immune system by maintaining in the same way their targeting capability. In this review, the use of different cell sources as coating of biomimetic nanocarriers for cancer therapy is discussed.

scholarly journals Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 71
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Agents ◽  
Metal Species ◽  
Stimuli Responsive ◽  
Combination Drug ◽  
Incidence And Mortality

With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

scholarly journals Stimuli Responsive Nitric Oxide-Based Nanomedicine for Synergistic Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1917
Author(s):  
Yijun Zhao ◽  
Xumei Ouyang ◽  
Yongjun Peng ◽  
Shaojun Peng
Keyword(s):  
Nitric Oxide ◽  
Side Effects ◽  
Cancer Therapy ◽  
Normal Tissue ◽  
Weak Acid ◽  
Medical Community ◽  
Stimuli Responsive ◽  
Specific Distribution ◽  
Promising Therapeutic Approach

Gas therapy has received widespread attention from the medical community as an emerging and promising therapeutic approach to cancer treatment. Among all gas molecules, nitric oxide (NO) was the first one to be applied in the biomedical field for its intriguing properties and unique anti-tumor mechanisms which have become a research hotspot in recent years. Despite the great progress of NO in cancer therapy, the non-specific distribution of NO in vivo and its side effects on normal tissue at high concentrations have impaired its clinical application. Therefore, it is important to develop facile NO-based nanomedicines to achieve the on-demand release of NO in tumor tissue while avoiding the leakage of NO in normal tissue, which could enhance therapeutic efficacy and reduce side effects at the same time. In recent years, numerous studies have reported the design and development of NO-based nanomedicines which were triggered by exogenous stimulus (light, ultrasound, X-ray) or tumor endogenous signals (glutathione, weak acid, glucose). In this review, we summarized the design principles and release behaviors of NO-based nanomedicines upon various stimuli and their applications in synergistic cancer therapy. We also discuss the anti-tumor mechanisms of NO-based nanomedicines in vivo for enhanced cancer therapy. Moreover, we discuss the existing challenges and further perspectives in this field in the aim of furthering its development.

scholarly journals Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer Therapy

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1286 ◽  
Author(s):  
Lee ◽  
Jung ◽  
Jo ◽  
Yang ◽  
Koh ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Laser Irradiation ◽  
Near Infrared ◽  
Photothermal Effect ◽  
Great Promise ◽  
Targeted Cancer Therapy ◽  
Potential Applications ◽  
Photothermal Property ◽  
Nir Laser

Abstract: Photothermal therapy (PTT) using a near-infrared (NIR) heptamethine cyanine fluorophore has emerged as an alternative strategy for targeted cancer therapy. NIR fluorophores showing a high molar extinction coefficient and low fluorescence quantum yield have considerable potential applications in photothermal cancer therapy. In this study, a bifunctional sorbitol–ZW800 conjugate was used as an advanced concept of photothermal therapeutic agents for in vivo cancer imaging and therapy owing to the high tumor targetability of the sorbitol moiety and excellent photothermal property of NIR heptamethine cyanine fluorophore. The sorbitol–ZW800 showed an excellent photothermal effect increased by 58.7 °C after NIR laser irradiation (1.1 W/cm2) for 5 min. The HT-29 tumors targeted by sorbitol–ZW800 showed a significant decrease in tumor volumes for 7 days after photothermal treatment. Therefore, combining the bifunctional sorbitol–ZW800 conjugate and NIR laser irradiation is an alternative way for targeted cancer therapy, and this approach holds great promise as a safe and highly efficient NIR photothermal agent for future clinical applications.

A nanoporous photosensitizing hydrogel based on chitosan cross-linked by zinc phthalocyanine: an injectable and pH-stimuli responsive system for effective cancer therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (94) ◽  
pp. 91445-91452 ◽  
Author(s):  
Ali Reza Karimi ◽  
Azam Khodadadi ◽  
Mahnaz Hadizadeh
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Therapeutic Efficacy ◽  
Zinc Phthalocyanine ◽  
Stimuli Responsive ◽  
Zinc Phthalocyanines ◽  
Tumor Selectivity ◽  
Biological Environment ◽  
Low Solubility ◽  
Effective Cancer Therapy

Although zinc phthalocyanines (ZnPcs) have promising applications in photodynamic therapy (PDT), their therapeutic efficacy suffer from their low solubility in the biological environment and their lack of tumor selectivity.

Protein corona in drug delivery for multimodal cancer therapy in vivo

Nanoscale ◽  
2018 ◽  
Vol 10 (5) ◽  
pp. 2461-2472 ◽  
Author(s):  
Eugenia Li Ling Yeo ◽  
Patricia Soo Ping Thong ◽  
Khee Chee Soo ◽  
James Chen Yong Kah
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Therapeutic Efficacy ◽  
Tumor Regression ◽  
Protein Corona ◽  
Mouse Serum ◽  
Complete Tumor Regression ◽  
Tumor Accumulation ◽  
Complete Tumor

Intravenous delivery of NR-MS-Ce6, wherein Ce6 was loaded on NRs using a protein corona formed from mouse serum, resulted in tumor accumulation and synergy between PTT and PDT, leading to enhanced therapeutic efficacy and complete tumor regression in 19 days.

In vivo visualization of endogenous miR-21 using hyaluronic acid-coated graphene oxide for targeted cancer therapy

Biomaterials ◽  
2017 ◽  
Vol 121 ◽  
pp. 144-154 ◽  
Author(s):  
Do Won Hwang ◽  
Han Young Kim ◽  
Fangyuan Li ◽  
Ji Yong Park ◽  
Dohyun Kim ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Targeted Cancer Therapy

A monomeric photosensitizer for targeted cancer therapy

2014 ◽  
Vol 50 (95) ◽  
pp. 14983-14986 ◽  
Author(s):  
Ruizheng Liang ◽  
Lina Ma ◽  
Lele Zhang ◽  
Chunyang Li ◽  
Wendi Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
Cancer Therapy ◽  
Zinc Phthalocyanine ◽  
Targeted Cancer Therapy

A targeted photosensitizer used in photodynamic therapy (PDT) was fabricated by incorporation of zinc phthalocyanine (ZnPc) and folic acid (FA) into polyvinylpyrrolidone (PVP) micelles, which exhibits excellent anticancer performance revealed by both in vitro studies and in vivo tests.

scholarly journals Nanobody Conjugates for Targeted Cancer Therapy and Imaging

2021 ◽  
Vol 20 ◽  
pp. 153303382110101
Author(s):  
Wei Kang ◽  
Chuanfeng Ding ◽  
Danni Zheng ◽  
Xiao Ma ◽  
Lun Yi ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Full Potential ◽  
Targeted Cancer Therapy ◽  
Large Size ◽  
Naturally Occurring ◽  
Recent Developments ◽  
Potential Applications ◽  
Conventional Antibody ◽  
Insight Into

Conventional antibody-based targeted cancer therapy is one of the most promising avenues of successful cancer treatment, with the potential to reduce toxic side effects to healthy cells surrounding tumor cells. However, the full potential of antibodies is severely limited due to their large size, low stability, slow clearance, and high immunogenicity. Alternatively, recently discovered nanobodies, which are the smallest naturally occurring antigen-binding format, have shown great potential for addressing these limitations. Bioconjugation of nanobodies to functional groups such as toxins, enzymes, radionucleotides, and fluorophores can improve the efficacy and potency of nanobodies, enhance their in vivo pharmacokinetics, and expand the range of potential applications. Herein, we review the superior characteristics of nanobodies in comparison to conventional antibodies and provide insight into recent developments in nanobody conjugates for targeted cancer therapy and imaging.

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