Acid-responsive H2-releasing Fe nanoparticles for safe and effective cancer therapy

2019 ◽  
Vol 7 (17) ◽  
pp. 2759-2765 ◽  
Author(s):  
Zhu Kou ◽  
Penghe Zhao ◽  
Zhihao Wang ◽  
Zhaokui Jin ◽  
Lihua Chen ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Hydrogen Molecules ◽  
Promising Strategy ◽  
Local Disease ◽  
Fe Nanoparticles ◽  
Disease Site ◽  
Low Solubility ◽  
Effective Cancer Therapy

Hydrogen therapy is an emerging and promising strategy for the treatment of inflammation-related diseases owing to the excellent bio-safety of hydrogen molecules (H2), but is facing a challenge that the H2 concentration at the local disease site is hardly accumulated because of its high diffusibility and low solubility, limiting the efficacy of hydrogen therapy.

A nanoporous photosensitizing hydrogel based on chitosan cross-linked by zinc phthalocyanine: an injectable and pH-stimuli responsive system for effective cancer therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (94) ◽  
pp. 91445-91452 ◽  
Author(s):  
Ali Reza Karimi ◽  
Azam Khodadadi ◽  
Mahnaz Hadizadeh
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Therapeutic Efficacy ◽  
Zinc Phthalocyanine ◽  
Stimuli Responsive ◽  
Zinc Phthalocyanines ◽  
Tumor Selectivity ◽  
Biological Environment ◽  
Low Solubility ◽  
Effective Cancer Therapy

Although zinc phthalocyanines (ZnPcs) have promising applications in photodynamic therapy (PDT), their therapeutic efficacy suffer from their low solubility in the biological environment and their lack of tumor selectivity.

scholarly journals EGFR-mutant NSCLC presenting with stroke and massive systemic embolization as the first manifestation: case report

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zheng Wang ◽  
Jiangyong Miao ◽  
Lina Wang ◽  
Ying Liu ◽  
Hui Ji ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Cancer Therapy ◽  
Acute Ischemic Stroke ◽  
Oral Anticoagulants ◽  
Initial Manifestation ◽  
Arterial Thromboembolism ◽  
Systemic Embolization ◽  
Effective Cancer Therapy

Abstract Background Presentation with massive systemic embolization as the initial manifestation of occult malignancy is infrequent. The standard management of cancer-related arterial thromboembolism has not yet been established. Case presentation We described a case of Trousseau’s syndrome resulting in acute ischemic stroke concomitant with multiple embolizations in the spleen and kidney during oral administration of dabigatran for pulmonary embolism preceding the diagnosis of a malignant tumor. A cancer-related hypercoagulable state was suspected because the patient was admitted to the neurology department due to acute ischemic stroke with three territory infarcts on diffusion-weighted imaging (DWI) in the absence of identifiable conventional risk factors and brain vessel narrowing. The patient was subsequently diagnosed with epidermal growth factor receptor (EGFR) mutation–positive non-small-cell lung cancer (NSCLC) (stage IV) with pleural metastasis. Administration of low-molecular-weight heparin followed by long-term dabigatran under effective cancer therapy comprising gefitinib and subsequent chemotherapy did not cause stroke relapse during the 1-year follow-up. Conclusions This case suggests that cancer-related hypercoagulability should be considered an important etiology for stroke patients who develop unexplained disseminated acute cerebral infarction without conventional stroke risk factors, especially concomitant with multiple organ embolization. Novel oral anticoagulants may be an alternative therapy for the long-term management of cancer-related arterial thromboembolism under effective cancer therapy.

scholarly journals Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation

2015 ◽  
Vol 128 (3) ◽  
pp. 1062-1067 ◽  
Author(s):  
Tianjiao Ji ◽  
Ying Zhao ◽  
Yanping Ding ◽  
Jing Wang ◽  
Ruifang Zhao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Fibroblast Activation ◽  
Cancer Associated Fibroblast ◽  
Effective Cancer Therapy

Conceptually Novel Black Phosphorus/Cellulose Hydrogels as Promising Photothermal Agents for Effective Cancer Therapy

2018 ◽  
Vol 7 (7) ◽  
pp. 1701510 ◽  
Author(s):  
Chenyang Xing ◽  
Shiyou Chen ◽  
Meng Qiu ◽  
Xin Liang ◽  
Quan Liu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Black Phosphorus ◽  
Effective Cancer Therapy

Hollow Polypyrrole Nanospindles for Highly Effective Cancer Therapy

ChemPlusChem ◽  
2018 ◽  
Vol 83 (12) ◽  
pp. 1127-1134 ◽  
Author(s):  
Yixin Chen ◽  
Siyuan Xiang ◽  
Lu Wang ◽  
Mingyue Wang ◽  
Congcong Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Highly Effective ◽  
Effective Cancer Therapy

Discovery of novel dual c-Met/HDAC inhibitors as a promising strategy for cancer therapy

2020 ◽  
Vol 101 ◽  
pp. 103970 ◽  
Author(s):  
Hao Hu ◽  
Fei Chen ◽  
Yuhong Dong ◽  
Yajing Liu ◽  
Ping Gong
Keyword(s):  
Cancer Therapy ◽  
Hdac Inhibitors ◽  
Promising Strategy

High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a Near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy

ACS Nano ◽  
2014 ◽  
Vol 8 (7) ◽  
pp. 6922-6933 ◽  
Author(s):  
Wenyan Yin ◽  
Liang Yan ◽  
Jie Yu ◽  
Gan Tian ◽  
Liangjun Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
High Throughput ◽  
Near Infrared ◽  
Single Layer ◽  
Mos2 Nanosheets ◽  
Effective Cancer Therapy

scholarly journals Corrigendum: Hollow Polypyrrole Nanospindles for Highly Effective Cancer Therapy

ChemPlusChem ◽  
2021 ◽  
Author(s):  
Yixin Chen ◽  
Siyuan Xiang ◽  
Lu Wang ◽  
Mingyue Wang ◽  
Congcong Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Highly Effective ◽  
Effective Cancer Therapy

scholarly journals Mono-arginine Cholesterol-based Small Lipid Nanoparticles as a Systemic siRNA Delivery Platform for Effective Cancer Therapy

Theranostics ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. 192-203 ◽  
Author(s):  
Jinju Lee ◽  
Phei Er Saw ◽  
Vipul Gujrati ◽  
Yonghyun Lee ◽  
Hyungjun Kim ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Sirna Delivery ◽  
Lipid Nanoparticles ◽  
Delivery Platform ◽  
Effective Cancer Therapy
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