Dextrin and poly(lactide)-based biocompatible and biodegradable nanogel for cancer targeted delivery of doxorubicin hydrochloride

2016 ◽  
Vol 7 (17) ◽  
pp. 2965-2975 ◽  
Author(s):  
Dipankar Das ◽  
Priyapratim Patra ◽  
Paulomi Ghosh ◽  
Arun Prabhu Rameshbabu ◽  
Santanu Dhara ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Doxorubicin Hydrochloride ◽  
Anticancer Drug Delivery

Herein, we report the development and application of a novel biocompatible, chemically crosslinked nanogel for use in anticancer drug delivery.

scholarly journals Functional Magnetic Core-Shell System-Based Iron Oxide Nanoparticle Coated with Biocompatible Copolymer for Anticancer Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 120 ◽  
Author(s):  
Thai Hoang Thi ◽  
Diem-Huong Nguyen Tran ◽  
Long Bach ◽  
Hieu Vu-Quang ◽  
Duy Nguyen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Superparamagnetic Iron Oxide ◽  
Proton Nuclear Magnetic Resonance ◽  
Iron Oxide Nanoparticle ◽  
Core Shell ◽  
Anticancer Drug Delivery ◽  
Shell System

Polymer coating has drawn increasing attention as a leading strategy to overcome the drawbacks of superparamagnetic iron oxide nanoparticles (SPIONs) in targeted delivery of anticancer drugs. In this study, SPIONs were modified with heparin-Poloxamer (HP) shell to form a SPION@HP core-shell system for anticancer drug delivery. The obtained formulation was characterized by techniques including transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), vibration sample magnetometer (VSM), proton nuclear magnetic resonance (1H-NMR), and powder X-ray diffraction (XRD). Results showed the successful attachment of HP shell on the surface of SPION core and the inability to cause considerable effects to the crystal structure and unique magnetic nature of SPION. The core-shell system maintains the morphological features of SPIONs and the desired size range. Notably, Doxorubicin (DOX), an anticancer drug, was effectively entrapped into the polymeric shell of SPION@HP, showing a loading efficiency of 66.9 ± 2.7% and controlled release up to 120 h without any initial burst effect. Additionally, MTT assay revealed that DOX-loaded SPION@HP exerted great anticancer effect against HeLa cells and could be safely used. These results pave the way for the application of SPION@HP as an effective targeted delivery system for cancer treatment.

Folic acid-modified laponite nanodisks for targeted anticancer drug delivery

2014 ◽  
Vol 2 (42) ◽  
pp. 7410-7418 ◽  
Author(s):  
Yilun Wu ◽  
Rui Guo ◽  
Shihui Wen ◽  
Mingwu Shen ◽  
Meifang Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Anticancer Drug Delivery

Folic acid-modified laponite nanodisks can be used as an efficient platform for targeted delivery of doxorubicin via a receptor-mediated pathway.

scholarly journals In VitroCharacterization of Pluronic F127 and D--Tocopheryl Polyethylene Glycol 1000 Succinate Mixed Micelles as Nanocarriers for Targeted Anticancer-Drug Delivery

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Adeel Masood Butt ◽  
Mohd Cairul Iqbal Mohd Amin ◽  
Haliza Katas ◽  
Narong Sarisuta ◽  
Wasu Witoonsaridsilp ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Mixed Micelles ◽  
Chemotherapeutic Agents ◽  
Pluronic F127 ◽  
Breast Adenocarcinoma ◽  
Anticancer Drug Delivery ◽  
Polyethylene Glycol 1000

Mixed micelles of Pluronic F127 andD-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) in different molar ratios (10 : 0, 7 : 3, 5 : 5, and 3 : 7) were prepared to characterize this system as nanocarriers for targeted delivery of chemotherapeutic agents. Their size, zeta potential, critical micelle concentration, drug loading content, entrapment efficiency, drug release, cytotoxicity, and stability in serum were evaluatedin vitroby using doxorubicin as the model anticancer drug. The micellar sizes ranged from 25 to 35 nm. The 7 : 3 and 5 : 5 micellar combinations had lower critical micelle concentrations ( M) than the 10 : 0 combination ( M). The entrapment efficiencies of the 7 : 3, 5 : 5, and 3 : 7 micellar combinations were 72%, 88%, and 69%, respectively. Doxorubicin release was greater at acidic tumour pH than at normal physiological pH. The doxorubicin-loaded mixed micelles showed greater percent inhibition and apoptosis activity in human breast adenocarcinoma (MCF-7) and acute monocytic leukaemia (THP-1) cell lines than free doxorubicin did. The mixed micelles were also stable against aggregation and precipitation in serum. These findings suggest that Pluronic F127-TPGS mixed micelles could be used as nanocarriers for targeted anticancer-drug delivery.

HER2-Mediated Anticancer Drug Delivery: Strategies to Prepare Targeting Ligands Highly Specific for the Receptor

2015 ◽  
Vol 22 (21) ◽  
pp. 2525-2538 ◽  
Author(s):  
Enrica Calce ◽  
Luca Monfregola ◽  
Michele Saviano ◽  
Stefania De Luca
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Delivery Strategies

Advances in Nanoparticles as Anticancer Drug Delivery Vector: Need of this Century

2020 ◽  
Vol 26 (15) ◽  
pp. 1637-1649 ◽  
Author(s):  
Imran Ali ◽  
Sofi D. Mukhtar ◽  
Heyam S. Ali ◽  
Marcus T. Scotti ◽  
Luciana Scotti
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Medical Science ◽  
Drug Carriers ◽  
Anticancer Drug Delivery ◽  
Ph Values ◽  
Delivery Vector ◽  
Future Challenges ◽  
Smart Drug ◽  
Smart Drug Delivery

Background: Nanotechnology has contributed a great deal to the field of medical science. Smart drugdelivery vectors, combined with stimuli-based characteristics, are becoming increasingly important. The use of external and internal stimulating factors can have enormous benefits and increase the targeting efficiency of nanotechnology platforms. The pH values of tumor vascular tissues are acidic in nature, allowing the improved targeting of anticancer drug payloads using drug-delivery vectors. Nanopolymers are smart drug-delivery vectors that have recently been developed and recommended for use by scientists because of their potential targeting capabilities, non-toxicity and biocompatibility, and make them ideal nanocarriers for personalized drug delivery. Method: The present review article provides an overview of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. Results: This article reviews the molecular basis for the use of NPs in medicine, including personalized medicine, personalized therapy, emerging vistas in anticancer therapy, nanopolymer targeting, passive and active targeting transports, pH-responsive drug carriers, biological barriers, computer-aided drug design, future challenges and perspectives, biodegradability and safety. Conclusions: This article will benefit academia, researchers, clinicians, and government authorities by providing a basis for further research advancements.

scholarly journals Biocompatible, surface functionalized mesoporous titania nanoparticles for intracellular imaging and anticancer drug delivery

2011 ◽  
Vol 47 (18) ◽  
pp. 5232 ◽  
Author(s):  
Kevin C.-W. Wu ◽  
Yusuke Yamauchi ◽  
Chen-Yu Hong ◽  
Ya-Huei Yang ◽  
Yung-He Liang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Titania Nanoparticles ◽  
Mesoporous Titania ◽  
Intracellular Imaging ◽  
Anticancer Drug Delivery
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