Folic acid-modified laponite nanodisks for targeted anticancer drug delivery

2014 ◽  
Vol 2 (42) ◽  
pp. 7410-7418 ◽  
Author(s):  
Yilun Wu ◽  
Rui Guo ◽  
Shihui Wen ◽  
Mingwu Shen ◽  
Meifang Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Anticancer Drug Delivery

Folic acid-modified laponite nanodisks can be used as an efficient platform for targeted delivery of doxorubicin via a receptor-mediated pathway.

scholarly journals Functional Magnetic Core-Shell System-Based Iron Oxide Nanoparticle Coated with Biocompatible Copolymer for Anticancer Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 120 ◽  
Author(s):  
Thai Hoang Thi ◽  
Diem-Huong Nguyen Tran ◽  
Long Bach ◽  
Hieu Vu-Quang ◽  
Duy Nguyen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Superparamagnetic Iron Oxide ◽  
Proton Nuclear Magnetic Resonance ◽  
Iron Oxide Nanoparticle ◽  
Core Shell ◽  
Anticancer Drug Delivery ◽  
Shell System

Polymer coating has drawn increasing attention as a leading strategy to overcome the drawbacks of superparamagnetic iron oxide nanoparticles (SPIONs) in targeted delivery of anticancer drugs. In this study, SPIONs were modified with heparin-Poloxamer (HP) shell to form a SPION@HP core-shell system for anticancer drug delivery. The obtained formulation was characterized by techniques including transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), vibration sample magnetometer (VSM), proton nuclear magnetic resonance (1H-NMR), and powder X-ray diffraction (XRD). Results showed the successful attachment of HP shell on the surface of SPION core and the inability to cause considerable effects to the crystal structure and unique magnetic nature of SPION. The core-shell system maintains the morphological features of SPIONs and the desired size range. Notably, Doxorubicin (DOX), an anticancer drug, was effectively entrapped into the polymeric shell of SPION@HP, showing a loading efficiency of 66.9 ± 2.7% and controlled release up to 120 h without any initial burst effect. Additionally, MTT assay revealed that DOX-loaded SPION@HP exerted great anticancer effect against HeLa cells and could be safely used. These results pave the way for the application of SPION@HP as an effective targeted delivery system for cancer treatment.

A targeted drug delivery system based on folic acid-functionalized upconversion luminescent nanoparticles

2017 ◽  
Vol 31 (9) ◽  
pp. 1247-1256 ◽  
Author(s):  
Xuhua Liang ◽  
Jun Fan ◽  
Yanyan Zhao ◽  
Min Cheng ◽  
Xuejun Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Targeted Delivery ◽  
Cell Imaging ◽  
Ostwald Ripening ◽  
Upconversion Luminescence ◽  
Mesoporous Structure ◽  
Anticancer Drug Delivery ◽  
Free Doxorubicin ◽  
Luminescent Nanoparticles

In this paper, multifunctional upconversion luminescent NaYF4:Yb,Er nanoparticles with excellent hollow mesoporous structure were first fabricated. The effects of various reaction conditions on the morphology and size of the as-prepared samples were investigated in detail and Ostwald ripening effect was adapted to explain the formation mechanism of the HMUCNPs. Then, folic acid, a well-known ligand for the selective targeting of drugs into tumor cells, was conjugated to the surface of the hollow mesoporous structured upconversion luminescent nanoparticles (HMUCNPs) via amide reaction for targeted delivery of anticancer drugs so as to enhance the therapeutic efficacy. The properties were extensively studied, which indicated the obtained samples showed a typical hollow mesoporous structure and excellent upconversion luminescence that were useful for cell imaging and drug delivery. Drug storage/release properties were demonstrated to be pH responsive, in which the drug release might be beneficial at the reduced pH in certain cancerous tissues for targeted release and controlled therapy at the pathological sites. Meanwhile, DOX-NaYF4:Yb,Er-FA HMUCNPs exhibited greater cytotoxicity than free doxorubicin hydrochloride because folic acid-conjugated HMUCNPs can be specifically taken up by FR-positive KB cells via a receptor-mediated endocytosis. Therefore, the folic acid-functionalized nanoparticles combining upconversion luminescent property and hollow mesoporous structure have potential for simultaneous targeted anticancer drug delivery and cell imaging.

A multifunctional polyethylenimine-based nanoplatform for targeted anticancer drug delivery to tumors in vivo

2017 ◽  
Vol 5 (8) ◽  
pp. 1542-1550 ◽  
Author(s):  
Benqing Zhou ◽  
Lingzhou Zhao ◽  
Mingwu Shen ◽  
Jinhua Zhao ◽  
Xiangyang Shi
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Polyethylene Glycol ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery

Polyethylenimine can be modified with folic acid through a polyethylene glycol spacer for targeted anticancer drug delivery to tumors.

Dextrin and poly(lactide)-based biocompatible and biodegradable nanogel for cancer targeted delivery of doxorubicin hydrochloride

2016 ◽  
Vol 7 (17) ◽  
pp. 2965-2975 ◽  
Author(s):  
Dipankar Das ◽  
Priyapratim Patra ◽  
Paulomi Ghosh ◽  
Arun Prabhu Rameshbabu ◽  
Santanu Dhara ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Doxorubicin Hydrochloride ◽  
Anticancer Drug Delivery

Herein, we report the development and application of a novel biocompatible, chemically crosslinked nanogel for use in anticancer drug delivery.

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