scholarly journals In VitroCharacterization of Pluronic F127 and D--Tocopheryl Polyethylene Glycol 1000 Succinate Mixed Micelles as Nanocarriers for Targeted Anticancer-Drug Delivery

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Adeel Masood Butt ◽  
Mohd Cairul Iqbal Mohd Amin ◽  
Haliza Katas ◽  
Narong Sarisuta ◽  
Wasu Witoonsaridsilp ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Mixed Micelles ◽  
Chemotherapeutic Agents ◽  
Pluronic F127 ◽  
Breast Adenocarcinoma ◽  
Anticancer Drug Delivery ◽  
Polyethylene Glycol 1000

Mixed micelles of Pluronic F127 andD-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) in different molar ratios (10 : 0, 7 : 3, 5 : 5, and 3 : 7) were prepared to characterize this system as nanocarriers for targeted delivery of chemotherapeutic agents. Their size, zeta potential, critical micelle concentration, drug loading content, entrapment efficiency, drug release, cytotoxicity, and stability in serum were evaluatedin vitroby using doxorubicin as the model anticancer drug. The micellar sizes ranged from 25 to 35 nm. The 7 : 3 and 5 : 5 micellar combinations had lower critical micelle concentrations ( M) than the 10 : 0 combination ( M). The entrapment efficiencies of the 7 : 3, 5 : 5, and 3 : 7 micellar combinations were 72%, 88%, and 69%, respectively. Doxorubicin release was greater at acidic tumour pH than at normal physiological pH. The doxorubicin-loaded mixed micelles showed greater percent inhibition and apoptosis activity in human breast adenocarcinoma (MCF-7) and acute monocytic leukaemia (THP-1) cell lines than free doxorubicin did. The mixed micelles were also stable against aggregation and precipitation in serum. These findings suggest that Pluronic F127-TPGS mixed micelles could be used as nanocarriers for targeted anticancer-drug delivery.

Influence of polyethylene glycol molecular weight on the anticancer drug delivery of pH‐sensitive polymeric micelle

2019 ◽  
Vol 136 (32) ◽  
pp. 47854 ◽  
Author(s):  
Xiaotian Shan ◽  
Jing Mao ◽  
Miaomiao Long ◽  
Kamel S. Ahmed ◽  
Changling Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Polyethylene Glycol ◽  
Anticancer Drug ◽  
Polymeric Micelle ◽  
Ph Sensitive ◽  
Anticancer Drug Delivery

scholarly journals Functional Magnetic Core-Shell System-Based Iron Oxide Nanoparticle Coated with Biocompatible Copolymer for Anticancer Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 120 ◽  
Author(s):  
Thai Hoang Thi ◽  
Diem-Huong Nguyen Tran ◽  
Long Bach ◽  
Hieu Vu-Quang ◽  
Duy Nguyen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Superparamagnetic Iron Oxide ◽  
Proton Nuclear Magnetic Resonance ◽  
Iron Oxide Nanoparticle ◽  
Core Shell ◽  
Anticancer Drug Delivery ◽  
Shell System

Polymer coating has drawn increasing attention as a leading strategy to overcome the drawbacks of superparamagnetic iron oxide nanoparticles (SPIONs) in targeted delivery of anticancer drugs. In this study, SPIONs were modified with heparin-Poloxamer (HP) shell to form a SPION@HP core-shell system for anticancer drug delivery. The obtained formulation was characterized by techniques including transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), vibration sample magnetometer (VSM), proton nuclear magnetic resonance (1H-NMR), and powder X-ray diffraction (XRD). Results showed the successful attachment of HP shell on the surface of SPION core and the inability to cause considerable effects to the crystal structure and unique magnetic nature of SPION. The core-shell system maintains the morphological features of SPIONs and the desired size range. Notably, Doxorubicin (DOX), an anticancer drug, was effectively entrapped into the polymeric shell of SPION@HP, showing a loading efficiency of 66.9 ± 2.7% and controlled release up to 120 h without any initial burst effect. Additionally, MTT assay revealed that DOX-loaded SPION@HP exerted great anticancer effect against HeLa cells and could be safely used. These results pave the way for the application of SPION@HP as an effective targeted delivery system for cancer treatment.

Methoxy polyethylene glycol–cholesterol modified soy lecithin liposomes for poorly water‐soluble anticancer drug delivery

2020 ◽  
Vol 138 (7) ◽  
pp. 49858
Author(s):  
Ngoc Thuy Trang Le ◽  
Dinh Tien Dung Nguyen ◽  
Ngoc Hoi Nguyen ◽  
Cuu Khoa Nguyen ◽  
Dai Hai Nguyen
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Anticancer Drug ◽  
Water Soluble ◽  
Soy Lecithin ◽  
Anticancer Drug Delivery ◽  
Poorly Water Soluble ◽  
Methoxy Polyethylene Glycol

Redox-sensitive mesoporous silica nanoparticles functionalized with PEG through a disulfide bond linker for potential anticancer drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (73) ◽  
pp. 59576-59582 ◽  
Author(s):  
Huameng Gong ◽  
Zhifei Xie ◽  
Mingxing Liu ◽  
Hongda Zhu ◽  
Honghao Sun
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drug ◽  
Disulfide Bond ◽  
Mesoporous Silica Nanoparticles ◽  
Thiol Group ◽  
Anticancer Drug Delivery ◽  
Methoxy Polyethylene Glycol

In this paper, redox-sensitive mesoporous silica nanoparticles (MSNs–SS–PEG) were successfully synthesized using silica nanoparticles modified with a thiol group (MSNs–SH) and thiol-functionalized methoxy polyethylene glycol (MeOPEG–SH).

A multifunctional polyethylenimine-based nanoplatform for targeted anticancer drug delivery to tumors in vivo

2017 ◽  
Vol 5 (8) ◽  
pp. 1542-1550 ◽  
Author(s):  
Benqing Zhou ◽  
Lingzhou Zhao ◽  
Mingwu Shen ◽  
Jinhua Zhao ◽  
Xiangyang Shi
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Polyethylene Glycol ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery

Polyethylenimine can be modified with folic acid through a polyethylene glycol spacer for targeted anticancer drug delivery to tumors.

Dextrin and poly(lactide)-based biocompatible and biodegradable nanogel for cancer targeted delivery of doxorubicin hydrochloride

2016 ◽  
Vol 7 (17) ◽  
pp. 2965-2975 ◽  
Author(s):  
Dipankar Das ◽  
Priyapratim Patra ◽  
Paulomi Ghosh ◽  
Arun Prabhu Rameshbabu ◽  
Santanu Dhara ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Doxorubicin Hydrochloride ◽  
Anticancer Drug Delivery

Herein, we report the development and application of a novel biocompatible, chemically crosslinked nanogel for use in anticancer drug delivery.

Folic acid-modified laponite nanodisks for targeted anticancer drug delivery

2014 ◽  
Vol 2 (42) ◽  
pp. 7410-7418 ◽  
Author(s):  
Yilun Wu ◽  
Rui Guo ◽  
Shihui Wen ◽  
Mingwu Shen ◽  
Meifang Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Anticancer Drug Delivery

Folic acid-modified laponite nanodisks can be used as an efficient platform for targeted delivery of doxorubicin via a receptor-mediated pathway.

Redox-Sensitive Core Cross-Linked Polyethylene Glycol-Polypeptide Hybrid Micelles for Anticancer Drug Delivery

2017 ◽  
Vol 17 (7) ◽  
pp. 4532-4541 ◽  
Author(s):  
Lidong Li ◽  
Le Shang ◽  
Kanglong Chen ◽  
Qiuyue Wang ◽  
Jianbin Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery

scholarly journals Pluronic F127 self-assembled MoS2 nanocomposites as an effective glutathione responsive anticancer drug delivery system

RSC Advances ◽  
2019 ◽  
Vol 9 (44) ◽  
pp. 25592-25601 ◽  
Author(s):  
Adhisankar Vadivelmurugan ◽  
Rajeshkumar Anbazhagan ◽  
Vinothini Arunagiri ◽  
Juin-Yih Lai ◽  
Hsieh-Chih Tsai
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Drug Carrier ◽  
Pluronic F127 ◽  
Anticancer Drug Delivery ◽  
System P ◽  
Self Assembled

In this study, bio-responsive polymeric MoS2 nanocomposites were prepared for use as a drug carrier for cancer therapy.

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