Enzyme and pH-responsive nanovehicles for intracellular drug release and photodynamic therapy

2017 ◽  
Vol 41 (6) ◽  
pp. 2468-2478 ◽  
Author(s):  
Ting Zhang ◽  
Shiying Huang ◽  
Huiming Lin ◽  
Na An ◽  
Ruihan Tong ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Drug Release ◽  
Cancer Treatment ◽  
Potential Application ◽  
The Novel ◽  
Ph Responsive

An enzyme and pH-responsive nanocomposite was constructed for sensitive intracellular drug release and photodynamic therapy (PDT). The novel nanoplatforms provide the potential application in cancer treatment.

scholarly journals Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment

Nano Research ◽  
2019 ◽  
Vol 12 (5) ◽  
pp. 999-1008 ◽  
Author(s):  
Yongjuan Li ◽  
Jian Hu ◽  
Xun Liu ◽  
Yong Liu ◽  
Shixian Lv ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Drug Release ◽  
Cancer Treatment ◽  
On Demand ◽  
Anti Cancer

scholarly journals Multifunctional nanoplatforms as cascade-responsive drug-delivery carriers for effective synergistic chemo-photodynamic cancer treatment

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Fan Li ◽  
Yan Liang ◽  
Miaochen Wang ◽  
Xing Xu ◽  
Fen Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Blood Circulation ◽  
The Novel ◽  
Hydrophobic Core ◽  
Cancer Suppression ◽  
532 Nm

AbstractSynergistic chemo-photodynamic therapy has garnered attention in the field of cancer treatment. Here, a pH cascade-responsive micellar nanoplatform with nucleus-targeted ability, for effective synergistic chemo-photodynamic cancer treatment, was fabricated. In this micellar nanoplatform, 5-(4-carboxyphenyl)-10,15,20-triphenylporphyrin (Por), a photodynamic therapy (PDT) agent was utilized for carrying the novel anticancer drug GNA002 to construct a hydrophobic core, and cyclic RGD peptide (cRGD)-modified polyethylene glycol (PEG) (cRGD-PEG) connected the cell-penetrating peptide hexaarginine (R6) through a pH-responsive hydrazone bond (cRGD-PEG-N = CH-R6) to serve as a hydrophilic shell for increasing blood circulation time. After passively accumulating in tumor sites, the self-assembled GNA002-loaded nanoparticles were actively internalized into cancer cells via the cRGD ligands. Once phagocytosed by lysosomes, the acidity-triggered detachment of the cRGD-PEG shell led to the formation of R6-coated secondary nanoparticles and subsequent R6-mediated nucleus-targeted drug delivery. Combined with GNA002-induced nucleus-specific chemotherapy, reactive oxygen species produced by Por under 532-nm laser irradiation achieved a potent synergistic chemo-photodynamic cancer treatment. Moreover, our in vitro and in vivo anticancer investigations revealed high cancer-suppression efficacy of this ideal multifunctional nanoplatform, indicating that it could be a promising candidate for synergistic anticancer therapy.

scholarly journals Design and Characterisation of pH-Responsive Photosensitiser-Loaded Nano-Transfersomes for Enhanced Photodynamic Therapy

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 210
Author(s):  
Sooho Yeo ◽  
Il Yoon ◽  
Woo Kyoung Lee
Keyword(s):  
Photodynamic Therapy ◽  
Drug Release ◽  
Burst Release ◽  
Ph Responsive ◽  
Pheophorbide A ◽  
Sustained Drug Release ◽  
Non Invasive ◽  
Anti Cancer ◽  
Photodynamic Activity ◽  
The Mean

Photodynamic therapy (PDT) is a non-invasive and tumour-specific therapy. Photosensitizers (PSs) (essential ingredients in PDT) aggregate easily owing to their lipophilic properties. The aim of this study was to synthesise a PS (methyl pheophorbide a, MPa) and design a biocompatible lipid-based nanocarrier to improve its bioavailability and pharmacological effects. MPa-loaded nano-transfersomes were fabricated by sonication. The characteristics of synthesised PS and nano-transfersomes were assessed. The effects of PDT were evaluated by 1,3-diphenylisobenzofuran assay and by measuring photo-cytotoxicity against HeLa and A549 cell lines. The mean particle size and zeta potential for nano-transfersomes ranged from 95.84 to 267.53 nm and −19.53 to −45.08 mV, respectively. Nano-transfersomes exhibited sustained drug release for 48 h in a physiological environment (as against burst release in an acidic environment), which enables its use as a pH-responsive drug release system in PDT with enhanced photodynamic activity and reduced side effects. The formulations showed light cytotoxicity, but no dark toxicity, which meant that light irradiation resulted in anti-cancer effects. Additionally, formulations with the smallest size exhibited photodynamic activity to a larger extent than those with the highest loading capacity or free MPa. These results suggest that our MPa-loaded nano-transfersome system is a promising anti-cancer strategy for PDT.

pH-Responsive drug release and NIR-triggered singlet oxygen generation based on a multifunctional core–shell–shell structure

2016 ◽  
Vol 18 (36) ◽  
pp. 25497-25503 ◽  
Author(s):  
Renlu Han ◽  
Haopeng Yi ◽  
Junhui Shi ◽  
Zongjun Liu ◽  
Hao Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Shell Structure ◽  
Near Infrared ◽  
Core Shell ◽  
The Novel ◽  
Ph Responsive ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light ◽  
Multifunctional Platform

A multifunctional platform drug with pH-responsive drug release and near-infrared (NIR) light-triggered photodynamic therapy (PDT) was designed and prepared using the novel core–shell–shell structure.

A metal–phenolic network-based multifunctional nanocomposite with pH-responsive ROS generation and drug release for synergistic chemodynamic/photothermal/chemo-therapy

2020 ◽  
Vol 8 (10) ◽  
pp. 2177-2188 ◽  
Author(s):  
Xiangyu Meng ◽  
Lizhu Chen ◽  
Rongmu Lv ◽  
Mei Liu ◽  
Nongyue He ◽  
...  
Keyword(s):  
Drug Release ◽  
Combination Therapy ◽  
Cancer Treatment ◽  
Ros Generation ◽  
Ph Responsive ◽  
Promising Strategy ◽  
Multifunctional Nanomaterials

Developing multifunctional nanomaterials with chemodynamic therapy (CDT)-based combination therapy has increasingly become a promising strategy for cancer treatment.

scholarly journals DOX sensitized upconversion metal–organic frameworks for the pH responsive release and real-time detection of doxorubicin hydrochloride

RSC Advances ◽  
2020 ◽  
Vol 10 (56) ◽  
pp. 33894-33902
Author(s):  
Feng Tian ◽  
Chen Xu ◽  
Mingyue Xu ◽  
Haiqing Gao ◽  
Ziyi Xiao ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Drug Release ◽  
Cancer Treatment ◽  
Real Time ◽  
Metal Organic Frameworks ◽  
Major Obstacle ◽  
Doxorubicin Hydrochloride ◽  
Ph Responsive ◽  
Metal Organic ◽  
Real Time Detection

Drug resistance is a major obstacle in cancer treatment, and designing a material that monitors real-time drug release remains a top priority.

scholarly journals Multifunctional Nanoplatforms as Cascade-Responsive Drug-Delivery Carriers for Effective Synergistic Chemo-Photodynamic Cancer Treatment

2021 ◽  
Author(s):  
Fan Li ◽  
Yan Liang ◽  
Miaochen Wang ◽  
Xing Xu ◽  
Fen Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Blood Circulation ◽  
The Novel ◽  
Hydrophobic Core ◽  
Cancer Suppression ◽  
532 Nm

Abstract Synergistic chemo-photodynamic therapy has attracted increasing attention in the field of cancer treatment. Herein, a pH cascade-responsive micellar nanoplatform with nucleus-targeted ability was fabricated, which could implement effective synergistic chemo-photodynamic cancer treatment. In this micellar nanoplatform, 5-(4-carboxyphenyl)-10,15,20-triphenylporphyrin (Por), a photodynamic therapy (PDT) agent, was utilized to carry the novel anticancer drug GNA002 to construct a hydrophobic core, and cyclic RGD peptide (cRGD)-modified polyethylene glycol (PEG) (cRGD-PEG) connected the cell-penetrating peptide hexaarginine (R6) through a pH-responsive hydrazone bond (cRGD-PEG-N=CH-R6) to serve as a hydrophilic shell for increasing blood circulation time. After passively accumulating in tumor sites, the self-assembled GNA002-loaded nanoparticles were actively internalized into cancer cells via cRGD ligands. Once phagocytosed by lysosomes, the acidity-triggered detachment of the cRGD-PEG shell led to the formation of R6-coated secondary nanoparticles and subsequent R6-mediated nucleus-targeted drug delivery. Combined with GNA002-induced nucleus-specific chemotherapy, reactive oxygen species produced by Por under 532-nm laser irradiation achieved a potent synergistic chemo-photodynamic cancer treatment. Moreover, our in vitro and in vivo anticancer investigations proved this ideal multifunctional nanoplatform showed a high cancer-suppression efficacy and could be a promising candidate for synergistic anticancer therapy.

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

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