A metal–phenolic network-based multifunctional nanocomposite with pH-responsive ROS generation and drug release for synergistic chemodynamic/photothermal/chemo-therapy

2020 ◽  
Vol 8 (10) ◽  
pp. 2177-2188 ◽  
Author(s):  
Xiangyu Meng ◽  
Lizhu Chen ◽  
Rongmu Lv ◽  
Mei Liu ◽  
Nongyue He ◽  
...  
Keyword(s):  
Drug Release ◽  
Combination Therapy ◽  
Cancer Treatment ◽  
Ros Generation ◽  
Ph Responsive ◽  
Promising Strategy ◽  
Multifunctional Nanomaterials

Developing multifunctional nanomaterials with chemodynamic therapy (CDT)-based combination therapy has increasingly become a promising strategy for cancer treatment.

scholarly journals Multifunctional Cargo-Free Nanomedicine for Cancer Therapy

2018 ◽  
Vol 19 (10) ◽  
pp. 2963 ◽  
Author(s):  
Ying Wang ◽  
Pengfei Yang ◽  
Xinrui Zhao ◽  
Di Gao ◽  
Na Sun ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Cancer Therapy ◽  
Drug Release ◽  
Combination Therapy ◽  
Cancer Treatment ◽  
Clinical Applications ◽  
Self Monitoring ◽  
Promising Strategy ◽  
Carrier Free ◽  
Future Challenges

Nanocarriers encapsulating multiple chemotherapeutics are a promising strategy to achieve combinational chemotherapy for cancer therapy; however, they generally use exotic new carriers without therapeutic effect, which usually suffer from carrier-related toxicity issues, as well as having to pass extensive clinical trials to be drug excipients before any clinical applications. Cargo-free nanomedicines, which are fabricated by drugs themselves without new excipients and possess nanoscale characteristics to realize favorable pharmacokinetics and intracellular delivery, have been rapidly developed and drawn much attention to cancer treatment. Herein, we discuss recent advances of cargo-free nanomedicines for cancer treatment. After a brief introduction to the major types of carrier-free nanomedicine, some representative applications of these cargo-free nanomedicines are discussed, including combination therapy, immunotherapy, as well as self-monitoring of drug release. More importantly, this review draws a brief conclusion and discusses the future challenges of cargo-free nanomedicines from our perspective.

In situ injection of dual-delivery PEG based MMP-2 sensitive hydrogels for enhanced tumor penetration and chemo-immune combination therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jianqin Yan ◽  
Zhuangzhuang Zhang ◽  
xiaohui Zhan ◽  
Keqi Chen ◽  
Yuji Pu ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Cancer Treatment ◽  
Deep Penetration ◽  
Tumor Penetration ◽  
Dna Nanostructure ◽  
Promising Strategy

mproving the deep penetration of nanoparticles and realizing the combination of chemotherapy and immunotherapy have become a promising strategy for cancer treatment. Herein, nuclear-targeted tetrahedral DNA nanostructure (NLS-TDNs, NT) was...

scholarly journals Bovine serum albumin-loaded nano-selenium/ICG nanoparticles for highly effective chemo-photothermal combination therapy

RSC Advances ◽  
2017 ◽  
Vol 7 (49) ◽  
pp. 30717-30724 ◽  
Author(s):  
Guanjun Deng ◽  
Ting Zhu ◽  
Lihua Zhou ◽  
Jingnan Zhang ◽  
Sanpeng Li ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Combination Therapy ◽  
Serum Albumin ◽  
Cancer Treatment ◽  
Bovine Serum ◽  
Promising Strategy ◽  
Highly Effective

Chemo-photothermal combination therapy has already become a promising strategy for cancer treatment.

Enzyme and pH-responsive nanovehicles for intracellular drug release and photodynamic therapy

2017 ◽  
Vol 41 (6) ◽  
pp. 2468-2478 ◽  
Author(s):  
Ting Zhang ◽  
Shiying Huang ◽  
Huiming Lin ◽  
Na An ◽  
Ruihan Tong ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Drug Release ◽  
Cancer Treatment ◽  
Potential Application ◽  
The Novel ◽  
Ph Responsive

An enzyme and pH-responsive nanocomposite was constructed for sensitive intracellular drug release and photodynamic therapy (PDT). The novel nanoplatforms provide the potential application in cancer treatment.

Co-delivery of doxorubicin and methotrexate by dendritic chitosan-g-mPEG as a magnetic nanocarrier for multi-drug delivery in combination chemotherapy

2017 ◽  
Vol 8 (47) ◽  
pp. 7333-7350 ◽  
Author(s):  
Mahdi Rahimi ◽  
Kazem D. Safa ◽  
Roya Salehi
Keyword(s):  
Drug Delivery ◽  
Combination Therapy ◽  
Cancer Treatment ◽  
Combination Chemotherapy ◽  
Anticancer Agents ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Synergistic Effects ◽  
Delivery Systems ◽  
Promising Strategy

Nanoparticulate drug delivery systems have the potential to improve the therapeutic efficacy of anticancer agents, and combination therapy is a promising strategy for clinical cancer treatment with synergistic effects.

Gas-generating mesoporous silica nanoparticles with rapid localized drug release for enhanced chemophotothermal tumor therapy

2020 ◽  
Vol 8 (23) ◽  
pp. 6754-6763
Author(s):  
Zhiming Zhang ◽  
Li Zhang ◽  
Chenlu Huang ◽  
Qing Guo ◽  
Yueyue Zuo ◽  
...  
Keyword(s):  
Drug Release ◽  
Combination Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Tumor Therapy ◽  
Promising Strategy

Chemophotothermal combination therapy has emerged as a novel and promising strategy to treat cancer.

scholarly journals DOX sensitized upconversion metal–organic frameworks for the pH responsive release and real-time detection of doxorubicin hydrochloride

RSC Advances ◽  
2020 ◽  
Vol 10 (56) ◽  
pp. 33894-33902
Author(s):  
Feng Tian ◽  
Chen Xu ◽  
Mingyue Xu ◽  
Haiqing Gao ◽  
Ziyi Xiao ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Drug Release ◽  
Cancer Treatment ◽  
Real Time ◽  
Metal Organic Frameworks ◽  
Major Obstacle ◽  
Doxorubicin Hydrochloride ◽  
Ph Responsive ◽  
Metal Organic ◽  
Real Time Detection

Drug resistance is a major obstacle in cancer treatment, and designing a material that monitors real-time drug release remains a top priority.

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