pH-Responsive drug release and NIR-triggered singlet oxygen generation based on a multifunctional core–shell–shell structure

2016 ◽  
Vol 18 (36) ◽  
pp. 25497-25503 ◽  
Author(s):  
Renlu Han ◽  
Haopeng Yi ◽  
Junhui Shi ◽  
Zongjun Liu ◽  
Hao Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Shell Structure ◽  
Near Infrared ◽  
Core Shell ◽  
The Novel ◽  
Ph Responsive ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light ◽  
Multifunctional Platform

A multifunctional platform drug with pH-responsive drug release and near-infrared (NIR) light-triggered photodynamic therapy (PDT) was designed and prepared using the novel core–shell–shell structure.

Biodegradable Nano-photosensitizer with Photoactivatable Singlet Oxygen Generation for Synergistic Phototherapy

2021 ◽  
Author(s):  
Jiaxin Shen ◽  
Dandan Chen ◽  
Ye Liu ◽  
Guoyang Gao ◽  
Zhihe Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Promising Method ◽  
Normal Cells ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light

Photodynamic therapy (PDT) is a promising method for cancer therapy and also may initiate unexpected damages to normal cells and tissues. Herein, we developed a near-infrared (NIR) light-activatable nanophotosensitizer, which...

scholarly journals Core-shell structure microcapsules with dual pH-responsive drug release function

2014 ◽  
Vol 35 (18) ◽  
pp. NA-NA
Author(s):  
Chih-Hui Yang ◽  
Chih-Yu Wang ◽  
Alexandru Mihai Grumezescu ◽  
Andrew H.-J. Wang ◽  
Ching-Ju Hsiao ◽  
...  
Keyword(s):  
Drug Release ◽  
Shell Structure ◽  
Core Shell ◽  
Ph Responsive ◽  
Core Shell Structure

Core-shell structure microcapsules with dual pH-responsive drug release function

2014 ◽  
Vol 35 (18) ◽  
pp. 2673-2680 ◽  
Author(s):  
Chih-Hui Yang ◽  
Chih-Yu Wang ◽  
Alexandru Mihai Grumezescu ◽  
Andrew H.-J. Wang ◽  
Ching-Ju Hsiao ◽  
...  
Keyword(s):  
Drug Release ◽  
Shell Structure ◽  
Core Shell ◽  
Ph Responsive ◽  
Core Shell Structure

Singlet oxygen generation under NIR light and visible light excitations of photosensitizers on upconversion nanoparticle surface

RSC Advances ◽  
2015 ◽  
Vol 5 (83) ◽  
pp. 67892-67895 ◽  
Author(s):  
Padmanabh Joshi ◽  
Tevhide Ozkaya Ahmadov ◽  
Peng Wang ◽  
Peng Zhang
Keyword(s):  
Visible Light ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light ◽  
Nanoparticle Surface

Effects of beef tissue on singlet oxygen generation under both near-infrared and visible light excitations are investigated and compared.

scholarly journals Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Black Phosphorus ◽  
Deep Penetration ◽  
Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

scholarly journals NIR-Responsive Lysosomotropic Phototrigger: ʽAIE + ESIPTʼ Active Naphthalene Based Single Component Photoresponsive Nanocarrier with Two-Photon Uncaging and Real-Time Monitoring Ability

2021 ◽  
Author(s):  
Biswajit Roy ◽  
Rakesh Mengji ◽  
Samrat Roy ◽  
Bipul Pal ◽  
Avijit Jana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Real Time ◽  
Near Infrared ◽  
Single Component ◽  
Photon Absorption ◽  
Real Time Monitoring ◽  
Two Photon ◽  
Nir Light

In recent times, organelle-targeted drug delivery systems gained tremendous attention due to the site specific delivery of active drug molecules resulting in enhanced bioefficacy. In this context, the phototriggered drug delivery system (DDS) for releasing an active molecule is superior as it provides spatial and temporal control over the release. So far, near infrared (NIR) light responsive organelle targeted DDS has not yet been developed. Hence, we introduced a two-photon NIR-light responsive lysosome targeted ʽAIE + ESIPTʼ active single component DDS based on naphthalene chromophore. The Two-photon absorption cross-section of our DDS is 142 GM at 850 nm. The DDS was converted into pure organic nanoparticles for biological applications. Our nano-DDS is capable of selective targeting, AIE-luminogenic imaging, and drug release within the lysosome. In vitro studies using cancerous cell lines showed that our single component photoresponsive nanocarrier exhibited enhanced cytotoxicity and real-time monitoring ability of the drug release.

Near-infrared light-triggered drug release from UV-responsive diblock copolymer-coated upconversion nanoparticles with high monodispersity

2018 ◽  
Vol 6 (21) ◽  
pp. 3531-3540 ◽  
Author(s):  
Jun Xiang ◽  
Xia Tong ◽  
Feng Shi ◽  
Qiang Yan ◽  
Bing Yu ◽  
...  
Keyword(s):  
Drug Release ◽  
Diblock Copolymer ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Near Infrared Light ◽  
Nir Light ◽  
Triggered Drug Release

The preparation of a new near-infrared (NIR) light-responsive nanocarrier for controlled drug release is demonstrated.

Dual pH-Responsive Polymer Nanogels with a Core–Shell Structure for Improved Cell Association

Langmuir ◽  
2019 ◽  
Vol 35 (51) ◽  
pp. 16869-16875 ◽  
Author(s):  
Haiyan Sui ◽  
Zhiliang Gao ◽  
Jianman Guo ◽  
Yitong Wang ◽  
Jin Yuan ◽  
...  
Keyword(s):  
Shell Structure ◽  
Core Shell ◽  
Ph Responsive ◽  
Cell Association ◽  
Responsive Polymer ◽  
Core Shell Structure
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