scholarly journals DOX sensitized upconversion metal–organic frameworks for the pH responsive release and real-time detection of doxorubicin hydrochloride

RSC Advances ◽  
2020 ◽  
Vol 10 (56) ◽  
pp. 33894-33902
Author(s):  
Feng Tian ◽  
Chen Xu ◽  
Mingyue Xu ◽  
Haiqing Gao ◽  
Ziyi Xiao ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Drug Release ◽  
Cancer Treatment ◽  
Real Time ◽  
Metal Organic Frameworks ◽  
Major Obstacle ◽  
Doxorubicin Hydrochloride ◽  
Ph Responsive ◽  
Metal Organic ◽  
Real Time Detection

Drug resistance is a major obstacle in cancer treatment, and designing a material that monitors real-time drug release remains a top priority.

One-pot synthesis of folic acid encapsulated upconversion nanoscale metal organic frameworks for targeting, imaging and pH responsive drug release

2016 ◽  
Vol 45 (45) ◽  
pp. 18120-18132 ◽  
Author(s):  
Angshuman Ray Chowdhuri ◽  
Dipranjan Laha ◽  
Srimanta Pal ◽  
Parimal Karmakar ◽  
Sumanta Kumar Sahu
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Drug Release ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Ph Responsive ◽  
One Pot ◽  
Anticancer Drug Delivery ◽  
Metal Organic ◽  
One Step

A folic acid conjugated upconversion nanoscale metal organic framework is developed as a smart material in one step for targeted anticancer drug delivery.

Smart metal organic frameworks: Focus on cancer treatment

2021 ◽  
Author(s):  
Monir Falsafi ◽  
Amir Shokooh Saljooghi ◽  
Khalil Abnous ◽  
Seyed Mohammad Taghdisi ◽  
Mohammad Ramezani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Porous Materials ◽  
Metal Clusters ◽  
Metal Organic Frameworks ◽  
Controlled Systems ◽  
Metal Organic

Metal–organic frameworks (MOFs), as a prominent category of hybrid porous materials constructed from metal clusters or ions plus organic linkers, have been broadly employed as controlled systems of drug delivery...

Real-Time Monitoring of Dissolved Oxygen with Inherent Oxygen-Sensitive Centers in Metal–Organic Frameworks

2016 ◽  
Vol 28 (8) ◽  
pp. 2652-2658 ◽  
Author(s):  
Jian Yang ◽  
Zhe Wang ◽  
Yongsheng Li ◽  
Qixin Zhuang ◽  
Jinlou Gu
Keyword(s):  
Dissolved Oxygen ◽  
Real Time ◽  
Metal Organic Frameworks ◽  
Real Time Monitoring ◽  
Oxygen Sensitive ◽  
Metal Organic

Multimodal Cancer Treatment: Real Time Monitoring, Optimization, and Synergistic Effects

2008 ◽  
Vol 7 (5) ◽  
pp. 409-414 ◽  
Author(s):  
Gunnar Myhr
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Adjuvant Therapy ◽  
Ionizing Radiation ◽  
Cancer Treatment ◽  
Real Time ◽  
Treatment System ◽  
Multi Drug Resistance ◽  
Real Time Monitoring ◽  
Site Specific

The primary objective of this analysis is to provide the theoretical framework for a novel multimodal cancer treatment system emphasizing the use of ultrasound as a synergistic drug release mechanism, real time monitoring by MRI of hyperthermic, pO2, and ultrasound induced released effects. The aim is to provide a cure for the 20% of cancer victims who will die of complications from local solid tumors. Adjuvant therapy usually refers to surgery preceding or following chemotherapy and/or ionizing radiation treatment to decrease the risk of recurrence, but the absolute benefit for survival obtained with adjuvant therapy compared to control is only approximately 6%. Tumor hypoxia represents a primary therapeutic concern, besides multi-drug resistance (MDR), because it can reduce the effectiveness of drugs and radiotherapy; well-oxygenated cells require one-third the dose of hypoxic cells to achieve a given level of cell killing. The era of systemic and indiscriminate chemotherapeutic drug delivery into both healthy and pathologic tissues is near an end. Targeted drug delivery using nanoparticles is emerging as the new vehicle, either as a single treatment option, as part of adjuvant procedures or as a component of a multimodal cancer treatment system. There are more than 100 nanosized liposomes or particles, and conjugated anticancer agents in various stages of preclinical and clinical development. Active targeting can be achieved by site-specific delivery or site-specific triggering. Ultrasound can be utilized as both a site triggering and synergistic mechanism in drug release. The process can be monitored using MRI by a physical process called cavitation. An analysis of low frequency ultrasound exposure in combination with liposomally encapsulated doxorubicin (Caelyx) on Balb/c nude mice inoculated with a WiDr (human colon cancer) tumor cell line provided tumor growth inhibition of 30–40%. Mild hyperthermia causes mean intratumor pO2 to increase by 25% and enhances tumor radiosensitization. Hyperthermia causes the extravasation of liposome nanoparticles in deep tumor regions. Ionizing radiation improves the distribution and uptake of drugs. Liposomally encapsulated drugs and ultrasound mediated hyperthermia have been proven to circumvent MDR effects. Hyperthermic effects and pO2 monitoring of bodily fluid have been performed by MRI. It is hypothesized that increased vascularization and subsequent increase in pO2 levels to hypoxic regions, and monitoring of drug release through cavitation, can facilitate optimized real time concomitant or sequential treatments of drug therapy, hyperthermia, ionizing radiation, etc., before or after surgery. An improved therapeutic index with the use of the outlined system seems probable.

Anion directing self-assembly of 2D and 3D water-stable silver(i) cation metal organic frameworks and their applications in real-time discriminating cysteine and DNA detection

2018 ◽  
Vol 6 (28) ◽  
pp. 4569-4574 ◽  
Author(s):  
Xin Rui Wang ◽  
Jing Du ◽  
Zhuo Huang ◽  
Kun Liu ◽  
Yuan Yuan Liu ◽  
...  
Keyword(s):  
Real Time ◽  
Self Assembly ◽  
Dna Detection ◽  
Metal Organic Frameworks ◽  
Metal Organic ◽  
2D And 3D

Two water-stable silver(i) cation metal organic frameworks (MOFs), namely 2D MOF {[Ag(L)2]BF4}n (1) and 3D MOF {[Ag3(L)3]·(H2O)·(CF3SO3)3}n (2) (L = 1-(4-aminobenzyl)-1,2,4-triazole), have been prepared.

A pH-responsive prodrug for real-time drug release monitoring and targeted cancer therapy

2014 ◽  
Vol 50 (80) ◽  
pp. 11852-11855 ◽  
Author(s):  
Shi-Ying Li ◽  
Li-Han Liu ◽  
Hui-Zhen Jia ◽  
Wen-Xiu Qiu ◽  
Lei Rong ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Real Time ◽  
Targeted Cancer Therapy ◽  
Ph Responsive
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