Enzymatic conversion of magnetic nanoparticles to a non-magnetic precipitate: a new approach to magnetic sensing

The Analyst ◽  
2016 ◽  
Vol 141 (18) ◽  
pp. 5246-5251 ◽  
Author(s):  
Arati G. Kolhatkar ◽  
Andrew C. Jamison ◽  
Ivan Nekrashevich ◽  
Katerina Kourentzi ◽  
Dmitri Litvinov ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Enzymatic Conversion ◽  
Magnetic Sensing ◽  
New Approach ◽  
Enzymatic Transformation

Magnetic sensing utilizes loss of signal via enzymatic transformation of magnetic nanoparticles (MNPs).

A new approach for bioassays based on frequency- and time-domain measurements of magnetic nanoparticles

2010 ◽  
Vol 25 (5) ◽  
pp. 1008-1013 ◽  
Author(s):  
Fredrik Öisjöen ◽  
Justin F. Schneiderman ◽  
Andrea Prieto Astalan ◽  
Alexey Kalabukhov ◽  
Christer Johansson ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Time Domain ◽  
New Approach

scholarly journals Enzymatic Transformation of Phosphate Decorated Magnetic Nanoparticles for Selectively Sorting and Inhibiting Cancer Cells

2014 ◽  
Vol 25 (12) ◽  
pp. 2129-2133 ◽  
Author(s):  
Xuewen Du ◽  
Jie Zhou ◽  
Liheng Wu ◽  
Shouheng Sun ◽  
Bing Xu
Keyword(s):  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Enzymatic Transformation

New approach for understanding experimental NMR relaxivity properties of magnetic nanoparticles: focus on cobalt ferrite

2016 ◽  
Vol 18 (48) ◽  
pp. 32981-32991 ◽  
Author(s):  
Anne-Laure Rollet ◽  
Sophie Neveu ◽  
Patrice Porion ◽  
Vincent Dupuis ◽  
Nadine Cherrak ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Cobalt Ferrite ◽  
Nmr Relaxation ◽  
New Approach

Relaxivities r1 and r2 of cobalt ferrite magnetic nanoparticles (MNPs) have been investigated in the aim of improving the models of NMR relaxation induced by magnetic nanoparticles.

scholarly journals Magnetic nanoparticles as a new approach to improve the efficacy of gene therapy against differentiated human uterine fibroid cells and tumor-initiating stem cells

2016 ◽  
Vol 105 (6) ◽  
pp. 1638-1648.e8 ◽  
Author(s):  
Shahinaz Mahmood Shalaby ◽  
Mostafa K. Khater ◽  
Aymara Mas Perucho ◽  
Sara A. Mohamed ◽  
Inas Helwa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Magnetic Nanoparticles ◽  
Uterine Fibroid ◽  
New Approach

scholarly journals A new approach for highly accurate, remote temperature probing using magnetic nanoparticles

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Jing Zhong ◽  
Wenzhong Liu ◽  
Li Kong ◽  
Paulo Cesar Morais
Keyword(s):  
Magnetic Nanoparticles ◽  
New Approach

scholarly journals A Smart Hyperthermia Nanofiber-Platform-Enabled Sustained Release of Doxorubicin and 17AAG for Synergistic Cancer Therapy

2021 ◽  
Vol 22 (5) ◽  
pp. 2542
Author(s):  
Lili Chen ◽  
Nanami Fujisawa ◽  
Masato Takanohashi ◽  
Mazaya Najmina ◽  
Koichiro Uto ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Magnetic Composite ◽  
Therapeutic Effects ◽  
Protein Activity ◽  
New Approach ◽  
Molecularly Targeted Therapy ◽  
Medication Delivery ◽  
Composite Nanofiber ◽  
Biodegradable Poly

This study demonstrates the rational fabrication of a magnetic composite nanofiber mesh that can achieve mutual synergy of hyperthermia, chemotherapy, and thermo-molecularly targeted therapy for highly potent therapeutic effects. The nanofiber is composed of biodegradable poly(ε-caprolactone) with doxorubicin, magnetic nanoparticles, and 17-allylamino-17-demethoxygeldanamycin. The nanofiber exhibits distinct hyperthermia, owing to the presence of magnetic nanoparticles upon exposure of the mesh to an alternating magnetic field, which causes heat-induced cell killing as well as enhanced chemotherapeutic efficiency of doxorubicin. The effectiveness of hyperthermia is further enhanced through the inhibition of heat shock protein activity after hyperthermia by releasing the inhibitor 17-allylamino-17-demethoxygeldanamycin. These findings represent a smart nanofiber system for potent cancer therapy and may provide a new approach for the development of localized medication delivery.

RF heating of magnetic nanoparticles improves the thawing of cryopreserved biomaterials

TECHNOLOGY ◽  
2014 ◽  
Vol 02 (03) ◽  
pp. 229-242 ◽  
Author(s):  
Michael L. Etheridge ◽  
Yi Xu ◽  
Leoni Rott ◽  
Jeunghwan Choi ◽  
Birgit Glasmacher ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Great Promise ◽  
Rf Heating ◽  
Practical Application ◽  
Micro Computed Tomography ◽  
Heating Rates ◽  
Scanning Calorimetry ◽  
New Approach ◽  
Minimal Impact ◽  
Quality Control Tool

While vitrified cryopreservation holds great promise, practical application has been limited to smaller systems (cells and thin tissues) due to diffusive heat and mass transfer limitations, which are typically manifested as devitrification and cracking failures during thaw. Here then we describe a new approach for rapidly and uniformly heating cryopreserved biospecimens with radiofrequency (RF) excited magnetic nanoparticles (mNPs). Importantly, heating rates can be increased several fold over conventional boundary heating techniques and are independent of sample size. Initial differential scanning calorimetry studies indicate that the addition of the mNPs has minimal impact on the freeze-thaw behavior of the cryoprotectant systems themselves. Then proof-of-principle experiments in aqueous and cryoprotectant solutions demonstrate the ability to heat at rates high enough to mitigate or eliminate devitrification (hundreds of °C/min) and scaled heat transfer modeling is used to illustrate the potential of this innovative approach. Finally, X-ray micro-computed-tomography (micro-CT) is investigated as a planning and quality control tool, where the density-based measurements are able to quantify changes in cryoprotectant concentration, mNP concentration, and the frozen state (i.e. crystallized versus vitrified).

scholarly journals Enzyme transformation to modulate the ligand–receptor interactions between small molecules

2015 ◽  
Vol 51 (23) ◽  
pp. 4899-4901 ◽  
Author(s):  
Junfeng Shi ◽  
Xuewen Du ◽  
Dan Yuan ◽  
Richard Haburcak ◽  
Dongdong Wu ◽  
...  
Keyword(s):  
Small Molecules ◽  
Living Systems ◽  
New Approach ◽  
Enzymatic Transformation ◽  
Receptor Interactions

The use of enzymatic transformation to regulate ligand–receptor interactions between small molecules represents a new approach to mimic the essence of living systems.

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