scholarly journals Enzymatic Transformation of Phosphate Decorated Magnetic Nanoparticles for Selectively Sorting and Inhibiting Cancer Cells

2014 ◽  
Vol 25 (12) ◽  
pp. 2129-2133 ◽  
Author(s):  
Xuewen Du ◽  
Jie Zhou ◽  
Liheng Wu ◽  
Shouheng Sun ◽  
Bing Xu
Keyword(s):  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Enzymatic Transformation

Co-delivery of Doxorubicin and D-α-Tocopherol Polyethylene Glycol 1000 Succinate by Magnetic Nanoparticles

2018 ◽  
Vol 18 (8) ◽  
pp. 1138-1147 ◽  
Author(s):  
Esra Metin ◽  
Pelin Mutlu ◽  
Ufuk Gündüz
Keyword(s):  
Breast Cancer ◽  
Polyethylene Glycol ◽  
Magnetic Nanoparticles ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Drug Loading ◽  
Gravimetric Analysis ◽  
Polyethylene Glycol 1000 ◽  
Mcf 7

Background: Although conventional chemotherapy is the most common method for cancer treatment, it has several side effects such as neuropathy, alopecia and cardiotoxicity. Since the drugs are given to body systemically, normal cells are also affected, just like cancer cells. However, in recent years, targeted drug delivery has been developed to overcome these drawbacks. Objective: The aim of this study was targeted co-delivery of doxorubicin (Dox) which is an anticancer agent and D-α-Tocopherol polyethylene glycol 1000 succinate (vitamin E TPGS or simply TPGS) to breast cancer cells. For this purpose, Magnetic Nanoparticles (MNPs) were synthesized and coated with Oleic Acid (OA). Coated nanoparticles were encapsulated in Poly Lactic-co-Glycolic Acid (PLGA) and TPGS polymers and loaded with Dox. The Nanoparticles (NPs) were characterized by Fourier Transform Infrared (FTIR) spectroscopy, zetapotential analysis, Dynamic Light Scattering (DLS) analysis, Thermal Gravimetric Analysis (TGA) and Scanning Electron Microscope (SEM) analysis. Results: The results showed that NPs were spherical, superparamagnetic and in the desired range for use in drug targeting. The targetability of NPs was confirmed. Moreover, TPGS and Dox loading was shown by TGA and FTIR analyses. NPs were internalized by cells and the cytotoxic effect of drug loaded NPs on sensitive (MCF-7) and drug-resistant (MCF-7/Dox) cells were examined. It was seen that the presence of TPGS increased cytotoxicity significantly. TPGS also enhanced drug loading efficiency, release rate, cellular internalization. In MCF- 7/Dox cells, the drug resistance seems to be decreased when Dox is loaded onto TPGS containing NPs. Conclusion: This magnetic PLGA nanoparticle system is important for new generation targeted chemotherapy and could be used for breast cancer treatment after in vivo tests.

scholarly journals A Feasibility Study of Nonlinear Spectroscopic Measurement of Magnetic Nanoparticles Targeted to Cancer Cells

2017 ◽  
Vol 64 (5) ◽  
pp. 972-979 ◽  
Author(s):  
Bradley W. Ficko ◽  
Christian NDong ◽  
Paolo Giacometti ◽  
Karl E. Griswold ◽  
Solomon G. Diamond
Keyword(s):  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Feasibility Study ◽  
Spectroscopic Measurement

scholarly journals Magnetic nanoparticle-conjugated polymeric micelles for combined hyperthermia and chemotherapy

Nanoscale ◽  
2015 ◽  
Vol 7 (39) ◽  
pp. 16470-16480 ◽  
Author(s):  
Hyun-Chul Kim ◽  
Eunjoo Kim ◽  
Sang Won Jeong ◽  
Tae-Lin Ha ◽  
Sang-Im Park ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Synergistic Effect ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Magnetic Nanoparticle ◽  
Polymeric Micelles ◽  
Alternating Magnetic Field ◽  
Rapid Release

The cytotoxicity of magnetic nanoparticles-conjugated polymeric micelles encapsulated with an anticancer drug on cancer cells was enhanced by the synergistic effect of heat and the rapid release of the drug under an alternating magnetic field.

scholarly journals Pattern Recognition of Cancer Cells Using Aptamer-Conjugated Magnetic Nanoparticles

ACS Nano ◽  
2012 ◽  
Vol 6 (5) ◽  
pp. 3974-3981 ◽  
Author(s):  
Suwussa Bamrungsap ◽  
Tao Chen ◽  
Mohammed Ibrahim Shukoor ◽  
Zhuo Chen ◽  
Kwame Sefah ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Magnetic Nanoparticles ◽  
Cancer Cells

scholarly journals Smart magnetic nanopowder based on the manganite perovskite for local hyperthermia

RSC Advances ◽  
2020 ◽  
Vol 10 (51) ◽  
pp. 30907-30916
Author(s):  
A. V. Pashchenko ◽  
N. A. Liedienov ◽  
I. V. Fesych ◽  
Quanjun Li ◽  
V. G. Pitsyuga ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Local Heating ◽  
Local Hyperthermia ◽  
Manganite Perovskite ◽  
Short Time

Local heating of cancer cells up to 42 °C for a short time (∼1.5 min) by smart magnetic nanoparticles.

scholarly journals Silibinin-loaded magnetic nanoparticles inhibit hTERT gene expression and proliferation of lung cancer cells

2017 ◽  
Vol 45 (8) ◽  
pp. 1649-1656 ◽  
Author(s):  
Soumaye Amirsaadat ◽  
Younes Pilehvar-Soltanahmadi ◽  
Faraz Zarghami ◽  
Shahriar Alipour ◽  
Zohreh Ebrahimnezhad ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Htert Gene

Selective removal of ovarian cancer cells from human ascites fluid using magnetic nanoparticles

2010 ◽  
Vol 6 (3) ◽  
pp. 399-408 ◽  
Author(s):  
Kenneth E. Scarberry ◽  
Erin B. Dickerson ◽  
Z. John Zhang ◽  
Benedict B. Benigno ◽  
John F. McDonald
Keyword(s):  
Ovarian Cancer ◽  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Selective Removal ◽  
Ascites Fluid ◽  
Ovarian Cancer Cells
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