Comb-like poly(l-cysteine) derivatives with different side groups: synthesis via photochemistry and click chemistry, multi-responsive nanostructures, triggered drug release and cytotoxicity

2015 ◽  
Vol 6 (38) ◽  
pp. 6857-6869 ◽  
Author(s):  
Xingjie Wu ◽  
Linzhu Zhou ◽  
Yue Su ◽  
Chang-Ming Dong
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Click Chemistry ◽  
On Demand ◽  
Triggered Drug Release ◽  
Ene Addition

A series of comb-like graft polypeptides having different side groups and tunable grafting ratios were prepared by sequential photocleavage reactions and Michael-type thiol–ene addition, which provides a promising platform for on-demand nanomedicine and cancer therapy.

NIR-responsive polypeptide copolymer upconversion composite nanoparticles for triggered drug release and enhanced cytotoxicity

2015 ◽  
Vol 6 (21) ◽  
pp. 4030-4039 ◽  
Author(s):  
Gang Liu ◽  
Na Liu ◽  
Linzhu Zhou ◽  
Yue Su ◽  
Chang-Ming Dong
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Near Infrared ◽  
Composite Nanoparticles ◽  
Infrared Light ◽  
Near Infrared Light ◽  
On Demand ◽  
Triggered Drug Release

Near infrared light-responsive polypeptide copolymer upconversion composite nanoparticles exhibited controllable drug release and triggered cytotoxicity useful for on-demand drug delivery and cancer therapy.

A pH-responsive AIE nanoprobe as a drug delivery system for bioimaging and cancer therapy

2015 ◽  
Vol 3 (37) ◽  
pp. 7401-7407 ◽  
Author(s):  
Haibo Wang ◽  
Gongyan Liu ◽  
Shihua Dong ◽  
Junjie Xiong ◽  
Zongliang Du ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cellular Imaging ◽  
Ph Responsive ◽  
Triggered Drug Release

A multifunctional drug delivery system with AIE character was designed and constructed for simultaneous cellular imaging and pH-triggered drug release.

Dual-triggered drug-release vehicles for synergistic cancer therapy

2019 ◽  
Vol 173 ◽  
pp. 788-797 ◽  
Author(s):  
Ting-Yu Tu ◽  
Shu-Jyuan Yang ◽  
Ming-Hsien Tsai ◽  
Chung-Hao Wang ◽  
Shin-Yu Lee ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Triggered Drug Release

Near-infrared laser-triggered drug release in tellurium nanosystem for simultaneous chemo-photothermal cancer therapy

2021 ◽  
Author(s):  
Linqi Duan ◽  
Ting Liu ◽  
Tianfeng Chen
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Tumor Cells ◽  
Clinical Application ◽  
Near Infrared ◽  
Infrared Laser ◽  
Normal Cells ◽  
Triggered Drug Release

Tumor cells can be selectively killed by the different tolerance of normal cells and tumor cells to temperature. However, the limited clinical application of PTT is mainly due to various...

scholarly journals Gold Nanocage-Incorporated Poly(ε-Caprolactone) (PCL) Fibers for Chemophotothermal Synergistic Cancer Therapy

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 60 ◽  
Author(s):  
Ju Park ◽  
Hojun Seo ◽  
Da Kim ◽  
Ji Choi ◽  
Jin Son ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cancer Therapy ◽  
Drug Release ◽  
Near Infrared ◽  
Hyperthermia Treatment ◽  
Anticancer Efficacy ◽  
Drug Molecules ◽  
Nir Light ◽  
Rapid Release ◽  
Triggered Drug Release

This paper introduces a new fibrous system for synergistic cancer therapy, which consists of gold nanocage (AuNC)-loaded poly(ε-caprolactone) (PCL) fibers with encapsulation of a chemotherapeutic anticancer drug in their core and loading of a phase-changeable fatty acid in their sheath. Under on–off switching of near-infrared (NIR) light irradiation, the excellent photothermal ability and photostability of AuNCs allows repeated, significant heating of the fibers to a temperature available to hyperthermia. Simultaneously, the NIR light-induced heat generation enables the melting out of the loaded fatty acid, leading to a rapid release of the drug molecules from the fibers. The combination of this NIR light-triggered drug release with the repeated hyperthermia treatment exhibits excellent anticancer efficacy.

Hypoxia- and singlet oxygen-responsive chemo-photodynamic Micelles featured with glutathione depletion and aldehyde production

2019 ◽  
Vol 7 (1) ◽  
pp. 429-441 ◽  
Author(s):  
Jian Deng ◽  
Fang Liu ◽  
Lina Wang ◽  
Yang An ◽  
Min Gao ◽  
...  
Keyword(s):  
Drug Release ◽  
Singlet Oxygen ◽  
Glutathione Depletion ◽  
Efficient Approach ◽  
On Demand ◽  
Triggered Drug Release ◽  
Drug Liberation

Triggered drug release from anti-tumor nanomedicine is an efficient approach to address the dilemma of systemic nanocarrier stability and on-demand drug liberation in tumor sites.

Reduction-active polymeric prodrug micelles based on α-cyclodextrin polyrotaxanes for triggered drug release and enhanced cancer therapy

2018 ◽  
Vol 193 ◽  
pp. 153-162 ◽  
Author(s):  
Shuang Bai ◽  
Meili Hou ◽  
Xiaoxiao Shi ◽  
Jiucun Chen ◽  
Xiaoqian Ma ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Polymeric Prodrug ◽  
Triggered Drug Release

Photodynamic therapy-mediated remote control of chemotherapy toward synergistic anticancer treatment

Nanoscale ◽  
2018 ◽  
Vol 10 (30) ◽  
pp. 14554-14562 ◽  
Author(s):  
Yongjuan Li ◽  
Shixian Lv ◽  
Ziyuan Song ◽  
Juanjuan Dang ◽  
Xudong Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Remote Control ◽  
Cancer Therapy ◽  
Drug Release ◽  
Stimuli Responsive ◽  
On Demand ◽  
Release Property ◽  
Anticancer Treatment

Stimuli-responsive nanomedicine (NM) with an on-demand drug release property has demonstrated promising utility toward cancer therapy.

Red and NIR Light-Responsive Polymeric Nanocarriers for On-Demand Drug Delivery

2020 ◽  
Vol 27 (23) ◽  
pp. 3877-3887
Author(s):  
Xinyu He ◽  
Xianzhu Yang ◽  
Dongdong Li ◽  
Ziyang Cao
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Uptake ◽  
Design Strategies ◽  
Polymeric Nanocarriers ◽  
Normal Tissues ◽  
On Demand ◽  
Nir Light

Red and NIR light-responsive polymeric nanocarriers capable of on-demand drug delivery have gained tremendous attention for their great potential in cancer therapy. Various strategies have been applied to fabricate such nanocarriers, and they have demonstrated significant therapeutic efficacy and minimal toxicity to normal tissues. Here, we will review the current developments in various red and NIR light-responsive polymeric nanocarriers with respect to their use in on-demand drug delivery, including facilitation of drug internalization and boosting of drug release at targeted sites. We summarize their components and design strategies, and highlight the mechanisms by which the photoactivatable variations enhance drug uptake and drug release. We attempt to provide new insights into the fabrication of red and NIR light-responsive polymeric nanocarriers for on-demand drug delivery.

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