The rational design of NAMI-A-loaded mesoporous silica nanoparticles as antiangiogenic nanosystems

2015 ◽  
Vol 3 (30) ◽  
pp. 6338-6346 ◽  
Author(s):  
Hao Hu ◽  
Yuanyuan You ◽  
Lizhen He ◽  
Tianfeng Chen
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Rational Design ◽  
Mesoporous Silica Nanoparticles ◽  
Antiangiogenic Activity

Herein we demonstrate the use of RGD-modified MSNs as a vehicle for anticancer drugs to achieve enhanced antiangiogenic activity.

scholarly journals Rational Design of Monodisperse Mesoporous Silica Nanoparticles for Phytase Immobilization

ACS Omega ◽  
2020 ◽  
Vol 5 (46) ◽  
pp. 30237-30242
Author(s):  
Chunling Xin ◽  
Xia Wang ◽  
LiLi Liu ◽  
Jinmei Yang ◽  
Suqing Wang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Rational Design ◽  
Mesoporous Silica Nanoparticles

Hierarchical integration of degradable mesoporous silica nanoreservoirs and supramolecular dendrimer complex as a general-purpose tumor-targeted biomimetic nanoplatform for gene/small-molecule anticancer drug co-delivery

Nanoscale ◽  
2020 ◽  
Vol 12 (30) ◽  
pp. 16102-16112 ◽  
Author(s):  
Yang Fei ◽  
Menghuan Li ◽  
Yanan Li ◽  
Xuan Wang ◽  
Chencheng Xue ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Small Molecule ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
General Purpose

A biomimetic nanosystem was developed through the hierarchical integration of degradable dendritic mesoporous silica nanoparticles and functional dendrimers for the tumor-targeted delivery of genes and small-molecule anticancer drugs.

Codelivery of anticancer drugs and siRNA by mesoporous silica nanoparticles

2016 ◽  
Vol 7 (9) ◽  
pp. 649-655 ◽  
Author(s):  
Mohammad Yahya Hanafi-Bojd ◽  
Legha Ansari ◽  
Bizhan Malaekeh-Nikouei
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Mesoporous Silica Nanoparticles

Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs

Small ◽  
2007 ◽  
Vol 3 (8) ◽  
pp. 1341-1346 ◽  
Author(s):  
Jie Lu ◽  
Monty Liong ◽  
Jeffrey I. Zink ◽  
Fuyuhiko Tamanoi
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Hydrophobic Anticancer Drugs

Dual responsive mesoporous silica nanoparticles for targeted co-delivery of hydrophobic and hydrophilic anticancer drugs to tumor cells

2016 ◽  
Vol 4 (25) ◽  
pp. 4382-4388 ◽  
Author(s):  
Xin Chen ◽  
Zhongning Liu
Keyword(s):  
Drug Resistance ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Anticancer Drugs ◽  
Tumor Targeting ◽  
Mesoporous Silica Nanoparticles ◽  
Dual Responsive

Dual responsive mesoporous silica nanoparticles integrating stepwise tumor targeting and co-delivery of multiple anticancer drugs were developed to attenuate the drug resistance of cancer cells.

scholarly journals Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles

Pharmaceutics ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 30 ◽  
Author(s):  
Diana Díaz-García ◽  
Perla Ardiles ◽  
Sanjiv Prashar ◽  
Antonio Rodríguez-Diéguez ◽  
Paulina Páez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Catalytic Oxidation ◽  
Rational Design ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carriers ◽  
Stress Generation ◽  
Bacterial Cells ◽  
Oxidation Activity

Mesoporous silica nanoparticles (MSNs) are an interesting class of nanomaterials with potential applications in different therapeutic areas and that have been extensively used as drug carriers in different fields of medicine. The present work is focused on the synthesis of MSNs containing a maleamato ligand (MSN-maleamic) and the subsequent coordination of copper(II) ions (MSN-maleamic-Cu) for the exploration of their potential application as antibacterial agents. The Cu-containing nanomaterials have been characterized by different techniques and the preliminary antibacterial effect of the supported maleamato-copper(II) complexes has been tested against two types of bacteria (Gram positive and Gram negative) in different assays to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The biological results showed a moderate antibacterial activity against Escherichia coli which motivated a more detailed study of the antibacterial mechanism of action of the synthesized maleamate-containing nanosystems and whose findings showed oxidative stress generation in bacterial cells. All the prepared nanomaterials were also tested as catalysts in the “solvent free” selective oxidation of benzyl alcohol, to observe if there is a potential correlation between the catalytic oxidation capacity of the materials and the observed oxidative stress in bacteria. This may help in the future, for a more accurate rational design of antibacterial nanosystems, based on their observed catalytic oxidation activity.

Sign in / Sign up

Export Citation Format

Share Document