Rational Design of Multifunctional Dendritic Mesoporous Silica Nanoparticles to Load Curcumin and Enhance Efficacy for Breast Cancer Therapy

2016 ◽  
Vol 8 (40) ◽  
pp. 26511-26523 ◽  
Author(s):  
Jiao Wang ◽  
Yue Wang ◽  
Qiang Liu ◽  
Linnan Yang ◽  
Rongrong Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Rational Design ◽  
Mesoporous Silica Nanoparticles ◽  
Breast Cancer Therapy

Synthesis of lactoferrin mesoporous silica nanoparticles for pemetrexed/ellagic acid synergistic breast cancer therapy

2020 ◽  
Vol 188 ◽  
pp. 110824 ◽  
Author(s):  
Omnia M. Ali ◽  
Adnan A. Bekhit ◽  
Sherine N. Khattab ◽  
Maged W. Helmy ◽  
Yasser S. Abdel-Ghany ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Ellagic Acid ◽  
Mesoporous Silica Nanoparticles ◽  
Breast Cancer Therapy

scholarly journals Rational Design of Monodisperse Mesoporous Silica Nanoparticles for Phytase Immobilization

ACS Omega ◽  
2020 ◽  
Vol 5 (46) ◽  
pp. 30237-30242
Author(s):  
Chunling Xin ◽  
Xia Wang ◽  
LiLi Liu ◽  
Jinmei Yang ◽  
Suqing Wang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Rational Design ◽  
Mesoporous Silica Nanoparticles

scholarly journals Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 71
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Agents ◽  
Metal Species ◽  
Stimuli Responsive ◽  
Combination Drug ◽  
Incidence And Mortality

With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

scholarly journals Cationic Polymer Modified Mesoporous Silica Nanoparticles for Targeted siRNA Delivery to HER2+Breast Cancer

2015 ◽  
Vol 25 (18) ◽  
pp. 2646-2659 ◽  
Author(s):  
Worapol Ngamcherdtrakul ◽  
Jingga Morry ◽  
Shenda Gu ◽  
David J. Castro ◽  
Shaun M. Goodyear ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Sirna Delivery ◽  
Cationic Polymer ◽  
Her2 Breast Cancer
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