Codelivery of anticancer drugs and siRNA by mesoporous silica nanoparticles

2016 ◽  
Vol 7 (9) ◽  
pp. 649-655 ◽  
Author(s):  
Mohammad Yahya Hanafi-Bojd ◽  
Legha Ansari ◽  
Bizhan Malaekeh-Nikouei
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Mesoporous Silica Nanoparticles

Hierarchical integration of degradable mesoporous silica nanoreservoirs and supramolecular dendrimer complex as a general-purpose tumor-targeted biomimetic nanoplatform for gene/small-molecule anticancer drug co-delivery

Nanoscale ◽  
2020 ◽  
Vol 12 (30) ◽  
pp. 16102-16112 ◽  
Author(s):  
Yang Fei ◽  
Menghuan Li ◽  
Yanan Li ◽  
Xuan Wang ◽  
Chencheng Xue ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Small Molecule ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
General Purpose

A biomimetic nanosystem was developed through the hierarchical integration of degradable dendritic mesoporous silica nanoparticles and functional dendrimers for the tumor-targeted delivery of genes and small-molecule anticancer drugs.

The rational design of NAMI-A-loaded mesoporous silica nanoparticles as antiangiogenic nanosystems

2015 ◽  
Vol 3 (30) ◽  
pp. 6338-6346 ◽  
Author(s):  
Hao Hu ◽  
Yuanyuan You ◽  
Lizhen He ◽  
Tianfeng Chen
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Rational Design ◽  
Mesoporous Silica Nanoparticles ◽  
Antiangiogenic Activity

Herein we demonstrate the use of RGD-modified MSNs as a vehicle for anticancer drugs to achieve enhanced antiangiogenic activity.

Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs

Small ◽  
2007 ◽  
Vol 3 (8) ◽  
pp. 1341-1346 ◽  
Author(s):  
Jie Lu ◽  
Monty Liong ◽  
Jeffrey I. Zink ◽  
Fuyuhiko Tamanoi
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Hydrophobic Anticancer Drugs

Dual responsive mesoporous silica nanoparticles for targeted co-delivery of hydrophobic and hydrophilic anticancer drugs to tumor cells

2016 ◽  
Vol 4 (25) ◽  
pp. 4382-4388 ◽  
Author(s):  
Xin Chen ◽  
Zhongning Liu
Keyword(s):  
Drug Resistance ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Anticancer Drugs ◽  
Tumor Targeting ◽  
Mesoporous Silica Nanoparticles ◽  
Dual Responsive

Dual responsive mesoporous silica nanoparticles integrating stepwise tumor targeting and co-delivery of multiple anticancer drugs were developed to attenuate the drug resistance of cancer cells.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

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