Isomer-Dependent Adsorption and Release of Cis-and Trans-platin Anticancer Drugs by Mesoporous Silica Nanoparticles

Langmuir ◽  
2010 ◽  
Vol 26 (11) ◽  
pp. 8914-8924 ◽  
Author(s):  
Zhimin Tao ◽  
Youwei Xie ◽  
Jerry Goodisman ◽  
Tewodros Asefa
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Mesoporous Silica Nanoparticles ◽  
Adsorption And Release ◽  
Cis And Trans

Hierarchical integration of degradable mesoporous silica nanoreservoirs and supramolecular dendrimer complex as a general-purpose tumor-targeted biomimetic nanoplatform for gene/small-molecule anticancer drug co-delivery

Nanoscale ◽  
2020 ◽  
Vol 12 (30) ◽  
pp. 16102-16112 ◽  
Author(s):  
Yang Fei ◽  
Menghuan Li ◽  
Yanan Li ◽  
Xuan Wang ◽  
Chencheng Xue ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Small Molecule ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
General Purpose

A biomimetic nanosystem was developed through the hierarchical integration of degradable dendritic mesoporous silica nanoparticles and functional dendrimers for the tumor-targeted delivery of genes and small-molecule anticancer drugs.

Mesoporous Silica Nanoparticles and Waste Derived-Siliceous Materials for Doxorubicin Adsorption and Release

2019 ◽  
Vol 19 ◽  
pp. 1420-1425
Author(s):  
Jafreena Adira Jaafar ◽  
Nur Hidayatul Nazirah Kamarudin ◽  
Herma Dina Setiabudi ◽  
Sharifah Najiha Timmiati ◽  
Teh Lee Peng
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Adsorption And Release

Codelivery of anticancer drugs and siRNA by mesoporous silica nanoparticles

2016 ◽  
Vol 7 (9) ◽  
pp. 649-655 ◽  
Author(s):  
Mohammad Yahya Hanafi-Bojd ◽  
Legha Ansari ◽  
Bizhan Malaekeh-Nikouei
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Mesoporous Silica Nanoparticles

The rational design of NAMI-A-loaded mesoporous silica nanoparticles as antiangiogenic nanosystems

2015 ◽  
Vol 3 (30) ◽  
pp. 6338-6346 ◽  
Author(s):  
Hao Hu ◽  
Yuanyuan You ◽  
Lizhen He ◽  
Tianfeng Chen
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Rational Design ◽  
Mesoporous Silica Nanoparticles ◽  
Antiangiogenic Activity

Herein we demonstrate the use of RGD-modified MSNs as a vehicle for anticancer drugs to achieve enhanced antiangiogenic activity.

Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs

Small ◽  
2007 ◽  
Vol 3 (8) ◽  
pp. 1341-1346 ◽  
Author(s):  
Jie Lu ◽  
Monty Liong ◽  
Jeffrey I. Zink ◽  
Fuyuhiko Tamanoi
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Hydrophobic Anticancer Drugs

Dual responsive mesoporous silica nanoparticles for targeted co-delivery of hydrophobic and hydrophilic anticancer drugs to tumor cells

2016 ◽  
Vol 4 (25) ◽  
pp. 4382-4388 ◽  
Author(s):  
Xin Chen ◽  
Zhongning Liu
Keyword(s):  
Drug Resistance ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Anticancer Drugs ◽  
Tumor Targeting ◽  
Mesoporous Silica Nanoparticles ◽  
Dual Responsive

Dual responsive mesoporous silica nanoparticles integrating stepwise tumor targeting and co-delivery of multiple anticancer drugs were developed to attenuate the drug resistance of cancer cells.

scholarly journals Adsorption and Release of Sulfamethizole from Mesoporous Silica Nanoparticles Functionalised with Triethylenetetramine

2021 ◽  
Vol 22 (14) ◽  
pp. 7665
Author(s):  
Cristina Carucci ◽  
Nicola Scalas ◽  
Andrea Porcheddu ◽  
Marco Piludu ◽  
Maura Monduzzi ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Intermolecular Interactions ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Lower Surface ◽  
Burst Release ◽  
Vis Spectroscopy ◽  
Adsorption And Release

Mesoporous silica nanoparticles (MSN) were synthesised and functionalised with triethylenetetramine (MSN-TETA). The samples were fully characterised (transmission electron microscopy, small angle X-ray scattering, Fourier transform infrared spectroscopy, thermogravimetric analysis, zeta potential and nitrogen adsorption/desorption isotherms) and used as carriers for the adsorption of the antimicrobial drug sulphamethizole (SMZ). SMZ loading, quantified by UV–Vis spectroscopy, was higher on MSN-TETA (345.8 mg g−1) compared with bare MSN (215.4 mg g−1) even in the presence of a lower surface area (671 vs. 942 m2 g−1). The kinetics of SMZ adsorption on MSN and MSN-TETA followed a pseudo-second-order model. The adsorption isotherm is described better by a Langmuir model rather than a Temkin or Freundlich model. Release kinetics showed a burst release of SMZ from bare MSN samples (k1 = 136 h−1) in contrast to a slower release found with MSN-TETA (k1 = 3.04 h−1), suggesting attractive intermolecular interactions slow down SMZ release from MSN-TETA. In summary, the MSN surface area did not influence SMZ adsorption and release. On the contrary, the design of an effective drug delivery system must consider the intermolecular interactions between the adsorbent and the adsorbate.

Elucidation of acid strength effect on ibuprofen adsorption and release by aluminated mesoporous silica nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (38) ◽  
pp. 30023-30031 ◽  
Author(s):  
N. H. N. Kamarudin ◽  
A. A. Jalil ◽  
S. Triwahyono ◽  
M. R. Sazegar ◽  
S. Hamdan ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Acid Strength ◽  
Ft Ir ◽  
Adsorption And Release ◽  
Strength Effect

Mesoporous silica nanoparticles (MSN) with 1–10 wt% loading of aluminum (Al) were prepared and characterized by XRD, N2 physisorption, 29Si and 27Al NMR, FT-IR and FT-IR preadsorbed pyridine.

Adsorption and Release of 5-Fluorouracil (5FU) from Mesoporous Silica Nanoparticles

2019 ◽  
Vol 19 ◽  
pp. 1722-1729 ◽  
Author(s):  
Nur Syazaliyana Azali ◽  
Nur Hidayatul Nazirah Kamarudin ◽  
Ainul Rasyidah Abdul Rahim ◽  
Norzaidhatul Syifa'a Jamal Nasir ◽  
Sharifah Najiha Timmiati ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Adsorption And Release
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