Configurable lipid membrane gradients quantify diffusion, phase separations and binding densities

Soft Matter ◽  
2015 ◽  
Vol 11 (42) ◽  
pp. 8217-8220 ◽  
Author(s):  
Katherine N. Liu ◽  
Chen-min S. Hung ◽  
Michael A. Swift ◽  
Kristen A. Muñoz ◽  
Jose L. Cortez ◽  
...  
Keyword(s):  
Lipid Membrane ◽  
Phospholipid Membranes ◽  
Phase Separations ◽  
Diffusion Phase

Tunable collisions between spreading phospholipid membranes form functional gradients.

scholarly journals Configurable Lipid Membrane Gradients Quantify Diffusion, Phase Separations and Binding Densities

2016 ◽  
Vol 110 (3) ◽  
pp. 17a
Author(s):  
Katherine N. Liu ◽  
Chen-Min S. Hung ◽  
Michael A. Swift ◽  
Kristen A. Muñoz ◽  
Jose L. Cortez ◽  
...  
Keyword(s):  
Lipid Membrane ◽  
Phase Separations ◽  
Diffusion Phase

Phase separations in phospholipid membranes

Biochemistry ◽  
1975 ◽  
Vol 14 (4) ◽  
pp. 847-854 ◽  
Author(s):  
Stephen H. W. Wu ◽  
Harden M. McConnell
Keyword(s):  
Phospholipid Membranes ◽  
Phase Separations

scholarly journals The insertion of human apolipoprotein H into phospholipid membranes: a monolayer study

1998 ◽  
Vol 335 (2) ◽  
pp. 225-232 ◽  
Author(s):  
Shao-Xiong WANG ◽  
Guo-ping CAI ◽  
Sen-fang SUI
Keyword(s):  
Lipid Membrane ◽  
Hydrophobic Interactions ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Heat Inactivation ◽  
Sequence Motif ◽  
Phospholipid Membranes ◽  
Human Apolipoprotein ◽  
Stable Domain ◽  
Apolipoprotein H

Apolipoprotein H (ApoH) is a plasma glycoprotein isolated from human serum. The interactions of ApoH with lipid membrane were reported to be essential for its physiological and pathogenic roles. In this paper we studied the ability of ApoH to insert into phospholipid membranes using the monolayer approach. The results show that ApoH is surface active and can insert into the lipid monolayers. The insertion ability of ApoH is stronger when a higher content of negatively charged lipids is present in the membrane. The acidic-pH and low-ionic-strength conditions will also enhance ApoH insertion, but these factors may not have much influence on the final insertion ability of ApoH, suggesting that, in the mechanism of ApoH insertion, not only electrostatic forces, but also hydrophobic interactions, are evidently involved. Modification by heat inactivation and reduction/alkylation does not change the critical insertion pressure (πc) of ApoH, suggesting a stable domain, maybe a linear sequence motif, but not the native three-dimensional structure of ApoH, is responsible for its insertion. The extent to which insertion of ApoH into phospholipid membranes may facilitate the ‘immune cleaning ’ of plasma liposomes is discussed.

scholarly journals Steered Molecular Dynamics of Lipid Membrane Indentation by Carbon and Silicon-Carbide Nanotubes—The Impact of Indenting Angle Uncertainty

Sensors ◽  
2021 ◽  
Vol 21 (21) ◽  
pp. 7011
Author(s):  
Przemysław Raczyński ◽  
Krzysztof Górny ◽  
Piotr Bełdowski ◽  
Steven Yuvan ◽  
Beata Marciniak ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Silicon Carbide ◽  
Molecular Dynamics Simulations ◽  
Lipid Membrane ◽  
Biological Membranes ◽  
Steered Molecular Dynamics ◽  
Phospholipid Membranes ◽  
Silicon Carbide Nanotubes ◽  
Dynamics Simulations ◽  
The Impact

Due to the semi-liquid nature and uneven morphologies of biological membranes, indentation may occur in a range of non-ideal conditions. These conditions are relatively unstudied and may alter the physical characteristics of the process. One of the basic challenges in the construction of nanoindenters is to appropriately align the nanotube tip and approach the membrane at a perpendicular angle. To investigate the impact of deviations from this ideal, we performed non-equilibrium steered molecular dynamics simulations of the indentation of phospholipid membranes by homogeneous CNT and non-homogeneous SiCNT indenters. We used various angles, rates, and modes of indentation, and the withdrawal of the relative indenter out of the membrane in corresponding conditions was simulated.

Self-assembly of artificial sweetener aspartame adversely affects phospholipid membranes: plausible reason for its deleterious effects

2021 ◽  
Vol 57 (81) ◽  
pp. 10532-10535
Author(s):  
Sourav Nandi ◽  
Souvik Layek ◽  
Pratyush Kiran Nandi ◽  
Nanigopal Bera ◽  
Ritwik Hazra ◽  
...  
Keyword(s):  
Self Assembly ◽  
Lipid Membrane ◽  
Phospholipid Membranes ◽  
Artificial Sweetener ◽  
Plausible Reason

Cytotoxic fibrillar aggregates of the artificial sweetener aspartame (ASP) disorganize a DMPC lipid membrane and reduce the membrane's intrinsic rigidity.

scholarly journals The effect of anaesthetics on the properties of a lipid membrane in the biologically relevant phase: a computer simulation study

2015 ◽  
Vol 17 (22) ◽  
pp. 14750-14760 ◽  
Author(s):  
Balázs Fábián ◽  
Mária Darvas ◽  
Sylvain Picaud ◽  
Marcello Sega ◽  
Pál Jedlovszky
Keyword(s):  
Computer Simulation ◽  
Simulation Study ◽  
High Pressures ◽  
Lipid Membrane ◽  
General Anaesthetic ◽  
Phospholipid Membranes ◽  
Computer Simulation Study ◽  
Biologically Relevant

Phospholipid membranes containing four different general anaesthetic molecules are simulated in the biologically relevant Lα phase at atmospheric and high pressures.

Chapter 2b: The molecular antigenic structure of the TBEV

2020 ◽  
Keyword(s):  
Conformational Changes ◽  
Neutralizing Antibodies ◽  
Lipid Membrane ◽  
Cell Entry ◽  
Antigenic Structure ◽  
E Proteins ◽  
Amino Acid Sequence Level ◽  
Endosomal Membrane ◽  
E Protein ◽  
Golgi Network

TBEV-particles are assembled in an immature, noninfectious form in the endoplasmic reticulum by the envelopment of the viral core (containing the viral RNA) by a lipid membrane associated with two viral proteins, prM and E. Immature particles are transported through the cellular exocytic pathway and conformational changes induced by acidic pH in the trans-Golgi network allow the proteolytic cleavage of prM by furin, a cellular protease, resulting in the release of mature and infectious TBE-virions. The E protein controls cell entry by mediating attachment to as yet ill-defined receptors as well as by low-pH-triggered fusion of the viral and endosomal membrane after uptake by receptor-mediated endocytosis. Because of its key functions in cell entry, the E protein is the primary target of virus neutralizing antibodies, which inhibit these functions by different mechanisms. Although all flavivirus E proteins have a similar overall structure, divergence at the amino acid sequence level is up to 60 percent (e.g. between TBE and dengue viruses), and therefore cross-neutralization as well as (some degree of) cross-protection are limited to relatively closely related flaviviruses, such as those constituting the tick-borne encephalitis serocomplex.

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