Self-assembly of artificial sweetener aspartame adversely affects phospholipid membranes: plausible reason for its deleterious effects

2021 ◽  
Vol 57 (81) ◽  
pp. 10532-10535
Author(s):  
Sourav Nandi ◽  
Souvik Layek ◽  
Pratyush Kiran Nandi ◽  
Nanigopal Bera ◽  
Ritwik Hazra ◽  
...  
Keyword(s):  
Self Assembly ◽  
Lipid Membrane ◽  
Phospholipid Membranes ◽  
Artificial Sweetener ◽  
Plausible Reason

Cytotoxic fibrillar aggregates of the artificial sweetener aspartame (ASP) disorganize a DMPC lipid membrane and reduce the membrane's intrinsic rigidity.

scholarly journals Electrochemical Properties of Lipid Membranes Self-Assembled from Bicelles

Membranes ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 11
Author(s):  
Damian Dziubak ◽  
Kamil Strzelak ◽  
Slawomir Sek
Keyword(s):  
Electrochemical Properties ◽  
Self Assembly ◽  
Lipid Membranes ◽  
Lipid Membrane ◽  
Membrane Resistance ◽  
Electrochemical Characteristics ◽  
Freeze Thaw ◽  
Lipid Films ◽  
Supported Lipid Membranes

Supported lipid membranes are widely used platforms which serve as simplified models of cell membranes. Among numerous methods used for preparation of planar lipid films, self-assembly of bicelles appears to be promising strategy. Therefore, in this paper we have examined the mechanism of formation and the electrochemical properties of lipid films deposited onto thioglucose-modified gold electrodes from bicellar mixtures. It was found that adsorption of the bicelles occurs by replacement of interfacial water and it leads to formation of a double bilayer structure on the electrode surface. The resulting lipid assembly contains numerous defects and pinholes which affect the permeability of the membrane for ions and water. Significant improvement in morphology and electrochemical characteristics is achieved upon freeze–thaw treatment of the deposited membrane. The lipid assembly is rearranged to single bilayer configuration with locally occurring patches of the second bilayer, and the number of pinholes is substantially decreased. Electrochemical characterization of the lipid membrane after freeze–thaw treatment demonstrated that its permeability for ions and water is significantly reduced, which was manifested by the relatively high value of the membrane resistance.

Self-Healing Bilayer Lipid Membranes Formed Over Synthetic Substrates

2008 ◽  
Author(s):  
M. Austin Creasy ◽  
Donald J. Leo
Keyword(s):  
Self Assembly ◽  
Lipid Membranes ◽  
Lipid Membrane ◽  
Bilayer Lipid Membrane ◽  
Unique Property ◽  
Bilayer Lipid Membranes ◽  
Self Healing ◽  
Electrical Field ◽  
Bilayer Lipid ◽  
Recent Experimental Study

Biological systems demonstrate autonomous healing of damage and are an inspiration for developing self-healing materials. Our recent experimental study has demonstrated that a bilayer lipid membrane (BLM), also called a black lipid membrane, has the ability to self-heal after mechanical failure. These molecules have a unique property that they spontaneously self assembly into organized structures in an aqueous medium. The BLM forms an impervious barrier to ions and fluid between two volumes and strength of the barrier is dependent on the pressure and electrical field applied to the membrane. A BLM formed over an aperture on a silicon substrate is shown to self-heal for 5 pressurization failure cycles.

Self-assembly of monolayered lipid membranes for surface-coating of a nanoconfined Bombyx mori silk fibroin film

RSC Advances ◽  
2015 ◽  
Vol 5 (81) ◽  
pp. 65684-65689 ◽  
Author(s):  
Fan Xu ◽  
Meimei Bao ◽  
Longfei Rui ◽  
Jiaojiao Liu ◽  
Jingliang Li ◽  
...  
Keyword(s):  
Bombyx Mori ◽  
Silk Fibroin ◽  
Self Assembly ◽  
Lipid Membranes ◽  
Surface Coating ◽  
Lipid Membrane ◽  
Coating Film ◽  
Silk Fibroin Film ◽  
Bombyx Mori Silk ◽  
Self Assembled

A self-assembled lipid membrane provides a smooth, hydrophilic and biocompatible surface coating film for materials.

Biomembrane induced in situ self-assembly of peptide with enhanced antimicrobial activity

2020 ◽  
Vol 8 (7) ◽  
pp. 2031-2039 ◽  
Author(s):  
Zhiwei Shen ◽  
Zhen Guo ◽  
Limin Zhou ◽  
Yujiao Wang ◽  
Jinjin Zhang ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Self Assembly ◽  
Lipid Membrane ◽  
Self Assembled

FF8 self-assembled into nanofibers on the negatively charged lipid membrane and induced rupture of the membrane.

scholarly journals Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jaroslaw Majewski ◽  
Emmalee M. Jones ◽  
Crystal M. Vander Zanden ◽  
Jacek Biernat ◽  
Eckhard Mandelkow ◽  
...  
Keyword(s):  
Tau Protein ◽  
Self Assembly ◽  
Lipid Membrane ◽  
Intrinsically Disordered

scholarly journals The insertion of human apolipoprotein H into phospholipid membranes: a monolayer study

1998 ◽  
Vol 335 (2) ◽  
pp. 225-232 ◽  
Author(s):  
Shao-Xiong WANG ◽  
Guo-ping CAI ◽  
Sen-fang SUI
Keyword(s):  
Lipid Membrane ◽  
Hydrophobic Interactions ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Heat Inactivation ◽  
Sequence Motif ◽  
Phospholipid Membranes ◽  
Human Apolipoprotein ◽  
Stable Domain ◽  
Apolipoprotein H

Apolipoprotein H (ApoH) is a plasma glycoprotein isolated from human serum. The interactions of ApoH with lipid membrane were reported to be essential for its physiological and pathogenic roles. In this paper we studied the ability of ApoH to insert into phospholipid membranes using the monolayer approach. The results show that ApoH is surface active and can insert into the lipid monolayers. The insertion ability of ApoH is stronger when a higher content of negatively charged lipids is present in the membrane. The acidic-pH and low-ionic-strength conditions will also enhance ApoH insertion, but these factors may not have much influence on the final insertion ability of ApoH, suggesting that, in the mechanism of ApoH insertion, not only electrostatic forces, but also hydrophobic interactions, are evidently involved. Modification by heat inactivation and reduction/alkylation does not change the critical insertion pressure (πc) of ApoH, suggesting a stable domain, maybe a linear sequence motif, but not the native three-dimensional structure of ApoH, is responsible for its insertion. The extent to which insertion of ApoH into phospholipid membranes may facilitate the ‘immune cleaning ’ of plasma liposomes is discussed.

scholarly journals Effect of Self-Assembly of Fullerene Nano-Particles on Lipid Membrane

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77436 ◽  
Author(s):  
Saiqun Zhang ◽  
Yuguang Mu ◽  
John Z. H. Zhang ◽  
Weixin Xu
Keyword(s):  
Self Assembly ◽  
Lipid Membrane ◽  
Nano Particles
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