Phase separations in phospholipid membranes

Biochemistry ◽  
1975 ◽  
Vol 14 (4) ◽  
pp. 847-854 ◽  
Author(s):  
Stephen H. W. Wu ◽  
Harden M. McConnell
Keyword(s):  
Phospholipid Membranes ◽  
Phase Separations

Configurable lipid membrane gradients quantify diffusion, phase separations and binding densities

Soft Matter ◽  
2015 ◽  
Vol 11 (42) ◽  
pp. 8217-8220 ◽  
Author(s):  
Katherine N. Liu ◽  
Chen-min S. Hung ◽  
Michael A. Swift ◽  
Kristen A. Muñoz ◽  
Jose L. Cortez ◽  
...  
Keyword(s):  
Lipid Membrane ◽  
Phospholipid Membranes ◽  
Phase Separations ◽  
Diffusion Phase

Tunable collisions between spreading phospholipid membranes form functional gradients.

Association of the polioviral RNA polymerase complex with phospholipid membranes.

1976 ◽  
Vol 19 (2) ◽  
pp. 457-466 ◽  
Author(s):  
B E Butterworth ◽  
E J Shimshick ◽  
F H Yin
Keyword(s):  
Rna Polymerase ◽  
Phospholipid Membranes ◽  
Polymerase Complex

scholarly journals Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2118
Author(s):  
Yusuke Hosoya ◽  
Junko Ohkanda
Keyword(s):  
Drug Targets ◽  
Intrinsically Disordered Proteins ◽  
Dynamic Control ◽  
Disordered Proteins ◽  
Biological Processes ◽  
Phase Separations ◽  
Cellular Processes ◽  
Intrinsically Disordered ◽  
New Drug ◽  
Liquid Phase Separations

Intrinsically disordered proteins (IDPs) are critical players in the dynamic control of diverse cellular processes, and provide potential new drug targets because their dysregulation is closely related to many diseases. This review focuses on several medicinal studies that have identified low-molecular-weight inhibitors of IDPs. In addition, clinically relevant liquid–liquid phase separations—which critically involve both intermolecular interactions between IDPs and their posttranslational modification—are analyzed to understand the potential of IDPs as new drug targets.

scholarly journals DEAD-box helicases modulate dicing body formation in Arabidopsis

2021 ◽  
Vol 7 (18) ◽  
pp. eabc6266
Author(s):  
Qi Li ◽  
Ningkun Liu ◽  
Qing Liu ◽  
Xingguo Zheng ◽  
Lu Lu ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Turnip Mosaic Virus ◽  
Liquid Droplets ◽  
Phase Separations ◽  
Body Formation ◽  
Cellular Processes ◽  
Dead Box ◽  
Body Components ◽  
Liquid Phase Separations ◽  
Spatiotemporal Control

Eukaryotic cells contain numerous membraneless organelles that are made from liquid droplets of proteins and nucleic acids and that provide spatiotemporal control of various cellular processes. However, the molecular mechanisms underlying the formation and rapid stress-induced alterations of these organelles are relatively uncharacterized. Here, we investigated the roles of DEAD-box helicases in the formation and alteration of membraneless nuclear dicing bodies (D-bodies) in Arabidopsis thaliana. We uncovered that RNA helicase 6 (RH6), RH8, and RH12 are previously unidentified D-body components. These helicases interact with and promote the phase separation of SERRATE, a key component of D-bodies, and drive the formation of D-bodies through liquid-liquid phase separations (LLPSs). The accumulation of these helicases in the nuclei decreases upon Turnip mosaic virus infections, which couples with the decrease of D-bodies. Our results thus reveal the key roles of RH6, RH8, and RH12 in modulating D-body formation via LLPSs.

Cationic specificity of double-layer phospholipid membranes modified with macrocyclic polyethers

1979 ◽  
Vol 15 (2) ◽  
pp. 212-213
Author(s):  
U. Z. Mirkhodzhaev ◽  
P. B. Usmanov ◽  
A. K. Tashmukhamedova
Keyword(s):  
Double Layer ◽  
Phospholipid Membranes ◽  
Macrocyclic Polyethers ◽  
Cationic Specificity
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