Guanidine modified polyethyleneimine-g-polyethylene glycol nanocarriers for long interfering RNA (liRNA) based advanced anticancer therapy

2015 ◽  
Vol 3 (2) ◽  
pp. 207-216 ◽  
Author(s):  
S. Sajeesh ◽  
Jeong Yong Choe ◽  
Tae Yeon Lee ◽  
Dong-ki Lee
Keyword(s):  
Polyethylene Glycol ◽  
Anticancer Therapy ◽  
Interfering Rna

Long interfering RNA mediated advanced anticancer therapy.

scholarly journals Combination Treatment with PPARγLigand and Its Specific Inhibitor GW9662 Downregulates BIS and 14-3-3 Gamma, Inhibiting Stem-Like Properties in Glioblastoma Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Chang-Nim Im
Keyword(s):  
Cellular Differentiation ◽  
Therapeutic Strategy ◽  
Specific Inhibitor ◽  
Anticancer Therapy ◽  
Parp Cleavage ◽  
Sirna Transfection ◽  
Poor Survival ◽  
Combined Administration ◽  
Differentiation And Proliferation ◽  
Interfering Rna

PPARγis a nuclear receptor that regulates differentiation and proliferation and is highly expressed in many cancer cells. Its synthetic ligands, such as rosiglitazone and ciglitazone, and its inhibitor GW9662, were shown to induce cellular differentiation, inhibit proliferation, and lead to apoptosis. Glioblastoma is a common brain tumor with poor survival prospects. Recently, glioblastoma stem cells (GSCs) have been examined as a potential target for anticancer therapy; however, little is known about the combined effect of various agents on GSCs. In this study, we found that cotreatment with PPARγligands and GW9662 inhibited stem-like properties in GSC-like spheres, which significantly express SOX2. In addition, this treatment decreased the activation of STAT3 and AKT and decreased the amounts of 14-3-3 gamma and BIS proteins. Moreover, combined administration of small-interfering RNA (siRNA) transfection with PPARγligands induced downregulation of SOX2 and MMP2 activity together with inhibition of sphere-forming activity regardless of poly(ADP-ribose) polymerase (PARP) cleavage. Taken together, our findings suggest that a combination therapy using PPARγligands and its inhibitor could be a potential therapeutic strategy targeting GSCs.

scholarly journals Post-nano strategies for drug delivery: multistage porous silicon microvectors

2017 ◽  
Vol 5 (2) ◽  
pp. 207-219 ◽  
Author(s):  
Alessandro Venuta ◽  
Joy Wolfram ◽  
Haifa Shen ◽  
Mauro Ferrari
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Porous Silicon ◽  
Small Interfering Rna ◽  
Glycolic Acid ◽  
Interfering Rna

This review discusses several post-nano solutions for drug delivery based on porous silicon microparticles. DOPC, dioleoylphosphatidylcholine; PEG, polyethylene glycol; PLGA, poly(lactic-co-glycolic acid); siRNA, small interfering RNA.

scholarly journals Significance of the balance between intracellular glutathione and polyethylene glycol for successful release of small interfering RNA from gold nanoparticles

Nano Research ◽  
2015 ◽  
Vol 8 (10) ◽  
pp. 3281-3292 ◽  
Author(s):  
Mark McCully ◽  
Yulan Hernandez ◽  
João Conde ◽  
Pedro V. Baptista ◽  
Jesus M. de la Fuente ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Polyethylene Glycol ◽  
Small Interfering Rna ◽  
Intracellular Glutathione ◽  
Interfering Rna

scholarly journals Polyethylene glycol (PEG)-dendron phospholipids as innovative constructs for the preparation of super stealth liposomes for anticancer therapy

2015 ◽  
Vol 199 ◽  
pp. 106-113 ◽  
Author(s):  
Gianfranco Pasut ◽  
Donatella Paolino ◽  
Christian Celia ◽  
Anna Mero ◽  
Adrian Steve Joseph ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Anticancer Therapy ◽  
Stealth Liposomes

Anticancer Therapy by Tumor Vessel Infarction with Polyethylene Glycol Conjugated Retargeted Tissue Factor

2013 ◽  
Vol 56 (6) ◽  
pp. 2337-2347 ◽  
Author(s):  
Christian Schwöppe ◽  
Caroline Zerbst ◽  
Max Fröhlich ◽  
Christoph Schliemann ◽  
Torsten Kessler ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Tissue Factor ◽  
Anticancer Therapy ◽  
Tumor Vessel

A novel albumin nanocomplex containing both small interfering RNA and gold nanorods for synergetic anticancer therapy

Nanoscale ◽  
2015 ◽  
Vol 7 (20) ◽  
pp. 9229-9237 ◽  
Author(s):  
Jin-Ha Choi ◽  
Hai-Jin Hwang ◽  
Seung Won Shin ◽  
Jeong-Woo Choi ◽  
Soong Ho Um ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Small Interfering Rna ◽  
Anticancer Therapy ◽  
Interfering Rna

Immunocytochemical detection of hepatic carbohydrate metabolic enzymes: Improved resolution with polyethylene glycol embedding and visio-bond semithin sections

1992 ◽  
Vol 50 (1) ◽  
pp. 792-793
Author(s):  
Kuixiong Gao ◽  
Randal E. Morris ◽  
Bruce F. Giffin ◽  
Robert R. Cardell
Keyword(s):  
Polyethylene Glycol ◽  
Glycogen Phosphorylase ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Glycogen Synthase ◽  
Metabolic Enzymes ◽  
Silver Stain ◽  
Accurate Localization ◽  
Immunocytochemical Detection ◽  
Semithin Sections ◽  
Parenchymal Cells

Several enzymes are involved in the regulation of anabolic and catabolic pathways of carbohydrate metabolism in liver parenchymal cells. The lobular distribution of glycogen synthase (GS), phosphoenolpyruvate carboxykinase (PEPCK) and glycogen phosphorylase (GP) was studied by immunocytochemistry using cryosections of normal fed and fasted rat liver. Since sections of tissue embedded in polyethylene glycol (PEG) show good morphological preservation and increased detectability for immunocytochemical localization of antigenic sites, and semithin sections of Visio-Bond (VB) embedded tissue provide higher resolution of cellular structure, we applied these techniques and immunogold-silver stain (IGSS) for a more accurate localization of hepatic carbohydrate metabolic enzymes.

Directional observation on lipid of male nectary of Lindera megaphylla hemsl. by the rapid embedding method with polyethylene glycol (PEG)

1990 ◽  
Vol 48 (3) ◽  
pp. 718-719
Author(s):  
Dai Dalin ◽  
Guo Jianmin
Keyword(s):  
Electron Microscope ◽  
Polyethylene Glycol ◽  
Chemical Reaction ◽  
Traditional Method ◽  
Osmium Tetroxide ◽  
Unsaturated Lipid ◽  
Embedding Method ◽  
Long Period ◽  
New Methods

Lipid cytochemistry has not yet advanced far at the EM level. A major problem has been the loss of lipid during dehydration and embedding. Although the adoption of glutaraldehyde and osmium tetroxide accelerate the chemical reaction of lipid and osmium tetroxide can react on the double bouds of unsaturated lipid to from the osmium black, osmium tetroxide can be reduced in saturated lipid and subsequently some of unsaturated lipid are lost during dehydration. In order to reduce the loss of lipid by traditional method, some researchers adopted a few new methods, such as the change of embedding procedure and the adoption of new embedding media, to solve the problem. In a sense, these new methods are effective. They, however, usually require a long period of preparation. In this paper, we do research on the fiora nectary strucure of lauraceae by the rapid-embedding method wwith PEG under electron microscope and attempt to find a better method to solve the problem mentioned above.

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