scholarly journals Post-nano strategies for drug delivery: multistage porous silicon microvectors

2017 ◽  
Vol 5 (2) ◽  
pp. 207-219 ◽  
Author(s):  
Alessandro Venuta ◽  
Joy Wolfram ◽  
Haifa Shen ◽  
Mauro Ferrari
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Porous Silicon ◽  
Small Interfering Rna ◽  
Glycolic Acid ◽  
Interfering Rna

This review discusses several post-nano solutions for drug delivery based on porous silicon microparticles. DOPC, dioleoylphosphatidylcholine; PEG, polyethylene glycol; PLGA, poly(lactic-co-glycolic acid); siRNA, small interfering RNA.

scholarly journals Release of siRNA from Liposomes Induced by Curcumin

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Kazuyo Fujita ◽  
Yoshie Hiramatsu ◽  
Hideki Minematsu ◽  
Masaharu Somiya ◽  
Shun’ichi Kuroda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dose Response ◽  
Small Interfering Rna ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Experimental Conditions ◽  
Large Molecules ◽  
Maximal Induction ◽  
Interfering Rna ◽  
Bell Shaped Curve

Liposomes are a potential carrier of small interfering RNA (siRNA) for drug delivery systems (DDS). In this study, we searched for a molecule capable of controlling the release of siRNA from a certain type of liposomes and found that curcumin could induce the release of siRNA from the liposomes encapsulating siRNA within 30 min. However, the release of siRNA from the liposomes by curcumin showed a unique dose-response (i.e., bell-shaped curve) with a maximal induction at around 60 μg/ml of curcumin. Liposomal lipid compositions and temperatures influenced the efficiency in the release of siRNA induced by curcumin. About 10% of curcumin at a 60 μg/ml dose was incorporated into the liposomes within 30 min under our experimental conditions. Our results suggest a possibility that curcumin is useful in controlling the permeability of liposomes carrying large molecules like siRNA.

scholarly journals Natural Polysaccharides for siRNA Delivery: Nanocarriers Based on Chitosan, Hyaluronic Acid, and Their Derivatives

Molecules ◽  
2019 ◽  
Vol 24 (14) ◽  
pp. 2570 ◽  
Author(s):  
Inés Serrano-Sevilla ◽  
Álvaro Artiga ◽  
Scott G. Mitchell ◽  
Laura De Matteis ◽  
Jesús M. de la Fuente
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Small Interfering Rna ◽  
Drug Delivery Systems ◽  
Sirna Delivery ◽  
Delivery Systems ◽  
Low Toxicity ◽  
Interfering Rna

Natural polysaccharides are frequently used in the design of drug delivery systems due to their biocompatibility, biodegradability, and low toxicity. Moreover, they are diverse in structure, size, and charge, and their chemical functional groups can be easily modified to match the needs of the final application and mode of administration. This review focuses on polysaccharidic nanocarriers based on chitosan and hyaluronic acid for small interfering RNA (siRNA) delivery, which are highly positively and negatively charged, respectively. The key properties, strengths, and drawbacks of each polysaccharide are discussed. In addition, their use as efficient nanodelivery systems for gene silencing applications is put into context using the most recent examples from the literature. The latest advances in this field illustrate effectively how chitosan and hyaluronic acid can be modified or associated with other molecules in order to overcome their limitations to produce optimized siRNA delivery systems with promising in vitro and in vivo results.

Small interfering RNA delivery by polyethylenimine-functionalised porous silicon nanoparticles

2015 ◽  
Vol 3 (12) ◽  
pp. 1555-1565 ◽  
Author(s):  
M. Hasanzadeh Kafshgari ◽  
M. Alnakhli ◽  
B. Delalat ◽  
S. Apostolou ◽  
F. J. Harding ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Protein Expression ◽  
Resistance Gene ◽  
Small Interfering Rna ◽  
Silicon Nanoparticles ◽  
Chemotherapy Resistance ◽  
Glioblastoma Cells ◽  
Mesoporous Silicon ◽  
Porous Silicon Nanoparticles ◽  
Interfering Rna

Polyethyleneimine-coated mesoporous silicon nanoparticles efficiently deliver siRNA in glioblastoma cells, subsequently reducing the protein expression of a chemotherapy resistance gene by 70% within 72 hours.

scholarly journals Significance of the balance between intracellular glutathione and polyethylene glycol for successful release of small interfering RNA from gold nanoparticles

Nano Research ◽  
2015 ◽  
Vol 8 (10) ◽  
pp. 3281-3292 ◽  
Author(s):  
Mark McCully ◽  
Yulan Hernandez ◽  
João Conde ◽  
Pedro V. Baptista ◽  
Jesus M. de la Fuente ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Polyethylene Glycol ◽  
Small Interfering Rna ◽  
Intracellular Glutathione ◽  
Interfering Rna
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