Anticancer Therapy by Tumor Vessel Infarction with Polyethylene Glycol Conjugated Retargeted Tissue Factor

2013 ◽  
Vol 56 (6) ◽  
pp. 2337-2347 ◽  
Author(s):  
Christian Schwöppe ◽  
Caroline Zerbst ◽  
Max Fröhlich ◽  
Christoph Schliemann ◽  
Torsten Kessler ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Tissue Factor ◽  
Anticancer Therapy ◽  
Tumor Vessel

scholarly journals NG2 proteoglycan as a pericyte target for anticancer therapy by tumor vessel infarction with retargeted tissue factor

Oncotarget ◽  
2016 ◽  
Vol 7 (6) ◽  
pp. 6774-6789 ◽  
Author(s):  
Caroline Brand ◽  
Christoph Schliemann ◽  
Janine Ring ◽  
Torsten Kessler ◽  
Sebastian Bäumer ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Anticancer Therapy ◽  
Tumor Vessel ◽  
Ng2 Proteoglycan

Low-Energy Ultrasound Treatment Improves Regional Tumor Vessel Infarction by Retargeted Tissue Factor

2015 ◽  
Vol 34 (7) ◽  
pp. 1227-1236 ◽  
Author(s):  
Caroline Brand ◽  
Stefanie Dencks ◽  
Georg Schmitz ◽  
Mareike Mühlmeister ◽  
Jörg Stypmann ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Low Energy ◽  
Ultrasound Treatment ◽  
Tumor Vessel

scholarly journals Polyethylene glycol (PEG)-dendron phospholipids as innovative constructs for the preparation of super stealth liposomes for anticancer therapy

2015 ◽  
Vol 199 ◽  
pp. 106-113 ◽  
Author(s):  
Gianfranco Pasut ◽  
Donatella Paolino ◽  
Christian Celia ◽  
Anna Mero ◽  
Adrian Steve Joseph ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Anticancer Therapy ◽  
Stealth Liposomes

Non-invasive monitoring of tumor-vessel infarction by retargeted truncated tissue factor tTF–NGR using multi-modal imaging

Angiogenesis ◽  
2013 ◽  
Vol 17 (1) ◽  
pp. 235-246 ◽  
Author(s):  
Thorsten Persigehl ◽  
Janine Ring ◽  
Christoph Bremer ◽  
Walter Heindel ◽  
Richard Holtmeier ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Invasive Monitoring ◽  
Tumor Vessel ◽  
Non Invasive

scholarly journals Multiparametric Magnetic Resonance Imaging for Immediate Target Hit Assessment of CD13—Targeted Tissue Factor tTF-NGR in Advanced Malignant Disease

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 5880
Author(s):  
Mirjam Gerwing ◽  
Tobias Krähling ◽  
Christoph Schliemann ◽  
Saliha Harrach ◽  
Christian Schwöppe ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Malignant Disease ◽  
Volume Fraction ◽  
Multiparametric Mri ◽  
Tumor Perfusion ◽  
Tumor Vessel ◽  
Early Assessment ◽  
Imaging Protocol ◽  
Therapy Initiation ◽  
Adc Values

Early assessment of target hit in anti-cancer therapies is a major task in oncologic imaging. In this study, immediate target hit and effectiveness of CD13-targeted tissue factor tTF-NGR in patients with advanced malignant disease enrolled in a phase I trial was assessed using a multiparametric MRI protocol. Seventeen patients with advanced solid malignancies were enrolled in the trial and received tTF-NGR for at least one cycle of five daily infusions. Tumor target lesions were imaged with multiparametric MRI before therapy initiation, five hours after the first infusion and after five days. The imaging protocol comprised ADC, calculated from DWI, and DCE imaging and vascular volume fraction (VVF) assessment. DCE and VVF values decreased within 5 h after therapy initiation, indicating early target hit with a subsequent decrease in tumor perfusion due to selective tumor vessel occlusion and thrombosis induced by tTF-NGR. Simultaneously, ADC values increased at five hours after tTF-NGR administration. In four patients, treatment had to be stopped due to an increase in troponin T hs, with subsequent anticoagulation. In these patients, a reversed effect, with DCE and VVF values increasing and ADC values decreasing, was observed after anticoagulation. Changes in imaging parameters were independent of the mean vessel density determined by immunohistochemistry. By using a multiparametric imaging approach, changes in tumor perfusion after initiation of a tumor vessel occluding therapy can be evaluated as early as five hours after therapy initiation, enabling early assessment of target hit.

Guanidine modified polyethyleneimine-g-polyethylene glycol nanocarriers for long interfering RNA (liRNA) based advanced anticancer therapy

2015 ◽  
Vol 3 (2) ◽  
pp. 207-216 ◽  
Author(s):  
S. Sajeesh ◽  
Jeong Yong Choe ◽  
Tae Yeon Lee ◽  
Dong-ki Lee
Keyword(s):  
Polyethylene Glycol ◽  
Anticancer Therapy ◽  
Interfering Rna

Long interfering RNA mediated advanced anticancer therapy.

Unusual Benefits of Macromolecular Shielding by Polyethylene Glycol for Reactions at the Diffusional Limit:  The Case of Factor VIIai and Tissue Factor†

Biochemistry ◽  
2002 ◽  
Vol 41 (52) ◽  
pp. 15820-15825 ◽  
Author(s):  
Matthew Stone ◽  
Stephen B. Harvey ◽  
Walter Kisiel ◽  
Donald Foster ◽  
Gary L. Nelsestuen
Keyword(s):  
Polyethylene Glycol ◽  
Tissue Factor

Immunocytochemical detection of hepatic carbohydrate metabolic enzymes: Improved resolution with polyethylene glycol embedding and visio-bond semithin sections

1992 ◽  
Vol 50 (1) ◽  
pp. 792-793
Author(s):  
Kuixiong Gao ◽  
Randal E. Morris ◽  
Bruce F. Giffin ◽  
Robert R. Cardell
Keyword(s):  
Polyethylene Glycol ◽  
Glycogen Phosphorylase ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Glycogen Synthase ◽  
Metabolic Enzymes ◽  
Silver Stain ◽  
Accurate Localization ◽  
Immunocytochemical Detection ◽  
Semithin Sections ◽  
Parenchymal Cells

Several enzymes are involved in the regulation of anabolic and catabolic pathways of carbohydrate metabolism in liver parenchymal cells. The lobular distribution of glycogen synthase (GS), phosphoenolpyruvate carboxykinase (PEPCK) and glycogen phosphorylase (GP) was studied by immunocytochemistry using cryosections of normal fed and fasted rat liver. Since sections of tissue embedded in polyethylene glycol (PEG) show good morphological preservation and increased detectability for immunocytochemical localization of antigenic sites, and semithin sections of Visio-Bond (VB) embedded tissue provide higher resolution of cellular structure, we applied these techniques and immunogold-silver stain (IGSS) for a more accurate localization of hepatic carbohydrate metabolic enzymes.

Directional observation on lipid of male nectary of Lindera megaphylla hemsl. by the rapid embedding method with polyethylene glycol (PEG)

1990 ◽  
Vol 48 (3) ◽  
pp. 718-719
Author(s):  
Dai Dalin ◽  
Guo Jianmin
Keyword(s):  
Electron Microscope ◽  
Polyethylene Glycol ◽  
Chemical Reaction ◽  
Traditional Method ◽  
Osmium Tetroxide ◽  
Unsaturated Lipid ◽  
Embedding Method ◽  
Long Period ◽  
New Methods

Lipid cytochemistry has not yet advanced far at the EM level. A major problem has been the loss of lipid during dehydration and embedding. Although the adoption of glutaraldehyde and osmium tetroxide accelerate the chemical reaction of lipid and osmium tetroxide can react on the double bouds of unsaturated lipid to from the osmium black, osmium tetroxide can be reduced in saturated lipid and subsequently some of unsaturated lipid are lost during dehydration. In order to reduce the loss of lipid by traditional method, some researchers adopted a few new methods, such as the change of embedding procedure and the adoption of new embedding media, to solve the problem. In a sense, these new methods are effective. They, however, usually require a long period of preparation. In this paper, we do research on the fiora nectary strucure of lauraceae by the rapid-embedding method wwith PEG under electron microscope and attempt to find a better method to solve the problem mentioned above.

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