Temperature- and redox-responsive magnetic complex micelles for controlled drug release

2015 ◽  
Vol 3 (2) ◽  
pp. 260-269 ◽  
Author(s):  
Hui Zou ◽  
Weizhong Yuan
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Redox Responsive ◽  
Complex Micelles ◽  
Magnetic Complex

PCL-SS-PDMAEMA/Fe3O4 magnetic complex micelles can present dual temperature- and redox-responses, magnetism and magnetothermal properties.

Redox-responsive, core-crosslinked degradable micelles for controlled drug release

2016 ◽  
Vol 7 (41) ◽  
pp. 6330-6339 ◽  
Author(s):  
Yingchun Xia ◽  
Hua He ◽  
Xiangyu Liu ◽  
Ding Hu ◽  
Lichen Yin ◽  
...  
Keyword(s):  
Drug Release ◽  
Click Chemistry ◽  
Controlled Drug Release ◽  
Redox Responsive ◽  
One Step ◽  
Crosslinked Micelles

We developed novel redox-responsive, core-crosslinked micelles (CCLMs) via a simple, one-step click chemistry reaction.

Triple Redox Responsive Poly(Ethylene Glycol)-Polycaprolactone Polymeric Nanocarriers for Fine-Controlled Drug Release

2016 ◽  
Vol 17 (4) ◽  
pp. 1600295 ◽  
Author(s):  
Caiyan Zhao ◽  
Leihou Shao ◽  
Jianqing Lu ◽  
Chenying Zhao ◽  
Yujie Wei ◽  
...  
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Controlled Drug Release ◽  
Poly Ethylene Glycol ◽  
Polymeric Nanocarriers ◽  
Redox Responsive ◽  
Poly Ethylene

scholarly journals Pillar[5]arene pseudo[1]rotaxane-based redox-responsive supramolecular vesicles for controlled drug release

2019 ◽  
Vol 3 (7) ◽  
pp. 1427-1432 ◽  
Author(s):  
Ya-Han Cui ◽  
Rong Deng ◽  
Zheng Li ◽  
Xu-Sheng Du ◽  
Qiong Jia ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Drugs ◽  
Controlled Drug Release ◽  
Redox Responsive

Pillar[5]arene pseudo[1]rotaxane-based supramolecular vesicles loaded with anticancer drugs could deliver the payload to the targeted area of high GSH concentrations.

scholarly journals Actively Targeted and Redox Responsive Delivery of Anticancer Drug by Chitosan Nanoparticles

Pharmaceutics ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 26 ◽  
Author(s):  
Elisabetta Mazzotta ◽  
Selene De Benedittis ◽  
Antonio Qualtieri ◽  
Rita Muzzalupo
Keyword(s):  
Drug Release ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Water Solubility ◽  
Chitosan Nanoparticles ◽  
Controlled Drug Release ◽  
Dependent Manner ◽  
High Concentration ◽  
Redox Responsive

The clinical efficacy of methotrexate (MTX) is limited by its poor water solubility, its low bioavailability, and the development of resistance in cancer cells. Herein, we developed novel folate redox-responsive chitosan (FTC) nanoparticles for intracellular MTX delivery. l-Cysteine and folic acid molecules were selected to be covalently linked to chitosan in order to confer it redox responsiveness and active targeting of folate receptors (FRs). NPs based on these novel polymers could possess tumor specificity and a controlled drug release due to the overexpression of FRs and high concentration of reductive agents in the microenvironment of cancer cells. Nanoparticles (NPs) were prepared using an ionotropic gelation technique and characterized in terms of size, morphology, and loading capacity. In vitro drug release profiles exhibited a glutathione (GSH) dependence. In the normal physiological environment, NPs maintained good stability, whereas, in a reducing environment similar to tumor cells, the encapsulated MTX was promptly released. The anticancer activity of MTX-loaded FTC-NPs was also studied by incubating HeLa cells with formulations for various time and concentration intervals. A significant reduction in viability was observed in a dose- and time-dependent manner. In particular, FTC-NPs showed a better inhibition effect on HeLa cancer cell proliferation compared to non-target chitosan-based NPs used as control. The selective cellular uptake of FTC-NPs via FRs was evaluated and confirmed by fluorescence microscopy. Overall, the designed NPs provide an attractive strategy and potential platform for efficient intracellular anticancer drug delivery.

Fabrication of Complex Micelles with Tunable Shell for Application in Controlled Drug Release

2009 ◽  
Vol 9 (12) ◽  
pp. 1185-1193 ◽  
Author(s):  
Chenglin Wu ◽  
Rujiang Ma ◽  
Huan He ◽  
Lizhi Zhao ◽  
Hongjun Gao ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Complex Micelles

Fabrication of biofunctional complex micelles with tunable structure for application in controlled drug release

2014 ◽  
Vol 292 (7) ◽  
pp. 1675-1683 ◽  
Author(s):  
Lizhi Zhao ◽  
Chenglin Wu ◽  
Fang Wang ◽  
Anguo Ying ◽  
Chendiao Xu ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Tunable Structure ◽  
Complex Micelles

scholarly journals Degradable redox-responsive disulfide-based nanogel drug carriers via dithiol oxidation polymerization

2019 ◽  
Vol 7 (2) ◽  
pp. 607-617 ◽  
Author(s):  
Sussana A. Elkassih ◽  
Petra Kos ◽  
Hu Xiong ◽  
Daniel J. Siegwart
Keyword(s):  
Drug Release ◽  
Small Molecules ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Stimuli Responsive ◽  
Redox Responsive

Stimuli-responsive nanogels degrade to small molecules in reducing environments to mediate controlled drug release.

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