scholarly journals Pillar[5]arene pseudo[1]rotaxane-based redox-responsive supramolecular vesicles for controlled drug release

2019 ◽  
Vol 3 (7) ◽  
pp. 1427-1432 ◽  
Author(s):  
Ya-Han Cui ◽  
Rong Deng ◽  
Zheng Li ◽  
Xu-Sheng Du ◽  
Qiong Jia ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Drugs ◽  
Controlled Drug Release ◽  
Redox Responsive

Pillar[5]arene pseudo[1]rotaxane-based supramolecular vesicles loaded with anticancer drugs could deliver the payload to the targeted area of high GSH concentrations.

Redox-responsive, core-crosslinked degradable micelles for controlled drug release

2016 ◽  
Vol 7 (41) ◽  
pp. 6330-6339 ◽  
Author(s):  
Yingchun Xia ◽  
Hua He ◽  
Xiangyu Liu ◽  
Ding Hu ◽  
Lichen Yin ◽  
...  
Keyword(s):  
Drug Release ◽  
Click Chemistry ◽  
Controlled Drug Release ◽  
Redox Responsive ◽  
One Step ◽  
Crosslinked Micelles

We developed novel redox-responsive, core-crosslinked micelles (CCLMs) via a simple, one-step click chemistry reaction.

Triple Redox Responsive Poly(Ethylene Glycol)-Polycaprolactone Polymeric Nanocarriers for Fine-Controlled Drug Release

2016 ◽  
Vol 17 (4) ◽  
pp. 1600295 ◽  
Author(s):  
Caiyan Zhao ◽  
Leihou Shao ◽  
Jianqing Lu ◽  
Chenying Zhao ◽  
Yujie Wei ◽  
...  
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Controlled Drug Release ◽  
Poly Ethylene Glycol ◽  
Polymeric Nanocarriers ◽  
Redox Responsive ◽  
Poly Ethylene

scholarly journals Targeted, Monitored, and Controlled Chemotherapy: A Multimodal Nanotechnology-Based Approach against Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Ali Shakeri-Zadeh ◽  
Samideh Khoei ◽  
Sepideh Khoee ◽  
Ali Mohammad Sharifi ◽  
Mohammad-Bagher Shiran
Keyword(s):  
Drug Release ◽  
Anticancer Drugs ◽  
Polymeric Nanoparticles ◽  
Control Release ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Chemotherapeutic Agents ◽  
Drug Uptake ◽  
Cancerous Cell ◽  
Cancer Tumor

We review innovative methods for treatment of cancer tumor on the basis of nanotechnology and physics to target, monitor and control release of chemotherapeutic agents. Chemotherapy is one of the main methods of treatment for cancer and plays a vital role in clinical practice, but side effects of anticancer drugs are still critical problems. Magnetic nanoparticles can be applied as an effective drug carriers and contrast agents for magnetic resonance imaging (MRI). Since certain nanoparticles have magnetic properties, they can be trapped in tumor during blood circulation by an external magnetic field. Also, polymeric nanoparticles are great candidates to encapsulate anticancer drugs and to control the release profile of drugs in biologic media. We suggest the construction of drug-loaded polymer-coated magnetic (DPM) nanoplatform with the potential for being utilized in medical imaging as well as having controlled drug release properties. Nanoplatform distribution can be monitored by MRI and with clever combination of ultrasound physics and suggested DPM nanoplatform, it would be feasible to increase the rate of drug release (in situ) and drug uptake by cancerous cell. To optimize the level of drug uptake by cancerous cell, the selection of ultrasound frequency and intensity is essential. The development of suggested method could be a new approach against cancer tumor.

scholarly journals Actively Targeted and Redox Responsive Delivery of Anticancer Drug by Chitosan Nanoparticles

Pharmaceutics ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 26 ◽  
Author(s):  
Elisabetta Mazzotta ◽  
Selene De Benedittis ◽  
Antonio Qualtieri ◽  
Rita Muzzalupo
Keyword(s):  
Drug Release ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Water Solubility ◽  
Chitosan Nanoparticles ◽  
Controlled Drug Release ◽  
Dependent Manner ◽  
High Concentration ◽  
Redox Responsive

The clinical efficacy of methotrexate (MTX) is limited by its poor water solubility, its low bioavailability, and the development of resistance in cancer cells. Herein, we developed novel folate redox-responsive chitosan (FTC) nanoparticles for intracellular MTX delivery. l-Cysteine and folic acid molecules were selected to be covalently linked to chitosan in order to confer it redox responsiveness and active targeting of folate receptors (FRs). NPs based on these novel polymers could possess tumor specificity and a controlled drug release due to the overexpression of FRs and high concentration of reductive agents in the microenvironment of cancer cells. Nanoparticles (NPs) were prepared using an ionotropic gelation technique and characterized in terms of size, morphology, and loading capacity. In vitro drug release profiles exhibited a glutathione (GSH) dependence. In the normal physiological environment, NPs maintained good stability, whereas, in a reducing environment similar to tumor cells, the encapsulated MTX was promptly released. The anticancer activity of MTX-loaded FTC-NPs was also studied by incubating HeLa cells with formulations for various time and concentration intervals. A significant reduction in viability was observed in a dose- and time-dependent manner. In particular, FTC-NPs showed a better inhibition effect on HeLa cancer cell proliferation compared to non-target chitosan-based NPs used as control. The selective cellular uptake of FTC-NPs via FRs was evaluated and confirmed by fluorescence microscopy. Overall, the designed NPs provide an attractive strategy and potential platform for efficient intracellular anticancer drug delivery.

Novel phthalocyanine-based micelles/PNIPAM composite hydrogels: spatially/temporally controlled drug release triggered by NIR laser irradiation

2020 ◽  
Vol 44 (21) ◽  
pp. 8705-8709
Author(s):  
Lu Li ◽  
Wancheng Zhao ◽  
Zheng Qu ◽  
Lei Shi ◽  
Shengnan Tan ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Laser Irradiation ◽  
Anticancer Drugs ◽  
Near Infrared ◽  
Biomedical Application ◽  
Controlled Drug Release ◽  
Nir Light ◽  
Responsive Hydrogels ◽  
Nir Laser

Near-infrared (NIR) light-responsive hydrogels hold significant potential for biomedical application, especially in the remote-controlled release of anticancer drugs.

scholarly journals Degradable redox-responsive disulfide-based nanogel drug carriers via dithiol oxidation polymerization

2019 ◽  
Vol 7 (2) ◽  
pp. 607-617 ◽  
Author(s):  
Sussana A. Elkassih ◽  
Petra Kos ◽  
Hu Xiong ◽  
Daniel J. Siegwart
Keyword(s):  
Drug Release ◽  
Small Molecules ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Stimuli Responsive ◽  
Redox Responsive

Stimuli-responsive nanogels degrade to small molecules in reducing environments to mediate controlled drug release.

Temperature- and redox-responsive magnetic complex micelles for controlled drug release

2015 ◽  
Vol 3 (2) ◽  
pp. 260-269 ◽  
Author(s):  
Hui Zou ◽  
Weizhong Yuan
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Redox Responsive ◽  
Complex Micelles ◽  
Magnetic Complex

PCL-SS-PDMAEMA/Fe3O4 magnetic complex micelles can present dual temperature- and redox-responses, magnetism and magnetothermal properties.

scholarly journals Reversibly crosslinked thermo- and redox-responsive nanogels for controlled drug release

2014 ◽  
Vol 5 (1) ◽  
pp. 77-88 ◽  
Author(s):  
Ji Liu ◽  
Christophe Detrembleur ◽  
Marie Hurtgen ◽  
Antoine Debuigne ◽  
Marie-Claire De Pauw-Gillet ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Redox Responsive
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