scholarly journals Degradable redox-responsive disulfide-based nanogel drug carriers via dithiol oxidation polymerization

2019 ◽  
Vol 7 (2) ◽  
pp. 607-617 ◽  
Author(s):  
Sussana A. Elkassih ◽  
Petra Kos ◽  
Hu Xiong ◽  
Daniel J. Siegwart
Keyword(s):  
Drug Release ◽  
Small Molecules ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Stimuli Responsive ◽  
Redox Responsive

Stimuli-responsive nanogels degrade to small molecules in reducing environments to mediate controlled drug release.

scholarly journals Combining Dextran Conjugates with Stimuli-Responsive and Folate-Targeting Activity: A New Class of Multifunctional Nanoparticles for Cancer Therapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1108
Author(s):  
Manuela Curcio ◽  
Alessandro Paolì ◽  
Giuseppe Cirillo ◽  
Sebastiano Di Pietro ◽  
Martina Forestiero ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Metastatic Cancer ◽  
Stimuli Responsive ◽  
Cancer Disease ◽  
New Class ◽  
Self Assembling ◽  
Redox Responsive ◽  
Potential Applicability ◽  
Mean Size

Nanoparticles with active-targeting and stimuli-responsive behavior are a promising class of engineered materials able to recognize the site of cancer disease, targeting the drug release and limiting side effects in the healthy organs. In this work, new dual pH/redox-responsive nanoparticles with affinity for folate receptors were prepared by the combination of two amphiphilic dextran (DEX) derivatives. DEXFA conjugate was obtained by covalent coupling of the polysaccharide with folic acid (FA), whereas DEXssPEGCOOH derived from a reductive amination step of DEX was followed by condensation with polyethylene glycol 600. After self-assembling, nanoparticles with a mean size of 50 nm, able to be destabilized in acidic pH and reducing media, were obtained. Doxorubicin was loaded during the self-assembling process, and the release experiments showed the ability of the proposed system to modulate the drug release in response to different pH and redox conditions. Finally, the viability and uptake experiments on healthy (MCF-10A) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a new drug vector in cancer therapy.

scholarly journals Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system

2016 ◽  
Vol 52 (69) ◽  
pp. 10525-10528 ◽  
Author(s):  
Saemi O. Poelma ◽  
Seung Soo Oh ◽  
Sameh Helmy ◽  
Abigail S. Knight ◽  
G. Leslie Burnett ◽  
...  
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Small Molecules ◽  
Cancer Cells ◽  
Controlled Drug Release ◽  
Micellar System ◽  
On Demand ◽  
System P

We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules.

Redox-responsive degradable honeycomb manganese oxide nanostructures as effective nanocarriers for intracellular glutathione-triggered drug release

2015 ◽  
Vol 51 (4) ◽  
pp. 776-779 ◽  
Author(s):  
Dinggeng He ◽  
Xiaoxiao He ◽  
Kemin Wang ◽  
Xue Yang ◽  
Xiaoxiao Yang ◽  
...  
Keyword(s):  
Drug Release ◽  
Manganese Oxide ◽  
Drug Carriers ◽  
New Class ◽  
Oxide Nanostructures ◽  
Redox Responsive ◽  
Intracellular Glutathione ◽  
Triggered Drug Release

Redox-responsive degradable honeycomb manganese oxide (hMnO2) nanostructures consisting of some lamellar MnO2 platelets were established as a new class of drug carriers for efficient intracellular GSH-triggered drug release.

Bioactive films of zein/magnetite magnetically stimuli-responsive for controlled drug release

2018 ◽  
Vol 458 ◽  
pp. 355-364 ◽  
Author(s):  
Tíffany Marín ◽  
Paula Montoya ◽  
Oscar Arnache ◽  
Rodolfo Pinal ◽  
Jorge Calderón
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Stimuli Responsive

Cap-free dual stimuli-responsive biodegradable nanocarrier for controlled drug release and chemo-photothermal therapy

2018 ◽  
Vol 6 (48) ◽  
pp. 8188-8195 ◽  
Author(s):  
Fang Wang ◽  
Zemin Wang ◽  
Yansheng Li ◽  
Liang Zhao ◽  
Yongqiang Wen ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Photothermal Therapy ◽  
Controlled Drug Release ◽  
Stimuli Responsive

The cap-free nanocarrier with fast biodegradability achieved controlled release and chemo-photothermal therapy in vitro.

Redox-responsive, core-crosslinked degradable micelles for controlled drug release

2016 ◽  
Vol 7 (41) ◽  
pp. 6330-6339 ◽  
Author(s):  
Yingchun Xia ◽  
Hua He ◽  
Xiangyu Liu ◽  
Ding Hu ◽  
Lichen Yin ◽  
...  
Keyword(s):  
Drug Release ◽  
Click Chemistry ◽  
Controlled Drug Release ◽  
Redox Responsive ◽  
One Step ◽  
Crosslinked Micelles

We developed novel redox-responsive, core-crosslinked micelles (CCLMs) via a simple, one-step click chemistry reaction.

Triple Redox Responsive Poly(Ethylene Glycol)-Polycaprolactone Polymeric Nanocarriers for Fine-Controlled Drug Release

2016 ◽  
Vol 17 (4) ◽  
pp. 1600295 ◽  
Author(s):  
Caiyan Zhao ◽  
Leihou Shao ◽  
Jianqing Lu ◽  
Chenying Zhao ◽  
Yujie Wei ◽  
...  
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Controlled Drug Release ◽  
Poly Ethylene Glycol ◽  
Polymeric Nanocarriers ◽  
Redox Responsive ◽  
Poly Ethylene
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