Complex micelles formed from two diblock copolymers for applications in controlled drug release

2009 ◽  
Vol 47 (7) ◽  
pp. 1804-1810 ◽  
Author(s):  
Guiying Li ◽  
Lei Guo ◽  
Songmei Ma ◽  
Junshen Liu
Keyword(s):  
Drug Release ◽  
Diblock Copolymers ◽  
Controlled Drug Release ◽  
Complex Micelles

Thermo- and oxidation-responsive supramolecular vesicles constructed from self-assembled pillar[6]arene-ferrocene based amphiphilic supramolecular diblock copolymers

2017 ◽  
Vol 8 (4) ◽  
pp. 682-688 ◽  
Author(s):  
Sai Wang ◽  
Chenhao Yao ◽  
Mengfei Ni ◽  
Zuqiang Xu ◽  
Ming Cheng ◽  
...  
Keyword(s):  
Drug Release ◽  
Diblock Copolymers ◽  
Controlled Drug Release ◽  
Self Assembled

Thermo- and oxidation-responsive pillar[6]arene-ferrocene based supramolecular vesicles were constructed for controlled drug release.

Fabrication of Complex Micelles with Tunable Shell for Application in Controlled Drug Release

2009 ◽  
Vol 9 (12) ◽  
pp. 1185-1193 ◽  
Author(s):  
Chenglin Wu ◽  
Rujiang Ma ◽  
Huan He ◽  
Lizhi Zhao ◽  
Hongjun Gao ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Complex Micelles

Fabrication of biofunctional complex micelles with tunable structure for application in controlled drug release

2014 ◽  
Vol 292 (7) ◽  
pp. 1675-1683 ◽  
Author(s):  
Lizhi Zhao ◽  
Chenglin Wu ◽  
Fang Wang ◽  
Anguo Ying ◽  
Chendiao Xu ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Tunable Structure ◽  
Complex Micelles

Temperature- and redox-responsive magnetic complex micelles for controlled drug release

2015 ◽  
Vol 3 (2) ◽  
pp. 260-269 ◽  
Author(s):  
Hui Zou ◽  
Weizhong Yuan
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Redox Responsive ◽  
Complex Micelles ◽  
Magnetic Complex

PCL-SS-PDMAEMA/Fe3O4 magnetic complex micelles can present dual temperature- and redox-responses, magnetism and magnetothermal properties.

Silica Nanotubes Decorated by pH-Responsive Diblock Copolymers for Controlled Drug Release

2015 ◽  
Vol 7 (6) ◽  
pp. 3618-3625 ◽  
Author(s):  
Jiemei Zhou ◽  
Wenjian Zhang ◽  
Chunyan Hong ◽  
Caiyuan Pan
Keyword(s):  
Drug Release ◽  
Diblock Copolymers ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Silica Nanotubes

Reducing the Risk in Controlled Drug Release by Using Tannic Acid in Liposomal Formulations

2018 ◽  
Vol 68 (12) ◽  
pp. 2925-2918
Author(s):  
Gabriela Cioca ◽  
Maricel Agop ◽  
Marcel Popa ◽  
Simona Bungau ◽  
Irina Butuc
Keyword(s):  
Drug Release ◽  
Tannic Acid ◽  
Release Rate ◽  
Controlled Drug Release ◽  
Toxicity Threshold ◽  
Release System ◽  
Liposomal Formulations ◽  
Cross Linker ◽  
Natural Cross

One of the main challenges in designing a release system is the possibility to control the release rate in order to maintain it at a constant value below a defined limit, to avoid exceeding the toxicity threshold. We propose a method of overcoming this difficulty by introducing the drug into liposomes, prior to its inclusion in the hydrogel. Furthermore, a natural cross linker (as is tannic acid) is used, instead of the toxic cross linkers commonly used, thus reducing the toxicity of the release system as a whole.

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

2018 ◽  
Vol 14 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Juliana M. Juarez ◽  
Jorgelina Cussa ◽  
Marcos B. Gomez Costa ◽  
Oscar A. Anunziata
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
The Body ◽  
Fickian Diffusion ◽  
Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

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