scholarly journals In vivo visible light-triggered drug release from an implanted depot

2015 ◽  
Vol 6 (1) ◽  
pp. 335-341 ◽  
Author(s):  
Carl-Johan Carling ◽  
Mathieu L. Viger ◽  
Viet Anh Nguyen Huu ◽  
Arnold V. Garcia ◽  
Adah Almutairi
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Degradable Polymer ◽  
On Demand ◽  
Triggered Drug Release

A visible light-degradable polymer allows on-demand in vivo photorelease of encapsulated dexamethasone from a subcutaneously implanted particle depot.

scholarly journals S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery

Research ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-11 ◽  
Author(s):  
Changping Wang ◽  
Chongyi Liu ◽  
Qiyao Wei ◽  
Lei Yang ◽  
Peng Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Visible Light ◽  
Cell Fate ◽  
Degradation Kinetics ◽  
Green Light ◽  
Anticancer Drug Delivery ◽  
On Demand ◽  
Facile Fabrication

Photocleavable hydrogels are of great importance in the field of controlled drug delivery, stem cell fate regulation, surface patterning, and intelligent devices. However, the development of novel photocleavable gel systems by visible light is usually met with challenges such as the lack of efficient and tunable photocleavable groups and reactions. Herein, we reported the facile fabrication of a new type of photocleavable hydrogels by the direct gelation of 4-arm thiol-terminated polyethylene glycol with 3,6-dichloro-1,2,4,5-tetrazine via the formation of S,S-tetrazine linkages. The prepared hydrogels underwent efficient degradation upon irradiation by ultraviolet or green light, and the degradation kinetics could be significantly promoted by hydrogen peroxide. Correspondingly, the hydrogels loaded with calcium peroxide microparticles or glucose oxidase/catalase enzymes enabled the precise and efficient in vivo photocontrol of gel degradation and drug release for cancer treatment. This work offers a promising and facile strategy towards the fabrication of visible light cleavable hydrogels with tunable and on-demand drug release properties.

scholarly journals Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system

2016 ◽  
Vol 52 (69) ◽  
pp. 10525-10528 ◽  
Author(s):  
Saemi O. Poelma ◽  
Seung Soo Oh ◽  
Sameh Helmy ◽  
Abigail S. Knight ◽  
G. Leslie Burnett ◽  
...  
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Small Molecules ◽  
Cancer Cells ◽  
Controlled Drug Release ◽  
Micellar System ◽  
On Demand ◽  
System P

We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules.

Two-component reduction-sensitive lipid–polymer hybrid nanoparticles for triggered drug release and enhanced in vitro and in vivo anti-tumor efficacy

2017 ◽  
Vol 5 (1) ◽  
pp. 98-110 ◽  
Author(s):  
Liu-Jie Zhang ◽  
Bo Wu ◽  
Wei Zhou ◽  
Cai-Xia Wang ◽  
Qian Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Two Component ◽  
Triggered Drug Release

Two-component reduction-sensitive lipid–polymer hybrid nanoparticles composed of DLPE-S-S-MPEG and PCL were developed for intracellular reduction triggered delivery of DOX.

NIR-Responsive Copolymer Upconversion Nanocomposites for Triggered Drug Release in Vitro and in Vivo

2018 ◽  
Vol 2 (1) ◽  
pp. 495-503 ◽  
Author(s):  
Yeye Zhang ◽  
Guangzhao Lu ◽  
Yuan Yu ◽  
He Zhang ◽  
Jie Gao ◽  
...  
Keyword(s):  
Drug Release ◽  
Triggered Drug Release ◽  
Release In Vitro

Visible-Light-Triggered Drug Release from TiO2 Nanotube Arrays: A Controllable Antibacterial Platform

2015 ◽  
Vol 128 (2) ◽  
pp. 603-607 ◽  
Author(s):  
Jingwen Xu ◽  
Xuemei Zhou ◽  
Zhida Gao ◽  
Yan-Yan Song ◽  
Patrik Schmuki
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Tio2 Nanotube Arrays ◽  
Tio2 Nanotube ◽  
Nanotube Arrays ◽  
Triggered Drug Release

Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release

2012 ◽  
Vol 48 (52) ◽  
pp. 6517 ◽  
Author(s):  
Moses Bio ◽  
Gregory Nkepang ◽  
Youngjae You
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Triggered Drug Release
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