scholarly journals Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system

2016 ◽  
Vol 52 (69) ◽  
pp. 10525-10528 ◽  
Author(s):  
Saemi O. Poelma ◽  
Seung Soo Oh ◽  
Sameh Helmy ◽  
Abigail S. Knight ◽  
G. Leslie Burnett ◽  
...  
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Small Molecules ◽  
Cancer Cells ◽  
Controlled Drug Release ◽  
Micellar System ◽  
On Demand ◽  
System P

We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules.

scholarly journals Photo-Responsive Supramolecular Micelles for Controlled Drug Release and Improved Chemotherapy

2020 ◽  
Vol 22 (1) ◽  
pp. 154
Author(s):  
Fasih Bintang Ilhami ◽  
Kai-Chen Peng ◽  
Yi-Shiuan Chang ◽  
Yihalem Abebe Alemayehu ◽  
Hsieh-Chih Tsai ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Visible Light ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Reactive Oxygen ◽  
Controlled Drug Release ◽  
Grand Challenge ◽  
Supramolecular System ◽  
Oxygen Species

Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular micelles (A-PPG), in order to achieve effective drug delivery combined with photo-chemotherapy. The resulting DOX/5-ALA-loaded micelles exhibited excellent light and pH-responsive behavior in aqueous solution and high drug-entrapment stability in serum-rich media. A short duration (1–2 min) of laser irradiation with visible light induced the dissociation of the DOX/5-ALA complexes within the micelles, which disrupted micellular stability and resulted in rapid, immediate release of the physically entrapped drug from the micelles. In addition, in vitro assays of cellular reactive oxygen species generation and cellular internalization confirmed the drug-loaded micelles exhibited significantly enhanced cellular uptake after visible light irradiation, and that the light-triggered disassembly of micellar structures rapidly increased the production of reactive oxygen species within the cells. Importantly, flow cytometric analysis demonstrated that laser irradiation of cancer cells incubated with DOX/5-ALA-loaded A-PPG micelles effectively induced apoptotic cell death via endocytosis. Thus, this newly developed supramolecular system may offer a potential route towards improving the efficacy of synergistic chemotherapeutic approaches for cancer.

scholarly journals A visible-light-controlled platform for prolonged drug release based on Ag-doped TiO2 nanotubes with a hydrophobic layer

2018 ◽  
Vol 9 ◽  
pp. 1793-1801 ◽  
Author(s):  
Caihong Liang ◽  
Jiang Wen ◽  
Xiaoming Liao
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Controlled Drug Release ◽  
Photocatalytic Decomposition ◽  
Light Illumination ◽  
Visible Light Illumination ◽  
Delivery Platform ◽  
Promising Application ◽  
Hydrophobic Layer ◽  
Prolonged Drug Release

In this work, a visible-light-controlled drug release platform was constructed for localized and prolonged drug release based on two-layer titania nanotubes (TNTs) fabricated using by an in situ voltage up-anodization process. The visible-light photocatalytic activity is improved by loading Ag onto the TNTs by NaBH4 reduction. Then, the TNTs containing Ag nanoparticles were modified with dodecanethiol (NDM) to create a hydrophobic layer. To demonstrate the visible-light-controlled drug release, the Zn2+ release behavior of the samples was investigated. In the initial 12 h, TNTs without NDM displayed a faster release rate with 29.4% Zn2+ release, which was more than three times that of the TNTs with NDM (8.7% Zn2+ release). Upon visible-light illumination, drug release from the sample coated with NDM was shown to increase due to the photocatalytic decomposition of NDM. The amount of released Zn2+ for this sample increased up to 71.9% within 12 h, indicating visible-light-controlled drug release. This drug release system may exhibit promising application as a localized, prolonged drug delivery platform.

scholarly journals Polymer microchamber arrays for geometry-controlled drug release: a functional study in human cells of neuronal phenotype

2019 ◽  
Vol 7 (6) ◽  
pp. 2358-2371 ◽  
Author(s):  
Olga Kopach ◽  
Kayiu Zheng ◽  
Olga A. Sindeeva ◽  
Meiyu Gai ◽  
Gleb B. Sukhorukov ◽  
...  
Keyword(s):  
Drug Release ◽  
Delivery System ◽  
Controlled Drug Release ◽  
Functional Study ◽  
Specific Drug ◽  
Polyelectrolyte Multilayer ◽  
Site Specific ◽  
Neuronal Phenotype ◽  
On Demand ◽  
Cargo Delivery

Polyelectrolyte multilayer (PEM) microchambers can provide a versatile cargo delivery system enabling rapid, site-specific drug release on demand.

Environment-stimulated nanocarriers enabling multi-active sites for high drug encapsulation as an “on demand” drug release system

2018 ◽  
Vol 6 (15) ◽  
pp. 2258-2273 ◽  
Author(s):  
F. R. Cheng ◽  
T. Su ◽  
J. Cao ◽  
X. L. Luo ◽  
Li Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Active Sites ◽  
Clinical Applications ◽  
Drug Encapsulation ◽  
High Drug ◽  
Release System ◽  
On Demand ◽  
System P ◽  
Drug Release System

Limited active sites in polyesters hinder fabrication of multifunctional biodegradable nanocarriers for successful clinical applications.

Nanocarriers with multi-locked DNA valves targeting intracellular tumor-related mRNAs for controlled drug release

Nanoscale ◽  
2017 ◽  
Vol 9 (44) ◽  
pp. 17318-17324 ◽  
Author(s):  
Yanhua Li ◽  
Yuanyuan Chen ◽  
Wei Pan ◽  
Zhengze Yu ◽  
Limin Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cancer Cells ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Normal Cells ◽  
Tremendous Challenge

The fabrication of well-behaved drug delivery systems that can transport drugs to specifically treat cancer cells rather than normal cells is still a tremendous challenge.

Remote-Controlled Drug Release from Graphene Oxide-Capped Mesoporous Silica to Cancer Cells by Photoinduced pH-Jump Activation

Langmuir ◽  
2014 ◽  
Vol 30 (24) ◽  
pp. 7182-7189 ◽  
Author(s):  
Dinggeng He ◽  
Xiaoxiao He ◽  
Kemin Wang ◽  
Zhen Zou ◽  
Xue Yang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Cancer Cells ◽  
Controlled Drug Release ◽  
Ph Jump

scholarly journals S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery

Research ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-11 ◽  
Author(s):  
Changping Wang ◽  
Chongyi Liu ◽  
Qiyao Wei ◽  
Lei Yang ◽  
Peng Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Visible Light ◽  
Cell Fate ◽  
Degradation Kinetics ◽  
Green Light ◽  
Anticancer Drug Delivery ◽  
On Demand ◽  
Facile Fabrication

Photocleavable hydrogels are of great importance in the field of controlled drug delivery, stem cell fate regulation, surface patterning, and intelligent devices. However, the development of novel photocleavable gel systems by visible light is usually met with challenges such as the lack of efficient and tunable photocleavable groups and reactions. Herein, we reported the facile fabrication of a new type of photocleavable hydrogels by the direct gelation of 4-arm thiol-terminated polyethylene glycol with 3,6-dichloro-1,2,4,5-tetrazine via the formation of S,S-tetrazine linkages. The prepared hydrogels underwent efficient degradation upon irradiation by ultraviolet or green light, and the degradation kinetics could be significantly promoted by hydrogen peroxide. Correspondingly, the hydrogels loaded with calcium peroxide microparticles or glucose oxidase/catalase enzymes enabled the precise and efficient in vivo photocontrol of gel degradation and drug release for cancer treatment. This work offers a promising and facile strategy towards the fabrication of visible light cleavable hydrogels with tunable and on-demand drug release properties.

Stimulus-responsive hydrogels reinforced by cellulose nanowhisker for controlled drug release

RSC Advances ◽  
2016 ◽  
Vol 6 (90) ◽  
pp. 87422-87432 ◽  
Author(s):  
Y. Chen ◽  
W. Y. Liu ◽  
G. S. Zeng
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Carboxymethyl Chitosan ◽  
Stimuli Responsive ◽  
Release System ◽  
Cellulose Nanowhisker ◽  
Hybrid Hydrogels ◽  
System P ◽  
Stimulus Responsive ◽  
Responsive Hydrogels

Hybrid hydrogels (W–C gels), composed of PDMAEMA, cellulose nanowhisker (CNW) and carboxymethyl chitosan (CMCS), were prepared for developing a stimuli-responsive drug-release system.

Fabrication of rod-like nanocapsules based on polylactide and 3,4-dihydroxyphenylalanine for a drug delivery system

RSC Advances ◽  
2015 ◽  
Vol 5 (125) ◽  
pp. 103414-103420 ◽  
Author(s):  
Dongjian Shi ◽  
Lei Zhang ◽  
Jiali Shen ◽  
Xiaojie Li ◽  
Mingqing Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
High Drug ◽  
Buffer Solutions ◽  
System P ◽  
Ph Buffer ◽  
High Drug Loading

Rod-like nanocapsules were facilely fabricated based on a bio-based polymer via DOPA adhesion. The nanocapsules showed high drug-loading efficacies and controlled drug release depending on different pH buffer solutions.

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