Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release

2012 ◽  
Vol 48 (52) ◽  
pp. 6517 ◽  
Author(s):  
Moses Bio ◽  
Gregory Nkepang ◽  
Youngjae You
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Triggered Drug Release

Visible-Light-Triggered Drug Release from TiO2 Nanotube Arrays: A Controllable Antibacterial Platform

2015 ◽  
Vol 128 (2) ◽  
pp. 603-607 ◽  
Author(s):  
Jingwen Xu ◽  
Xuemei Zhou ◽  
Zhida Gao ◽  
Yan-Yan Song ◽  
Patrik Schmuki
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Tio2 Nanotube Arrays ◽  
Tio2 Nanotube ◽  
Nanotube Arrays ◽  
Triggered Drug Release

scholarly journals Visible-Light-Triggered Drug Release from TiO2 Nanotube Arrays: A Controllable Antibacterial Platform

2015 ◽  
Vol 55 (2) ◽  
pp. 593-597 ◽  
Author(s):  
Jingwen Xu ◽  
Xuemei Zhou ◽  
Zhida Gao ◽  
Yan-Yan Song ◽  
Patrik Schmuki
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Tio2 Nanotube Arrays ◽  
Tio2 Nanotube ◽  
Nanotube Arrays ◽  
Triggered Drug Release

scholarly journals In vivo visible light-triggered drug release from an implanted depot

2015 ◽  
Vol 6 (1) ◽  
pp. 335-341 ◽  
Author(s):  
Carl-Johan Carling ◽  
Mathieu L. Viger ◽  
Viet Anh Nguyen Huu ◽  
Arnold V. Garcia ◽  
Adah Almutairi
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Degradable Polymer ◽  
On Demand ◽  
Triggered Drug Release

A visible light-degradable polymer allows on-demand in vivo photorelease of encapsulated dexamethasone from a subcutaneously implanted particle depot.

Facile synthesis of organosilica-capped mesoporous silica nanocarriers with selective redox-triggered drug release properties for safe tumor chemotherapy

2019 ◽  
Vol 7 (5) ◽  
pp. 1825-1832 ◽  
Author(s):  
Luying Shen ◽  
Shan Pan ◽  
Dechao Niu ◽  
Jianping He ◽  
Xiaobo Jia ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Facile Synthesis ◽  
Triggered Drug Release ◽  
Facile Route

We develop a facile route to synthesize organosilica-capped mesoporous silica nanocarriers for efficient and safe redox-triggered tumor chemotherapy.

scholarly journals Photo-Responsive Supramolecular Micelles for Controlled Drug Release and Improved Chemotherapy

2020 ◽  
Vol 22 (1) ◽  
pp. 154
Author(s):  
Fasih Bintang Ilhami ◽  
Kai-Chen Peng ◽  
Yi-Shiuan Chang ◽  
Yihalem Abebe Alemayehu ◽  
Hsieh-Chih Tsai ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Visible Light ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Reactive Oxygen ◽  
Controlled Drug Release ◽  
Grand Challenge ◽  
Supramolecular System ◽  
Oxygen Species

Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular micelles (A-PPG), in order to achieve effective drug delivery combined with photo-chemotherapy. The resulting DOX/5-ALA-loaded micelles exhibited excellent light and pH-responsive behavior in aqueous solution and high drug-entrapment stability in serum-rich media. A short duration (1–2 min) of laser irradiation with visible light induced the dissociation of the DOX/5-ALA complexes within the micelles, which disrupted micellular stability and resulted in rapid, immediate release of the physically entrapped drug from the micelles. In addition, in vitro assays of cellular reactive oxygen species generation and cellular internalization confirmed the drug-loaded micelles exhibited significantly enhanced cellular uptake after visible light irradiation, and that the light-triggered disassembly of micellar structures rapidly increased the production of reactive oxygen species within the cells. Importantly, flow cytometric analysis demonstrated that laser irradiation of cancer cells incubated with DOX/5-ALA-loaded A-PPG micelles effectively induced apoptotic cell death via endocytosis. Thus, this newly developed supramolecular system may offer a potential route towards improving the efficacy of synergistic chemotherapeutic approaches for cancer.

scholarly journals pH-triggered degradation and release of doxorubicin from zeolitic imidazolate framework-8 (ZIF8) decorated with polyacrylic acid

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9222-9234
Author(s):  
Vy Anh Tran ◽  
Sang-Wha Lee
Keyword(s):  
Drug Release ◽  
Polyacrylic Acid ◽  
Acidic Ph ◽  
Zeolitic Imidazolate Framework ◽  
Triggered Drug Release

The ZIF8–Dox@PAA nanocarrier demonstrated pH-triggered drug release through the detachment of the PAA layer along with the destruction of ZIF8 framework in acidic pH environment.

scholarly journals Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system

2016 ◽  
Vol 52 (69) ◽  
pp. 10525-10528 ◽  
Author(s):  
Saemi O. Poelma ◽  
Seung Soo Oh ◽  
Sameh Helmy ◽  
Abigail S. Knight ◽  
G. Leslie Burnett ◽  
...  
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Small Molecules ◽  
Cancer Cells ◽  
Controlled Drug Release ◽  
Micellar System ◽  
On Demand ◽  
System P

We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules.

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