Preparation and Biological Characterization of Polymeric Micelle Drug Carriers with Intracellular pH-Triggered Drug Release Property:  Tumor Permeability, Controlled Subcellular Drug Distribution, and Enhanced in Vivo Antitumor Efficacy

2005 ◽  
Vol 16 (1) ◽  
pp. 122-130 ◽  
Author(s):  
Younsoo Bae ◽  
Nobuhiro Nishiyama ◽  
Shigeto Fukushima ◽  
Hiroyuki Koyama ◽  
Matsumura Yasuhiro ◽  
...  
Keyword(s):  
Drug Release ◽  
Drug Distribution ◽  
Drug Carriers ◽  
Polymeric Micelle ◽  
Biological Characterization ◽  
Release Property ◽  
Triggered Drug Release ◽  
Tumor Permeability

Redox-responsive degradable honeycomb manganese oxide nanostructures as effective nanocarriers for intracellular glutathione-triggered drug release

2015 ◽  
Vol 51 (4) ◽  
pp. 776-779 ◽  
Author(s):  
Dinggeng He ◽  
Xiaoxiao He ◽  
Kemin Wang ◽  
Xue Yang ◽  
Xiaoxiao Yang ◽  
...  
Keyword(s):  
Drug Release ◽  
Manganese Oxide ◽  
Drug Carriers ◽  
New Class ◽  
Oxide Nanostructures ◽  
Redox Responsive ◽  
Intracellular Glutathione ◽  
Triggered Drug Release

Redox-responsive degradable honeycomb manganese oxide (hMnO2) nanostructures consisting of some lamellar MnO2 platelets were established as a new class of drug carriers for efficient intracellular GSH-triggered drug release.

Two-component reduction-sensitive lipid–polymer hybrid nanoparticles for triggered drug release and enhanced in vitro and in vivo anti-tumor efficacy

2017 ◽  
Vol 5 (1) ◽  
pp. 98-110 ◽  
Author(s):  
Liu-Jie Zhang ◽  
Bo Wu ◽  
Wei Zhou ◽  
Cai-Xia Wang ◽  
Qian Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Two Component ◽  
Triggered Drug Release

Two-component reduction-sensitive lipid–polymer hybrid nanoparticles composed of DLPE-S-S-MPEG and PCL were developed for intracellular reduction triggered delivery of DOX.

NIR-Responsive Copolymer Upconversion Nanocomposites for Triggered Drug Release in Vitro and in Vivo

2018 ◽  
Vol 2 (1) ◽  
pp. 495-503 ◽  
Author(s):  
Yeye Zhang ◽  
Guangzhao Lu ◽  
Yuan Yu ◽  
He Zhang ◽  
Jie Gao ◽  
...  
Keyword(s):  
Drug Release ◽  
Triggered Drug Release ◽  
Release In Vitro

scholarly journals MR imaging of model drug distribution in simulated vitreous

2015 ◽  
Vol 1 (1) ◽  
pp. 236-239 ◽  
Author(s):  
Sandra Stein ◽  
Christian Simroth-Loch ◽  
Sönke Langner ◽  
Stefan Hadlich ◽  
Oliver Stachs ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Ex Vivo ◽  
Drug Distribution ◽  
Injection Technique ◽  
Innovative Therapy ◽  
Age Related ◽  
The Impact

AbstractThe in vitro and in vivo characterization of intravitreal injections plays an important role in developing innovative therapy approaches. Using the established vitreous model (VM) and eye movement system (EyeMoS) the distribution of contrast agents with different molecular weight was studied in vitro. The impact of the simulated age-related vitreal liquefaction (VL) on drug distribution in VM was examined either with injection through the gel phase or through the liquid phase. For comparison the distribution was studied ex vivo in the porcine vitreous. The studies were performed in a magnetic resonance (MR) scanner. As expected, with increasing molecular weight the diffusion velocity and the visual distribution of the injected substances decreased. Similar drug distribution was observed in VM and in porcine eye. VL causes enhanced convective flow and faster distribution in VM. Confirming the importance of the injection technique in progress of VL, injection through gelatinous phase caused faster distribution into peripheral regions of the VM than following injection through liquefied phase. VM and MR scanner in combination present a new approach for the in vitro characterization of drug release and distribution of intravitreal dosage forms.

In vitro and in vivo biological characterization of the anti-proliferative potential of a cyclic trinuclear organotin(iv) complex

2016 ◽  
Vol 12 (3) ◽  
pp. 1015-1023 ◽  
Author(s):  
Marta Martins ◽  
Pedro V. Baptista ◽  
Ana Soraia Mendo ◽  
Claudia Correia ◽  
Paula Videira ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Proliferative Potential ◽  
Biological Characterization ◽  
Growth Of Tumor

Identification of novel molecules that can selectively inhibit the growth of tumor cells, is of utmost importance.

scholarly journals The Biology of COP Cells: Mesenchymal of Hematopoietic?

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 45-45
Author(s):  
Meghan McGee-Lawrence
Keyword(s):  
Stem Cells ◽  
Clinical Practice ◽  
Progenitor Cells ◽  
Peripheral Blood ◽  
Biological Characterization ◽  
Differentiation Capacity ◽  
Growing Body

Abstract Circulating osteogenic precursor (COP) cells constitute a recently discovered population of circulating progenitor cells with the capacity to form not only bone but other mesenchymal tissues. A small but growing body of literature explores these cells, but with a great deal of disagreement and contradiction within it, mainly whether these cells are from mesenchymal or hematopoietic origin. This session will discuss the origins and biological characterization of these cells, including the identification strategies used to isolate these cells from the peripheral blood. It also examines the available knowledge on the in vitro and in vivo behaviour of these cells in plastic adherence, differentiation capacity, proliferation, and cellular homing. We will also review the profound and exciting implications for future use of COP cells in clinical practice, particularly in comparison with other types of stem cells.

Sign in / Sign up

Export Citation Format

Share Document