Chronic toxicity of crude ricinine in rats assessed by1H NMR metabolomics analysis

RSC Advances ◽  
2015 ◽  
Vol 5 (34) ◽  
pp. 27018-27028 ◽  
Author(s):  
Pingping Guo ◽  
Dandan Wei ◽  
Junsong Wang ◽  
Ge Dong ◽  
Qian Zhang ◽  
...  
Keyword(s):  
Castor Bean ◽  
Chronic Toxicity ◽  
Nmr Metabolomics ◽  
H Nmr ◽  
First Time ◽  
Metabolomics Analysis

A1H-NMR based metabolomics approach combined with OSC-PLS-DA was applied to investigate the chronic toxicity of crude ricinine from castor bean shell in rats for the first time.

NMR-based metabolomics approach to study the chronic toxicity of crude ricin from castor bean kernels on rats

2014 ◽  
Vol 10 (9) ◽  
pp. 2426-2440 ◽  
Author(s):  
Pingping Guo ◽  
Junsong Wang ◽  
Ge Dong ◽  
Dandan Wei ◽  
Minghui Li ◽  
...  
Keyword(s):  
Castor Bean ◽  
Chronic Toxicity ◽  
First Time

NMR based metabolomics approach combined with OSC-PLSDA was applied to investigate the chronic toxicity of crude ricin from castor bean kernels on rats for the first time.

scholarly journals Putative imbalanced amino acid metabolism in rainbow trout long term fed a plant-based diet as revealed by 1H-NMR metabolomics

2021 ◽  
Vol 10 ◽  
Author(s):  
Catherine Deborde ◽  
Blandine Madji Hounoum ◽  
Annick Moing ◽  
Mickaël Maucourt ◽  
Daniel Jacob ◽  
...  
Keyword(s):  
Amino Acids ◽  
Rainbow Trout ◽  
Amino Acid ◽  
Amino Acid Content ◽  
Proton Nuclear Magnetic Resonance ◽  
Free Form ◽  
Metabolomic Analysis ◽  
Nmr Metabolomics ◽  
H Nmr

Abstract The long-term effect of a plant (P)-based diet was assessed by proton nuclear magnetic resonance (1H-NMR) metabolomics in rainbow trout fed a marine fish meal (FM)–fish oil (FO) diet (M), a P-based diet and a control commercial-like diet (C) starting with the first feeding. Growth performances were not heavily altered by long-term feeding on the P-based diet. An 1H-NMR metabolomic analysis of the feed revealed significantly different soluble chemical compound profiles between the diets. A set of soluble chemical compounds was found to be specific either to the P-based diet or to the M diet. Pterin, a biomarker of plant feedstuffs, was identified both in the P-based diet and in the plasma of fish fed the P-based diet. 1H-NMR metabolomic analysis on fish plasma and liver and muscle tissues at 6 and 48 h post feeding revealed significantly different profiles between the P-based diet and the M diet, while the C diet showed intermediate results. A higher amino acid content was found in the plasma of fish fed the P-based diet compared with the M diet after 48 h, suggesting either a delayed delivery of the amino acids or a lower amino acid utilisation in the P-based diet. This was associated with an accumulation of essential amino acids and the depletion of glutamine in the muscle, together with an accumulation of choline in the liver. Combined with an anticipated absorption of methionine and lysine supplemented in free form, the present results suggest an imbalanced essential amino acid supply for protein metabolism in the muscle and for specific functions of the liver.

Synthesis and characterization of meso-to-meso directly linked porphyrin-diazaporphyrin triads

2018 ◽  
Vol 22 (09n10) ◽  
pp. 814-820
Author(s):  
Yingying Jia ◽  
Ling Xu ◽  
Bangshao Yin ◽  
Mingbo Zhou ◽  
Jianxin Song
Keyword(s):  
Nickel Complex ◽  
High Resolution Mass Spectrometry ◽  
Dihedral Angles ◽  
X Ray Diffraction ◽  
Extinction Coefficients ◽  
X Ray ◽  
H Nmr ◽  
First Time ◽  
Molar Extinction Coefficients

Beginning with 5,10,15-triarylporphyrin-nickel complex, five meso-to-meso directly linked porphyrin-diazaporphyrin triads were successfully prepared for the first time through a series of reactions including formylation via Vilsmeier–Haack reaction, condensation with pyrrole, bromination with [Formula: see text]-Bromosuccinimide (NBS), oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), metal-templated cyclization of dibromodipyrrin-metal complexes with NaN[Formula: see text] and demetalization. All these triads were comprehensively characterized by [Formula: see text]H NMR, high-resolution mass spectrometry and UV-vis absorption. In addition, the structure of compound 6Ni was unambiguously determined by X-ray diffraction analysis, which showed that the two dihedral angles are both 86.65 (4)[Formula: see text] between each mean plane of porphyrin and that of central diazaporphyrin The UV-vis absorption spectra disclosed that the longest wavelengths of Soret bands and Q bands for these triads were observed at 429 and 642 nm, respectively. In contrast to diazaporphyrin-porphyrin dyads, diazaporphyrin dimers and diazaporphyrin monomers reported previously the molar extinction coefficients, particularly for triad 8Ni are much higher.

scholarly journals New Method for Nucleophilic Substitution on Hexachlorocyclotriphosphazene by Allylamine Using an Algerian Proton Exchanged Montmorillonite Clay (Maghnite-H+) as a Green Solid Catalyst

2016 ◽  
Vol 11 (2) ◽  
pp. 151 ◽  
Author(s):  
Lahouaria Medjdoub ◽  
Belbachir Mohammed
Keyword(s):  
Nucleophilic Substitution ◽  
Room Temperature ◽  
Montmorillonite Clay ◽  
New Method ◽  
Solid Catalyst ◽  
H Nmr ◽  
Flight Mass Spectrometry ◽  
Crystalline Product ◽  
First Time ◽  
C Nmr

<p>Nucleophilic substitution on hexachlorocyclotriphosphazene (HCCTP) with allylamine in order to give hexa(allylamino)cyclotriphosphazene (HACTP)  is performed for the first time under mild conditions by using diethylether as solvent to replace benzene which is very toxic. The reaction time is reduced to half and also performed at room temperature but especially in the presence of an eco-catalyst called Maghnite-H<sup>+</sup>. This catalyst has a significant role in the industrial scale. In fact, the use of Maghnite is preferred for its many advantages: a very low purchase price compared to other catalysts, the easy removal of the reaction mixture. Then, Maghnite-H<sup>+</sup> is became an excellent catalyst for many chemical reactions. The structure of HACTP synthesized in the presence of Maghnite-H<sup>+</sup> to 5% by weight is confirmed by <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, <sup>31</sup>P-NMR (Nuclear magnetic resonance) and FTIR (Fourier Transform Infrared spectroscopy). MALDI-TOF (Matrix-Assisted Laser Desorption/Ionisation-time-of-flight mass spectrometry) is used to establish the molecular weight of HACTP which is 471 g/mol. DSC (Differential Scanning Calorimetery) and TGA (Thermogravimetric Analysis) show that HACTP is a crystalline product with a melting point of 88 °C. It is reactive after melting but is degraded from 230 °C. Copyright © 2016 BCREC GROUP. All rights reserved</p><p><em>Received: 28<sup>th</sup> September 2015; Revised: 5<sup>th</sup> December 2015; Accepted: 4<sup>th</sup> January 2016</em></p><p><strong>How to Cite</strong>: Medjdoub, L., Mohammed, B. (2016). New Method for Nucleophilic Substitution on Hexachlorocyclotriphosphazene by Allylamine Using an Algerian Proton Exchanged Montmorillonite Clay (Maghnite-H+) as a Green Solid Catalyst. <em>Bulletin of Chemical Reaction Engineering &amp; Catalysis</em>, 11 (2): 151-160 (doi:10.9767/bcrec.11.2.541.151-160)</p><p><strong>Permalink/DOI:</strong> http://dx.doi.org/10.9767/bcrec.11.2.541.151-160</p>

scholarly journals Structural and In Silico Characterization of Small Molecules Isolated from Eichhornia crassipes

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Andrew Mtewa ◽  
Duncan C. Sesaazi ◽  
Fanuel Lampiao
Keyword(s):  
In Silico ◽  
Eichhornia Crassipes ◽  
Cytochrome P450 Enzymes ◽  
Anticancer Activities ◽  
H Nmr ◽  
Cytotoxic Compounds ◽  
In Silico Characterization ◽  
First Time ◽  
Nonanedioic Acid

Eichhornia crassipes has been reported to have various medicinal properties including anticancer activities. The plant was collected from the Shire river in Malawi, and two cytotoxic compounds, benzene-1,4-diol and nonanedioic acid, were isolated and characterized for the first time in the leaves and roots of the plant. 1H NMR, COSY, HSQC, HMBC, 13-C, and LCMS spectroscopic experimental techniques were used to identify the compounds in their pure forms. In silico experiments showed that both compounds do not have AMES toxicity and do not inhibit cytochrome P450 enzymes, but nonanedioic acid acts as a CYP2D6 substrate. This work showed that Eichhornia crassipes can be considered to have a role as a source of potential hits and leads to drug development that can be rationally optimized for drugs.

scholarly journals Comparative Study of Chemical Composition and Biological Activity of Yellow, Green, Brown, and Red Brazilian Propolis

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Christiane Schineider Machado ◽  
João Benhur Mokochinski ◽  
Tatiana Onofre de Lira ◽  
Fátima de Cassia Evangelista de Oliveira ◽  
Magda Vieira Cardoso ◽  
...  
Keyword(s):  
Biological Activity ◽  
Chemical Composition ◽  
Quality Standard ◽  
Antimicrobial Activities ◽  
Mato Grosso ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Chemical Profiles ◽  
Brazilian Propolis ◽  
First Time

The chemical composition and biological activity of a sample of yellow propolis from Mato Grosso do Sul, Brazil (EEP-Y MS), were investigated for the first time and compared with green, brown, and red types of Brazilian propolis and with a sample of yellow propolis from Cuba. Overall, EEP-Y MS had different qualitative chemical profiles, as well as different cytotoxic and antimicrobial activities when compared to the other types of propolis assessed in this study and it is a different chemotype of Brazilian propolis. Absence of phenolic compounds and the presence of mixtures of aliphatic compounds in yellow propolis were determined by analysing1H-NMR spectra and fifteen terpenes were identified by GC-MS. EEP-Y MS showed cytotoxic activity against human tumour strain OVCAR-8 but was not active against Gram-negative or Gram-positive bacteria. Our results confirm the difficulty of establishing a uniform quality standard for propolis from diverse geographical origins. The most appropriate pharmacological applications of yellow types of propolis must be further investigated.

Preparation of New Anti-Slip Flooring Coatings: Hydrophobic MMA Floor Coatings

2013 ◽  
Vol 721 ◽  
pp. 73-76
Author(s):  
Shu Le Lin ◽  
Hui Hua Cai
Keyword(s):  
Electronic Spectroscopy ◽  
Dynamic Contact ◽  
Contact Angles ◽  
Coating Properties ◽  
Hydrophobic Properties ◽  
X Ray ◽  
H Nmr ◽  
Potential Applications ◽  
Ft Ir ◽  
First Time

For the first time, hydrophobic MMA floor coatings were prepared based on the fluorine-containing methacrylic ester copolymers and applied as a new kind of anti-slip flooring coatings. The composition of the synthesized copolymers was characterized by FT-IR and 1H-NMR. The prepared hydrophobic MMA floor coatings were analyzed for their coating properties. The hydrophobic properties of the coatings were characterized by static and dynamic contact angles and X-ray photo-electronic spectroscopy (XPS). Results show that the newly prepared floor coatings are easy to apply and have excellent mechanical and hydrophobic properties, which indicates that the hydrophobic MMA floor coatings have great potential applications in anti-slip flooring coatings.

scholarly journals The hydrolysis of geminal ethers: a kinetic appraisal of orthoesters and ketals

2016 ◽  
Vol 12 ◽  
pp. 1467-1475 ◽  
Author(s):  
Sonia L Repetto ◽  
James F Costello ◽  
Craig P Butts ◽  
Joseph K W Lam ◽  
Norman M Ratcliffe
Keyword(s):  
Water Contamination ◽  
Jet Fuel ◽  
Computational Studies ◽  
Water Interface ◽  
H Nmr ◽  
Novel Approach ◽  
Rapid Hydrolysis ◽  
First Time ◽  
Hydrolysis Of ◽  
Hydrolysis Reactions

A novel approach to protecting jet fuel against the effects of water contamination is predicated upon the coupling of the rapid hydrolysis reactions of lipophilic cyclic geminal ethers, with the concomitant production of a hydrophilic acyclic hydroxyester with de-icing properties (Fuel Dehydrating Icing Inhibitors - FDII). To this end, a kinetic appraisal of the hydrolysis reactions of representative geminal ethers was undertaken using a convenient surrogate for the fuel–water interface (D2O/CD3CN 1:4). We present here a library of acyclic and five/six-membered cyclic geminal ethers arranged according to their hydroxonium catalytic coefficients for hydrolysis, providing for the first time a framework for the development of FDII. A combination of 1H NMR, labelling and computational studies was used to assess the effects that may govern the observed relative rates of hydrolyses.

Assessment of 1 H NMR-based metabolomics analysis for normalization of urinary metals against creatinine

2017 ◽  
Vol 464 ◽  
pp. 37-43 ◽  
Author(s):  
Marc Cassiède ◽  
Sindhu Nair ◽  
Meghan Dueck ◽  
James Mino ◽  
Ryan McKay ◽  
...  
Keyword(s):  
H Nmr ◽  
Metabolomics Analysis
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