scholarly journals Comparative Study of Chemical Composition and Biological Activity of Yellow, Green, Brown, and Red Brazilian Propolis

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Christiane Schineider Machado ◽  
João Benhur Mokochinski ◽  
Tatiana Onofre de Lira ◽  
Fátima de Cassia Evangelista de Oliveira ◽  
Magda Vieira Cardoso ◽  
...  
Keyword(s):  
Biological Activity ◽  
Chemical Composition ◽  
Quality Standard ◽  
Antimicrobial Activities ◽  
Mato Grosso ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Chemical Profiles ◽  
Brazilian Propolis ◽  
First Time

The chemical composition and biological activity of a sample of yellow propolis from Mato Grosso do Sul, Brazil (EEP-Y MS), were investigated for the first time and compared with green, brown, and red types of Brazilian propolis and with a sample of yellow propolis from Cuba. Overall, EEP-Y MS had different qualitative chemical profiles, as well as different cytotoxic and antimicrobial activities when compared to the other types of propolis assessed in this study and it is a different chemotype of Brazilian propolis. Absence of phenolic compounds and the presence of mixtures of aliphatic compounds in yellow propolis were determined by analysing1H-NMR spectra and fifteen terpenes were identified by GC-MS. EEP-Y MS showed cytotoxic activity against human tumour strain OVCAR-8 but was not active against Gram-negative or Gram-positive bacteria. Our results confirm the difficulty of establishing a uniform quality standard for propolis from diverse geographical origins. The most appropriate pharmacological applications of yellow types of propolis must be further investigated.

scholarly journals Chemical Composition and Antimicrobial Activity of Wild Garlic Allium ursinum of Bulgarian Origin

2009 ◽  
Vol 4 (8) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Antoaneta Ivanova ◽  
Bozhanka Mikhova ◽  
Hristo Najdenski ◽  
Iva Tsvetkova ◽  
Ivanka Kostova
Keyword(s):  
Antimicrobial Activity ◽  
Chemical Composition ◽  
Antimicrobial Activities ◽  
Sulfur Compounds ◽  
Volatile Components ◽  
Butanol Extract ◽  
Allium Ursinum ◽  
Antifungal Properties ◽  
First Time ◽  
Wild Garlic

The chemical composition of fresh flowers from Allium ursinum (ramsons, bear's garlic, wild garlic) growing in Bulgaria has been studied. Thymidine (1), adenosine (2), astragalin (kaempferol-3-O-β-D-glucopyranoside (3), kaempferol-3-O-D-glucopyranosyl-7-O-D-glucopyranoside (4), kaempferol-3-O-D-neohesperoside (5), and kaempferol-3-O-D-neohesperoside-7-O-D-glucopyranoside (6) were isolated from the n-butanol extract and identified by different spectroscopic and spectrometric methods. Thymine (7), uridine (8), uracil (9) and 5-chloro-uridine (10) were detected in the same extract by GC-MS. This is the first report of the occurrence of 1, 2, 4, 7 – 10 in the flowers of A. ursinum. GC-MS of the volatile components of fresh flowers and leaves from the same plant revealed a high content of sulfur compounds, some of which are reported for the first time for A. ursinum. The antimicrobial activities of extracts from fresh flowers and leaves of A. ursinum have been tested; some extracts exhibited moderate antifungal properties.

scholarly journals Antimicrobial Activity and Chemical Composition of Essential Oil of Eupatorium Glutinosum (Lam.)

2006 ◽  
Vol 1 (8) ◽  
pp. 1934578X0600100
Author(s):  
Hesham R. El-Seedi
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Steam Distillation ◽  
Antimicrobial Activities ◽  
Plant Residue ◽  
Volatile Fraction ◽  
Positive Bacterium ◽  
Medicinal Uses ◽  
Study Support ◽  
First Time

The essential oil obtained by steam distillation from the leaves and twigs of Eupatorium glutinosum Lam. (Asteraceae) showed antimicrobial activities against a Gram-positive bacterium, three Gram–negative bacteria and three fungi. The results from this study support the vernacular medicinal uses of the plant in folkloric medicine. The chemical composition of the essential oil was analysed by GC and GC-MS, resulting in the identification of 24 constituents accounting for 92.6% of the total mass. The major active component, carvacrol, was isolated using MPLC and characterized by NMR and MS analysis. β-Glucosidase-treatment of the aqueous plant residue yielded a volatile fraction that did not show antimicrobial activitiy, in which the major components were octen-3-ol and (Z)-hex-2-en-1-ol. The essential oil from the species is reported for the first time.

Synthesis and in vitro Biological Activity of New 4,6-Disubstituted 3(2H)-Pyridazinone-acetohydrazide Derivatives

2012 ◽  
Vol 67 (5-6) ◽  
pp. 257-265
Author(s):  
Murat Sukuroglu ◽  
Tijen Onkol ◽  
Fatma Kaynak Onurdağ ◽  
Gulsen Akalın ◽  
M. Fethi Şahin
Keyword(s):  
Biological Activity ◽  
Antimicrobial Activities ◽  
Cytotoxic Activities ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
E Coli ◽  
Preliminary Results ◽  
H Nmr ◽  
Pyridazinone Derivatives

New 3(2H)-pyridazinone derivatives containing a N’-benzyliden-acetohydrazide moiety at position 2 were synthesized. The structures of these newly synthesized compounds were confi rmed by IR, 1H NMR, and MS data. These compounds were tested for their antibacterial, antifungal, antimycobacterial, and cytotoxic activities. The compounds 2-[4-(4-chlorophenyl)- 6-(morpholin-4-yl)-3-oxo-(2H)-pyridazin-2-yl]-N’-(4-tert-butylbenzyliden)acetohydrazide and 2-[4-(4-chlorophenyl)-6-(morpholin-4-yl)-3-oxo-(2H)-pyridazin-2-yl]-N’-(4-chlorobenzyliden) acetohydrazide exhibited activity against both Gram-positive and Gram-negative bacteria. Most of the compounds were active against E. coli ATCC 35218. The preliminary results of this study revealed that some target compounds exhibited promising antimicrobial activities

scholarly journals Biogenetic Conversion of Wyerone and Dihydrowyerone into Wyerone Epoxide in Vicia faba Cotyledons and Screening of Antibacterial Activity

2018 ◽  
Vol 2018 ◽  
pp. 1-7
Author(s):  
Nedhal A. Al-Douri ◽  
Randa N. Haddadin ◽  
Ashok K. Shakya ◽  
Ghaleb A. Oriquat
Keyword(s):  
Antibacterial Activity ◽  
Vicia Faba ◽  
Antibacterial Activities ◽  
Antimicrobial Activities ◽  
Stress Factors ◽  
Gram Positive Bacteria ◽  
The Family ◽  
Zones Of Inhibition ◽  
Plant Produce ◽  
First Time

Background. Vicia faba is a plant that belongs to the family Fabaceae. Cotyledons of this plant produce compounds called phytoalexins as a result of fungal and bacterial infection or stress factors. The phytoalexins are furanoacetylenic compounds. They include wyerone, wyerol, wyerone acid, their dihydro derivatives, and wyerone epoxide. These compounds have antimicrobial activities mainly against fungi. Objective. The purpose of this study was to elucidate the biogenetic conversion of wyerone and dihydrowyerone to wyerone epoxide in V. faba and to investigate the antibacterial activities of some of these phytoalexins. Materials and Methods. Seeds of Vicia faba were used. Labelled wyerone and dihydrowyerone were obtained by treating CuCl2-induced cotyledons with sodium (2-14C) acetate and separated by TLC and HPLC. Labelled wyerone and dihydrowyerone were then applied to induced bean cotyledons to establish any possible interconversion to wyerone epoxide. Antibacterial activity of wyerone, wyerone acid, and wyerone epoxide was investigated by disc diffusion test against a panel of microorganisms. Zones of inhibition were reported. Results. The radiolabeling studies showed that 12.4% of 14C-wyerone, and 6.01% of 14C-dihydrowyerone were incorporated into wyerone epoxide. This indicates that wyerone epoxide was most probably derived from wyerone and dihydrowyerone. In addition, a new compound, 11-hydroxywyerone was isolated for the first time. Additionally, this study showed that wyerone, wyerone epoxide, and wyerone acid had no antibacterial activity against Gram-negative bacteria but were active against Gram-positive bacteria.

scholarly journals Comparative Chemistry of Propolis from Eight Brazilian Localities

2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
A. A. Righi ◽  
G. Negri ◽  
A. Salatino
Keyword(s):  
Chemical Composition ◽  
Caffeoylquinic Acids ◽  
Prenylated Flavonoids ◽  
Cabo Verde ◽  
Paulo State ◽  
Red Color ◽  
Minas Gerais State ◽  
Chemical Profiles ◽  
Plant Exudates ◽  
Brazilian Propolis

Propolis is a complex honeybee product with resinous aspect, containing plant exudates and beeswax. Their color, texture, and chemical composition vary, depending on the location of the hives and local flora. The most studied Brazilian propolis is the green (alecrim-do-campo) type, which contains mainly prenylated phenylpropanoids and caffeoylquinic acids. Other types of propolis are produced in Brazil, some with red color, others brown, grey, or black. The aim of the present work was to determine the chemical profiles of alcohol and chloroform extracts of eight samples of propolis, corresponding to six Brazilian regions. Methanol and chloroform extracts were obtained and analyzed by HPLC/DAD/ESI/MS and GC/MS. Two chemical profiles were recognized among the samples analyzed: (1) black Brazilian propolis, characterized chiefly by flavanones and glycosyl flavones, stemming from Picos (Piauí state) and Pirenópolis (Goiás state); (2) green Brazilian propolis, characterized by prenylated phenylpropanoids and caffeoylquinic acids, stemming from Cabo Verde (Bahia state), Lavras and Mira Bela (Minas Gerais state), Pariquera-Açu and Bauru (São Paulo state), and Ponta Grossa (Paraná state). The present work represents the first report of prenylated flavonoids in Brazilian propolis and schaftoside (apigenin-8-C-glucosyl-6-C-arabinose) in green propolis.

scholarly journals Essential Oil of Galinsoga Parviflora Leaves from Colombia

2010 ◽  
Vol 5 (11) ◽  
pp. 1934578X1000501
Author(s):  
Jorge A. Pino ◽  
Mauricio Gaviria ◽  
Juana Quevedo-Vega ◽  
Laura García-Lesmes ◽  
Clara E. Quijano-Celis
Keyword(s):  
Staphylococcus Aureus ◽  
Chemical Composition ◽  
Essential Oil ◽  
Bacillus Cereus ◽  
Volatile Compounds ◽  
Antimicrobial Activities ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Leaf Oil

The chemical composition of the volatile compounds from the leaves of Galinsoga parviflora Cav. (Asteraceae) from Colombia was studied by GC and GC/MS. Eighty-eight volatile compounds were identified, of which the major ones were (Z)-3-hexen-1-ol (21.7%), β-caryophyllene (12.4%), and 6-demethoxy-ageratochrome (14%). The leaf oil presented antimicrobial activities against the Gram-positive bacteria Staphylococcus aureus and Bacillus cereus.

scholarly journals Chemical Composition and Pharmacological Effects of Geopropolis Produced byMelipona quadrifasciata anthidioides

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Cintia Miranda dos Santos ◽  
Jaqueline Ferreira Campos ◽  
Helder Freitas dos Santos ◽  
José Benedito Perrella Balestieri ◽  
Denise Brentan Silva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chemical Composition ◽  
Antimicrobial Activities ◽  
Pharmacological Effects ◽  
Antimicrobial Drug Resistance ◽  
Gram Positive Bacteria ◽  
Microbial Infections ◽  
Inflammatory Processes ◽  
Anti Inflammatory ◽  
Hydroethanolic Extract

Stingless bees produce geopropolis, which is popularly described for its medicinal properties, but for which few scientific studies have demonstrated pharmacological effects. The objective of this study was to investigate the chemical composition of the geopropolis ofMelipona quadrifasciata anthidioidesand to evaluate its antioxidant, antimutagenic, anti-inflammatory, and antimicrobial activities. The composition of the hydroethanolic extract of geopropolis (HEG) included di- and trigalloyl and phenylpropanyl heteroside derivatives, flavanones, diterpenes, and triterpenes. HEG showed antioxidant action via the direct capture of free radicals and by inhibiting the levels of oxidative hemolysis and malondialdehyde in human erythrocytes under oxidative stress. HEG also reduced the frequency of gene conversion and the number of mutant colonies ofS. cerevisiae. The anti-inflammatory action of HEG was demonstrated by the inhibition of hyaluronidase enzyme activity. In addition, HEG induced cell death in all evaluated gram-positive bacteria, gram-negative bacteria, and yeasts, including clinical isolates with antimicrobial drug resistance. Collectively, these results demonstrate the potential ofM. q. anthidioidesgeopropolis for the prevention and treatment of various diseases related to oxidative stress, mutagenesis, inflammatory processes, and microbial infections.

scholarly journals Synthesis and Pharmacological Evaluation of Some New 2-Phenyl benzimidazoles Derivatives and their Schiff's Bases

2009 ◽  
Vol 6 (s1) ◽  
pp. S342-S346 ◽  
Author(s):  
Y. S. Chhonker ◽  
B. Veenu ◽  
S. R. Hasim ◽  
Niranjan Kaushik ◽  
Devendra Kumar ◽  
...  
Keyword(s):  
Antimicrobial Activities ◽  
Benzimidazole Derivatives ◽  
Spectroscopic Techniques ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Ir Spectroscopic

Some new 2- phenyl benzimidazole derivatives were synthesised by cyclocondensation with appropriate reagents. The compounds synthesised were identified by1H NMR, FAB Mass and FT-IR spectroscopic techniques. All compounds studied in this work were screened for theirin vitroantimicrobial activities against the standard strains:Staphylococcus aureusATCC - 25923, ATCC - 441 andBacillus subtilisATCC- 6633 as gram positive,Escherichia coliATCC - 11775 andPseudomonas aeruginosaATCC 10145 as gram negative bacteria. Some of the compounds inhibited the growth of gram-positive bacteria (B. subtilisandS. aureus) at MIC values between 25 and 200 mg/mL. Some of the compounds exhibit antimicrobial activity against gram negative bacteria (E. coliandP. Aeruginosa) MIC values between 25 and 200 mg/mL.

scholarly journals Synthesis of Silver Abietate as an Antibacterial Agent for Textile Applications

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
A. Yıldız ◽  
M. Değirmencioğlu
Keyword(s):  
Textile Industry ◽  
Antibacterial Agent ◽  
Abietic Acid ◽  
Antibacterial Activities ◽  
Test Method ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Agar Diffusion Test ◽  
New Compounds ◽  
First Time

This study explored the potential use of new silver abietate obtained from abietic acid as an antibacterial agent for textile applications. Synthesis, structure, and antibacterial studies of silver abietate compound are reported. Silver complex was obtained reacting abietic acid with silver. The new compounds were characterized by1H NMR,13C NMR, DEPT, IR, UV, and ESI-MS techniques which support the proposed structures. The new Ag abietate complex has no environmental hazard, its antibacterial activities were evaluated after being applied to cotton fabric by padding process according to the JIS L 1902-2008 agar diffusion test method and against three Gram-negative and three Gram-positive bacteria, respectively. Stability of antibacterial effect after repeated washings (3, 5, 10, and 20) was also tested which indicated that the synthesized silver abietate compound could be used as a new antibacterial agent in textile industry. In this way, the compound has been synthesized the first time in the literature and the applications have been investigated.

scholarly journals SPECIES OF THE GENUS ALCHEMILLA L. (ROSACEAE): CHEMICAL COMPOSITION, BIOLOGICAL ACTIVITY AND USE IN MEDICINE (REVIEW)

2019 ◽  
pp. 5-22
Author(s):  
Ирина (Irina) Евгеньевна (Evgenievna) Лобанова (Lobanova) ◽  
Галина (Galina) Ивановна (Ivanovna) Высочина (Vysochina) ◽  
Наталья (Natal'ya) Алексеевна (Alekseevna) Мазуркова (Mazurkova) ◽  
Татьяна (Tat'yana) Абдулхаиловна (Abdulkhailovna) Кукушкина (Kukushkina) ◽  
Екатерина (Ekaterina) Игоревна (Igorevna) Филиппова (Filippova)
Keyword(s):  
Biological Activity ◽  
Chemical Composition ◽  
Raw Materials ◽  
Medical Application ◽  
Difficult Genus ◽  
Wide Range ◽  
Active Research ◽  
Vegetable Raw Materials ◽  
First Time ◽  
Medicine Review

Data about on taxonomy of Alchemilla L.genus, distribution of Alchemilla species in world flora, use in traditional and official medicine of the different countries are presented. Questions of chemical composition, biological activity and pharmacological studying are considered. It is shown that in the last decades in Russia there is an active research of Alchemilla species at the level of regional and local floras. Species of this difficult genus in the systematic relation are offered to be used as the vegetable medicinal raw materials of different function containing compounds of different chemical classes and possessing a wide range of biological activity. As a result of complex studying with application of the latest methods of a research and standardization of vegetable raw materials a lady's mantle on existence and content of the main active ingredients 13 types of the Alchemilla species growing in Russia have been recommended for medical application. For the first time researches on antiviral activity of preparations from plant extracts of Alchemilla vulgaris L.s.I concerning some RNA - and DNA - genomic viruses are discussed. Analysis of the literature data reveals the prospects for the use of species of the genus Alchemilla.

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