Hollow mesoporous hydroxyapatite nanoparticles (hmHANPs) with enhanced drug loading and pH-responsive release properties for intracellular drug delivery

2013 ◽  
Vol 1 (19) ◽  
pp. 2447 ◽  
Author(s):  
Ya-Huei Yang ◽  
Chia-Hung Liu ◽  
Yung-He Liang ◽  
Feng-Huei Lin ◽  
Kevin C.-W. Wu
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Hydroxyapatite Nanoparticles ◽  
Ph Responsive ◽  
Intracellular Drug Delivery

pH-Responsive Poly(styrene-alt-maleic anhydride) Alkylamide Copolymers for Intracellular Drug Delivery

2006 ◽  
Vol 7 (8) ◽  
pp. 2407-2414 ◽  
Author(s):  
Scott M. Henry ◽  
Mohamed E. H. El-Sayed ◽  
Christopher M. Pirie ◽  
Allan S. Hoffman ◽  
Patrick S. Stayton
Keyword(s):  
Drug Delivery ◽  
Maleic Anhydride ◽  
Ph Responsive ◽  
Intracellular Drug Delivery

Pillar[5]arene based supramolecular prodrug micelles with pH induced aggregate behavior for intracellular drug delivery

2015 ◽  
Vol 51 (14) ◽  
pp. 2999-3002 ◽  
Author(s):  
Yin Wang ◽  
Jianwei Du ◽  
Youxiang Wang ◽  
Qiao Jin ◽  
Jian Ji
Keyword(s):  
Drug Delivery ◽  
Acidic Condition ◽  
Ph Responsive ◽  
Intracellular Drug Delivery ◽  
Aggregate Behavior ◽  
Therapy Effect

A novel type of dual pH-responsive supramolecular prodrug micelles based on pillar[5]arene was prepared. It was found that the prodrug micelles could be aggregated upon acidic condition, which led to enhanced accumulation and better therapy effect.

Fluorescence resonance energy transfer monitoring of pH-responsive doxorubicin release from carbon dots/aptamer functionalized magnetic mesoporous silica

Nanomedicine ◽  
2021 ◽  
Author(s):  
Abolghasem Abbasi Kajani ◽  
Masoud Ayatollahi Mehrgardi
Keyword(s):  
Drug Delivery ◽  
Energy Transfer ◽  
Fluorescence Resonance Energy Transfer ◽  
Carbon Dots ◽  
Drug Loading ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Spectroscopic Techniques ◽  
Ph Responsive ◽  
Fluorescence Resonance

Aim: To develop a novel theranostic nanoplatform for simultaneous fluorescent monitoring and stimuli-triggered drug delivery. Materials & methods: Different microscopic and spectroscopic techniques were used for the characterization of nanocarriers. MCF-7 and human umbilical vein endothelial cell lines were cultured and treated with different doses of doxorubicin-loaded nanocarriers. The cell viability and drug release were studied using MTT assay and fluorescence microscopy. Results: Biocompatible and mono-disperse nanocarriers represent hollow and mesoporous structures with the calculated surface area of 552.83 m2.g-1, high magnetic activity (12.6 emu.g-1), appropriate colloidal stability and high drug loading capacity (up to 61%). Conclusion: Taxane-based carbon dots act as the pH-responsive gatekeepers for the controlled release of doxorubicin into cancer cells and provide a fluorescence resonance energy transfer system for real-time monitoring of drug delivery.

Magnetic particle anchored reduction and pH responsive nanogel for enhanced intracellular drug delivery

2020 ◽  
Vol 129 ◽  
pp. 109638 ◽  
Author(s):  
Pijush Mandal ◽  
Sudipta Panja ◽  
Sovan Lal Banerjee ◽  
Sanjoy Kumar Ghorai ◽  
Somnath Maji ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Particle ◽  
Ph Responsive ◽  
Intracellular Drug Delivery

pH-Responsive unimolecular micelles based on amphiphilic star-like copolymers with high drug loading for effective drug delivery and cellular imaging

2017 ◽  
Vol 5 (33) ◽  
pp. 6847-6859 ◽  
Author(s):  
Xiaoxiao Shi ◽  
Xiaoqian Ma ◽  
Meili Hou ◽  
Yong-E Gao ◽  
Shuang Bai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Cellular Imaging ◽  
Effective Drug ◽  
Ph Responsive ◽  
High Drug ◽  
Nir Imaging ◽  
High Drug Loading

A theranostic nanoplatform based on pH-responsive amphiphilic star-like copolymers for theranostic and NIR imaging applications.

scholarly journals Self-Propelling Targeted Magneto-Nanobots for Deep Tumor Penetration and pH-Responsive Intracellular Drug Delivery

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Saloni S. Andhari ◽  
Ravindra D. Wavhale ◽  
Kshama D. Dhobale ◽  
Bhausaheb V. Tawade ◽  
Govind P. Chate ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Responsive ◽  
Tumor Penetration ◽  
Intracellular Drug Delivery

High drug loading and pH-responsive targeted nanocarriers from alginate-modified SPIONs for anti-tumor chemotherapy

2016 ◽  
Vol 4 (12) ◽  
pp. 1802-1813 ◽  
Author(s):  
Na Peng ◽  
Bo Wu ◽  
Lei Wang ◽  
Weiyang He ◽  
Ziye Ai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Drug Loading ◽  
Magnetic Targeting ◽  
Ph Responsive ◽  
High Drug ◽  
High Drug Loading

Novel pH-responsive and magnetic-targeting nanocarriers with high drug loading content were developed for pH-triggered targeting drug delivery in tumor cells.

pH responsive supramolecular prodrug micelles based on cucurbit[8]uril for intracellular drug delivery

2014 ◽  
Vol 50 (66) ◽  
pp. 9390-9392 ◽  
Author(s):  
Yin Wang ◽  
Dandan Li ◽  
Haibo Wang ◽  
Yangjun Chen ◽  
Haijie Han ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Responsive ◽  
Intracellular Drug Delivery

Superparamagnetic yolk–shell porous nanospheres of iron oxide@magnesium silicate: synthesis and application in high-performance anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (105) ◽  
pp. 103399-103411 ◽  
Author(s):  
Tuan-Wei Sun ◽  
Ying-Jie Zhu ◽  
Feng Chen ◽  
Chao Qi ◽  
Bing-Qiang Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
High Performance ◽  
Drug Loading ◽  
Magnesium Silicate ◽  
Loading Capacity ◽  
Ph Responsive ◽  
High Drug ◽  
Anticancer Drug Delivery ◽  
High Drug Loading

The as-prepared yolk–shell porous nanospheres of SPIO@MS exhibit a high drug loading capacity, and a sustained and pH-responsive drug release behaviour.

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