pH-Responsive Poly(styrene-alt-maleic anhydride) Alkylamide Copolymers for Intracellular Drug Delivery

2006 ◽  
Vol 7 (8) ◽  
pp. 2407-2414 ◽  
Author(s):  
Scott M. Henry ◽  
Mohamed E. H. El-Sayed ◽  
Christopher M. Pirie ◽  
Allan S. Hoffman ◽  
Patrick S. Stayton
Keyword(s):  
Drug Delivery ◽  
Maleic Anhydride ◽  
Ph Responsive ◽  
Intracellular Drug Delivery

Pillar[5]arene based supramolecular prodrug micelles with pH induced aggregate behavior for intracellular drug delivery

2015 ◽  
Vol 51 (14) ◽  
pp. 2999-3002 ◽  
Author(s):  
Yin Wang ◽  
Jianwei Du ◽  
Youxiang Wang ◽  
Qiao Jin ◽  
Jian Ji
Keyword(s):  
Drug Delivery ◽  
Acidic Condition ◽  
Ph Responsive ◽  
Intracellular Drug Delivery ◽  
Aggregate Behavior ◽  
Therapy Effect

A novel type of dual pH-responsive supramolecular prodrug micelles based on pillar[5]arene was prepared. It was found that the prodrug micelles could be aggregated upon acidic condition, which led to enhanced accumulation and better therapy effect.

Magnetic particle anchored reduction and pH responsive nanogel for enhanced intracellular drug delivery

2020 ◽  
Vol 129 ◽  
pp. 109638 ◽  
Author(s):  
Pijush Mandal ◽  
Sudipta Panja ◽  
Sovan Lal Banerjee ◽  
Sanjoy Kumar Ghorai ◽  
Somnath Maji ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Particle ◽  
Ph Responsive ◽  
Intracellular Drug Delivery

scholarly journals Self-Propelling Targeted Magneto-Nanobots for Deep Tumor Penetration and pH-Responsive Intracellular Drug Delivery

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Saloni S. Andhari ◽  
Ravindra D. Wavhale ◽  
Kshama D. Dhobale ◽  
Bhausaheb V. Tawade ◽  
Govind P. Chate ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Responsive ◽  
Tumor Penetration ◽  
Intracellular Drug Delivery

pH responsive supramolecular prodrug micelles based on cucurbit[8]uril for intracellular drug delivery

2014 ◽  
Vol 50 (66) ◽  
pp. 9390-9392 ◽  
Author(s):  
Yin Wang ◽  
Dandan Li ◽  
Haibo Wang ◽  
Yangjun Chen ◽  
Haijie Han ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Responsive ◽  
Intracellular Drug Delivery

Light cross-linkable and pH de-cross-linkable drug nanocarriers for intracellular drug delivery

2015 ◽  
Vol 6 (11) ◽  
pp. 2069-2075 ◽  
Author(s):  
Fan Jia ◽  
Yin Wang ◽  
Haibo Wang ◽  
Qiao Jin ◽  
Tongjiang Cai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cross Linking ◽  
Ph Responsive ◽  
Intracellular Drug Delivery ◽  
Drug Nanocarriers

Novel light cross-linkable and pH de-cross-linkable micelles were developed as drug nanocarriers, based on the combination of light responsive coumarin moieties and pH responsive hydrazone groups in one cross-linking section.

Biomembrane-Active Molecular Switches as Tools for Intracellular Drug Delivery

2005 ◽  
Vol 58 (6) ◽  
pp. 411 ◽  
Author(s):  
Volga Bulmus
Keyword(s):  
Drug Delivery ◽  
Vaccine Development ◽  
Molecular Switches ◽  
Synthetic Polymers ◽  
Ph Responsive ◽  
Cellular Membranes ◽  
Therapeutic Concentration ◽  
Transport Barrier ◽  
Intracellular Drug Delivery ◽  
Biological Organisms

Many therapeutic strategies, such as gene therapy and vaccine development require the delivery of polar macromolecules (e.g. DNA, RNA, and proteins) to intracellular sites at a therapeutic concentration. For such macromolecular therapeutics, cellular membranes constitute a major transport barrier that must be overcome before these drugs can exert their biological activity inside cells. A number of biological organisms, e.g. viruses and toxins, efficiently destabilize the cellular membranes upon a trigger, such as low pH, and facilitate the delivery of their biological cargo to the cytoplasm of host cell. pH-responsive synthetic peptides and polymers have been designed to mimic the function of membrane-destabilizing natural organisms and evaluated as a part of drug delivery systems. In this Review, pH-dependent membrane activity of natural and synthetic systems is reviewed, focussing on fundamental and practical aspects of pH-responsive, membrane-disruptive synthetic polymers in intracellular drug delivery.

scholarly journals Nanoparticles incorporating pH-responsive surfactants as a viable approach to improve the intracellular drug delivery

2015 ◽  
Vol 57 ◽  
pp. 100-106 ◽  
Author(s):  
Daniele R. Nogueira ◽  
Laís E. Scheeren ◽  
M. Pilar Vinardell ◽  
Montserrat Mitjans ◽  
M. Rosa Infante ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Responsive ◽  
Intracellular Drug Delivery ◽  
Viable Approach

A pH-responsive drug delivery system with an aggregation-induced emission feature for cell imaging and intracellular drug delivery

2015 ◽  
Vol 6 (26) ◽  
pp. 4715-4718 ◽  
Author(s):  
Haibo Wang ◽  
Gongyan Liu ◽  
Haiqi Gao ◽  
Yunbing Wang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cell Imaging ◽  
Emission Feature ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Therapeutic Treatment ◽  
Aggregation Induced Emission ◽  
Intracellular Drug Delivery

A pH-sensitive fluorescent vehicle based on aggregation-induced emission (AIE) has been developed as a drug delivery system for simultaneous cell imaging and therapeutic treatment.

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