High drug loading and pH-responsive targeted nanocarriers from alginate-modified SPIONs for anti-tumor chemotherapy

2016 ◽  
Vol 4 (12) ◽  
pp. 1802-1813 ◽  
Author(s):  
Na Peng ◽  
Bo Wu ◽  
Lei Wang ◽  
Weiyang He ◽  
Ziye Ai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Drug Loading ◽  
Magnetic Targeting ◽  
Ph Responsive ◽  
High Drug ◽  
High Drug Loading

Novel pH-responsive and magnetic-targeting nanocarriers with high drug loading content were developed for pH-triggered targeting drug delivery in tumor cells.

pH-Responsive unimolecular micelles based on amphiphilic star-like copolymers with high drug loading for effective drug delivery and cellular imaging

2017 ◽  
Vol 5 (33) ◽  
pp. 6847-6859 ◽  
Author(s):  
Xiaoxiao Shi ◽  
Xiaoqian Ma ◽  
Meili Hou ◽  
Yong-E Gao ◽  
Shuang Bai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Cellular Imaging ◽  
Effective Drug ◽  
Ph Responsive ◽  
High Drug ◽  
Nir Imaging ◽  
High Drug Loading

A theranostic nanoplatform based on pH-responsive amphiphilic star-like copolymers for theranostic and NIR imaging applications.

Superparamagnetic yolk–shell porous nanospheres of iron oxide@magnesium silicate: synthesis and application in high-performance anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (105) ◽  
pp. 103399-103411 ◽  
Author(s):  
Tuan-Wei Sun ◽  
Ying-Jie Zhu ◽  
Feng Chen ◽  
Chao Qi ◽  
Bing-Qiang Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
High Performance ◽  
Drug Loading ◽  
Magnesium Silicate ◽  
Loading Capacity ◽  
Ph Responsive ◽  
High Drug ◽  
Anticancer Drug Delivery ◽  
High Drug Loading

The as-prepared yolk–shell porous nanospheres of SPIO@MS exhibit a high drug loading capacity, and a sustained and pH-responsive drug release behaviour.

Combination therapeutics of doxorubicin with Fe3O4@chitosan@phytic acid nanoparticles for multi-responsive drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (91) ◽  
pp. 88248-88254 ◽  
Author(s):  
Dandan Xu ◽  
Rui Xie ◽  
Tongying Xu ◽  
Xuejie Guo ◽  
Qi Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Phytic Acid ◽  
Drug Loading ◽  
Magnetic Saturation ◽  
High Drug ◽  
Ph Response ◽  
Loading Efficiency ◽  
Drug Loading Efficiency ◽  
High Drug Loading

Fe3O4@CS nanoparticles as the precursors were encapsulated by PA, developing Fe3O4@CS@PA nanocarriers with high drug loading efficiency, outstanding magnetic saturation, remarkable pH-response and obvious inhibition to tumor cells.

scholarly journals Schiff-Linked PEGylated Doxorubicin Prodrug Forming pH-Responsive Nanoparticles With High Drug Loading and Effective Anticancer Therapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Jian Song ◽  
Bingbing Xu ◽  
Hui Yao ◽  
Xiaofang Lu ◽  
Yang Tan ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Cells ◽  
Drug Loading ◽  
Drug Carriers ◽  
Anticancer Therapy ◽  
Therapeutic Effects ◽  
Ph Responsive ◽  
High Drug ◽  
High Drug Loading ◽  
Mcf 7

Developing efficacious drug delivery systems for targeted cancer chemotherapy remains a major challenge. Here we demonstrated a kind of pH-responsive PEGylated doxorubicin (DOX) prodrug via the effective esterification and Schiff base reactions, which could self-assemble into the biodegradable micelles in aqueous solutions. Owing to low pH values inside the tumor cells, these PEG-Schiff-DOX nanoparticles exhibited high drug loading ability and pH-responsive drug release behavior within the tumor cells or tissues upon changes in physical and chemical environments, but they displayed good stability at physiological conditions for a long period. CCK-8 assay showed that these PEGylated DOX prodrugs had a similar cytotoxicity to the MCF-7 tumor cells as the free DOX drug. Moreover, this kind of nanoparticle could also encapsulate small DOX drugs with high drug loading, sufficient drug release and enhanced therapeutic effects toward MCF-7 cells, which will be benefited for developing more drug carriers with desirable functions for clinical anticancer therapy.

Prodrugs Forming High Drug Loading Multifunctional Nanocapsules for Intracellular Cancer Drug Delivery

2010 ◽  
Vol 132 (12) ◽  
pp. 4259-4265 ◽  
Author(s):  
Youqing Shen ◽  
Erlei Jin ◽  
Bo Zhang ◽  
Caitlin J. Murphy ◽  
Meihua Sui ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Cancer Drug ◽  
High Drug ◽  
Cancer Drug Delivery ◽  
High Drug Loading

A novel high drug loading mussel-inspired polydopamine hybrid nanoparticle as a pH-sensitive vehicle for drug delivery

2017 ◽  
Vol 533 (1) ◽  
pp. 73-83 ◽  
Author(s):  
Jie Hou ◽  
Chunlei Guo ◽  
Yuzhi Shi ◽  
Ergang Liu ◽  
Weibing Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Ph Sensitive ◽  
High Drug ◽  
Hybrid Nanoparticle ◽  
High Drug Loading

scholarly journals A facile doxorubicin-dichloroacetate conjugate nanomedicine with high drug loading for safe drug delivery

2018 ◽  
Vol Volume 13 ◽  
pp. 1281-1293 ◽  
Author(s):  
Conglian Yang ◽  
Tingting Wu ◽  
Yuting Qin ◽  
Yan Qi ◽  
Yu Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
High Drug ◽  
High Drug Loading

A γ-cyclodextrin-based metal–organic framework embedded with graphene quantum dots and modified with PEGMA via SI-ATRP for anticancer drug delivery and therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (43) ◽  
pp. 20956-20967 ◽  
Author(s):  
Qiaojuan Jia ◽  
Zhenzhen Li ◽  
Chuanpan Guo ◽  
Xiaoyu Huang ◽  
Yingpan Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Graphene Quantum Dots ◽  
Tumor Growth Inhibition ◽  
High Drug ◽  
Anticancer Drug Delivery ◽  
Metal Organic ◽  
High Drug Loading

A biocompatible γ-CD-MOF based DDS with high drug loading and full drug release was prepared and effective tumor growth inhibition was achieved in vivo.

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