Pillar[5]arene based supramolecular prodrug micelles with pH induced aggregate behavior for intracellular drug delivery

2015 ◽  
Vol 51 (14) ◽  
pp. 2999-3002 ◽  
Author(s):  
Yin Wang ◽  
Jianwei Du ◽  
Youxiang Wang ◽  
Qiao Jin ◽  
Jian Ji
Keyword(s):  
Drug Delivery ◽  
Acidic Condition ◽  
Ph Responsive ◽  
Intracellular Drug Delivery ◽  
Aggregate Behavior ◽  
Therapy Effect

A novel type of dual pH-responsive supramolecular prodrug micelles based on pillar[5]arene was prepared. It was found that the prodrug micelles could be aggregated upon acidic condition, which led to enhanced accumulation and better therapy effect.

pH-Responsive Poly(styrene-alt-maleic anhydride) Alkylamide Copolymers for Intracellular Drug Delivery

2006 ◽  
Vol 7 (8) ◽  
pp. 2407-2414 ◽  
Author(s):  
Scott M. Henry ◽  
Mohamed E. H. El-Sayed ◽  
Christopher M. Pirie ◽  
Allan S. Hoffman ◽  
Patrick S. Stayton
Keyword(s):  
Drug Delivery ◽  
Maleic Anhydride ◽  
Ph Responsive ◽  
Intracellular Drug Delivery

Magnetic particle anchored reduction and pH responsive nanogel for enhanced intracellular drug delivery

2020 ◽  
Vol 129 ◽  
pp. 109638 ◽  
Author(s):  
Pijush Mandal ◽  
Sudipta Panja ◽  
Sovan Lal Banerjee ◽  
Sanjoy Kumar Ghorai ◽  
Somnath Maji ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Particle ◽  
Ph Responsive ◽  
Intracellular Drug Delivery

scholarly journals Self-Propelling Targeted Magneto-Nanobots for Deep Tumor Penetration and pH-Responsive Intracellular Drug Delivery

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Saloni S. Andhari ◽  
Ravindra D. Wavhale ◽  
Kshama D. Dhobale ◽  
Bhausaheb V. Tawade ◽  
Govind P. Chate ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Responsive ◽  
Tumor Penetration ◽  
Intracellular Drug Delivery

pH responsive supramolecular prodrug micelles based on cucurbit[8]uril for intracellular drug delivery

2014 ◽  
Vol 50 (66) ◽  
pp. 9390-9392 ◽  
Author(s):  
Yin Wang ◽  
Dandan Li ◽  
Haibo Wang ◽  
Yangjun Chen ◽  
Haijie Han ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Responsive ◽  
Intracellular Drug Delivery

Light cross-linkable and pH de-cross-linkable drug nanocarriers for intracellular drug delivery

2015 ◽  
Vol 6 (11) ◽  
pp. 2069-2075 ◽  
Author(s):  
Fan Jia ◽  
Yin Wang ◽  
Haibo Wang ◽  
Qiao Jin ◽  
Tongjiang Cai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cross Linking ◽  
Ph Responsive ◽  
Intracellular Drug Delivery ◽  
Drug Nanocarriers

Novel light cross-linkable and pH de-cross-linkable micelles were developed as drug nanocarriers, based on the combination of light responsive coumarin moieties and pH responsive hydrazone groups in one cross-linking section.

Biomembrane-Active Molecular Switches as Tools for Intracellular Drug Delivery

2005 ◽  
Vol 58 (6) ◽  
pp. 411 ◽  
Author(s):  
Volga Bulmus
Keyword(s):  
Drug Delivery ◽  
Vaccine Development ◽  
Molecular Switches ◽  
Synthetic Polymers ◽  
Ph Responsive ◽  
Cellular Membranes ◽  
Therapeutic Concentration ◽  
Transport Barrier ◽  
Intracellular Drug Delivery ◽  
Biological Organisms

Many therapeutic strategies, such as gene therapy and vaccine development require the delivery of polar macromolecules (e.g. DNA, RNA, and proteins) to intracellular sites at a therapeutic concentration. For such macromolecular therapeutics, cellular membranes constitute a major transport barrier that must be overcome before these drugs can exert their biological activity inside cells. A number of biological organisms, e.g. viruses and toxins, efficiently destabilize the cellular membranes upon a trigger, such as low pH, and facilitate the delivery of their biological cargo to the cytoplasm of host cell. pH-responsive synthetic peptides and polymers have been designed to mimic the function of membrane-destabilizing natural organisms and evaluated as a part of drug delivery systems. In this Review, pH-dependent membrane activity of natural and synthetic systems is reviewed, focussing on fundamental and practical aspects of pH-responsive, membrane-disruptive synthetic polymers in intracellular drug delivery.

scholarly journals Nanoparticles incorporating pH-responsive surfactants as a viable approach to improve the intracellular drug delivery

2015 ◽  
Vol 57 ◽  
pp. 100-106 ◽  
Author(s):  
Daniele R. Nogueira ◽  
Laís E. Scheeren ◽  
M. Pilar Vinardell ◽  
Montserrat Mitjans ◽  
M. Rosa Infante ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Responsive ◽  
Intracellular Drug Delivery ◽  
Viable Approach

A pH-responsive drug delivery system with an aggregation-induced emission feature for cell imaging and intracellular drug delivery

2015 ◽  
Vol 6 (26) ◽  
pp. 4715-4718 ◽  
Author(s):  
Haibo Wang ◽  
Gongyan Liu ◽  
Haiqi Gao ◽  
Yunbing Wang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cell Imaging ◽  
Emission Feature ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Therapeutic Treatment ◽  
Aggregation Induced Emission ◽  
Intracellular Drug Delivery

A pH-sensitive fluorescent vehicle based on aggregation-induced emission (AIE) has been developed as a drug delivery system for simultaneous cell imaging and therapeutic treatment.

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