Dynamic development of the protein corona on silica nanoparticles: composition and role in toxicity

Nanoscale ◽  
2013 ◽  
Vol 5 (14) ◽  
pp. 6372 ◽  
Author(s):  
Ninell P. Mortensen ◽  
Gregory B. Hurst ◽  
Wei Wang ◽  
Carmen M. Foster ◽  
Prakash D. Nallathamby ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Protein Corona ◽  
Dynamic Development

Toxicity and mechanism of mesoporous silica nanoparticles in eyes

Nanoscale ◽  
2020 ◽  
Vol 12 (25) ◽  
pp. 13637-13653 ◽  
Author(s):  
Xia Chen ◽  
Shuang Zhu ◽  
Xisu Hu ◽  
Dayu Sun ◽  
Junling Yang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Dry Eye ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Large Surface Area ◽  
Corneal Damage

It aims to explore the toxicity and mechanism of large-surface-area MSiNPs and MSiNPs-Ag+ exposed to hCEC cells and cornea. A protein corona-based therapy was proposed to treat MSiNPs and MSiNPs-Ag+ induced corneal damage and dry eye.

Magnetite mesoporous silica nanoparticles embedded in carboxybetaine methacrylate for application in hyperthermia and drug delivery

2020 ◽  
Vol 44 (20) ◽  
pp. 8232-8240 ◽  
Author(s):  
Hasan Keshavarz ◽  
Alireza Khavandi ◽  
Somaye Alamolhoda ◽  
M. Reza Naimi-Jamal
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Target Tissue ◽  
Burst Effect

Magnetite mesoporous silica nanoparticles (MMSNs) are biocompatible and can easily deliver a drug to the target tissue, but there are two challenges: burst effect and protein corona.

scholarly journals Interactions between functionalised silica nanoparticles and Pseudomonas fluorescens biofilm matrix: A focus on the protein corona

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0236441
Author(s):  
Caio H. N. Barros ◽  
Stephanie Fulaz ◽  
Stefania Vitale ◽  
Eoin Casey ◽  
Laura Quinn
Keyword(s):  
Silica Nanoparticles ◽  
Pseudomonas Fluorescens ◽  
Protein Corona ◽  
Biofilm Matrix

Serum apolipoprotein A-I depletion is causative to silica nanoparticles–induced cardiovascular damage

2021 ◽  
Vol 118 (44) ◽  
pp. e2108131118
Author(s):  
Xuting Liu ◽  
Wei Wei ◽  
Zixuan Liu ◽  
Erqun Song ◽  
Jianlin Lou ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Silica Nanoparticles ◽  
Rapid Development ◽  
Atherosclerotic Lesion ◽  
Modern Science ◽  
Protein Corona ◽  
Systemic Circulation ◽  
Cardiovascular Damage ◽  
Apolipoprotein A ◽  
Mimic Peptide

The rapid development of nanotechnology has greatly benefited modern science and engineering and also led to an increased environmental exposure to nanoparticles (NPs). While recent research has established a correlation between the exposure of NPs and cardiovascular diseases, the intrinsic mechanisms of such a connection remain unclear. Inhaled NPs can penetrate the air–blood barrier from the lung to systemic circulation, thereby intruding the cardiovascular system and generating cardiotoxic effects. In this study, on-site cardiovascular damage was observed in mice upon respiratory exposure of silica nanoparticles (SiNPs), and the corresponding mechanism was investigated by focusing on the interaction of SiNPs and their encountered biomacromolecules en route. SiNPs were found to collect a significant amount of apolipoprotein A-I (Apo A-I) from the blood, in particular when the SiNPs were preadsorbed with pulmonary surfactants. While the adsorbed Apo A-I ameliorated the cytotoxic and proinflammatory effects of SiNPs, the protein was eliminated from the blood upon clearance of the NPs. However, supplementation of Apo A-I mimic peptide mitigated the atherosclerotic lesion induced by SiNPs. In addition, we found a further declined plasma Apo A-I level in clinical silicosis patients than coronary heart disease patients, suggesting clearance of SiNPs sequestered Apo A-I to compromise the coronal protein’s regular biological functions. Together, this study has provided evidence that the protein corona of SiNPs acquired in the blood depletes Apo A-I, a biomarker for prediction of cardiovascular diseases, which gives rise to unexpected toxic effects of the nanoparticles.

scholarly journals Effect of surface properties in protein corona development on mesoporous silica nanoparticles

RSC Advances ◽  
2014 ◽  
Vol 4 (55) ◽  
pp. 29134-29138 ◽  
Author(s):  
Alden M. Clemments ◽  
Carlos Muniesa ◽  
Christopher C. Landry ◽  
Pablo Botella
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Properties ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Surface Modifications ◽  
Effect Of Surface

The composition of the protein corona formed on mesoporous silica nanoparticles with several surface modifications was characterized.

scholarly journals Protein Corona Composition of Silica Nanoparticles in Complex Media: Nanoparticle Size does not Matter

Nanomaterials ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 240 ◽  
Author(s):  
Laurent Marichal ◽  
Géraldine Klein ◽  
Jean Armengaud ◽  
Yves Boulard ◽  
Stéphane Chédin ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Electrostatic Interactions ◽  
Large Scale ◽  
Driving Forces ◽  
Protein Corona ◽  
Sequence Length ◽  
Label Free ◽  
Curvature Effects ◽  
Proteomic Approach ◽  
Adsorbed Proteins

Biomolecules, and particularly proteins, bind on nanoparticle (NP) surfaces to form the so-called protein corona. It is accepted that the corona drives the biological distribution and toxicity of NPs. Here, the corona composition and structure were studied using silica nanoparticles (SiNPs) of different sizes interacting with soluble yeast protein extracts. Adsorption isotherms showed that the amount of adsorbed proteins varied greatly upon NP size with large NPs having more adsorbed proteins per surface unit. The protein corona composition was studied using a large-scale label-free proteomic approach, combined with statistical and regression analyses. Most of the proteins adsorbed on the NPs were the same, regardless of the size of the NPs. To go beyond, the protein physicochemical parameters relevant for the adsorption were studied: electrostatic interactions and disordered regions are the main driving forces for the adsorption on SiNPs but polypeptide sequence length seems to be an important factor as well. This article demonstrates that curvature effects exhibited using model proteins are not determining factors for the corona composition on SiNPs, when dealing with complex biological media.

scholarly journals Suppression of the hemolytic effect of mesoporous silica nanoparticles after protein corona interaction: independence of the surface microchemical environment

2012 ◽  
Vol 23 (10) ◽  
pp. 1807-1814 ◽  
Author(s):  
Amauri J. Paula ◽  
Diego Stéfani T. Martinez ◽  
Roberto T. Araujo Júnior ◽  
Antonio G. Souza Filho ◽  
Oswaldo L. Alves
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Hemolytic Effect

Utilizing the protein corona around silica nanoparticles for dual drug loading and release

Nanoscale ◽  
2015 ◽  
Vol 7 (39) ◽  
pp. 16251-16265 ◽  
Author(s):  
Shakiba Shahabi ◽  
Laura Treccani ◽  
Ralf Dringen ◽  
Kurosch Rezwan
Keyword(s):  
Silica Nanoparticles ◽  
Drug Loading ◽  
Protein Corona ◽  
Multiple Drugs ◽  
Dual Drug

The protein corona, which forms spontaneously around silica nanoparticles in serum-containing media, can be exploited for delivery of multiple drugs.

Influence of Protein Corona on the Transport of Molecules into Cells by Mesoporous Silica Nanoparticles

2013 ◽  
Vol 5 (17) ◽  
pp. 8387-8393 ◽  
Author(s):  
Amauri J. Paula ◽  
Roberto T. Araujo Júnior ◽  
Diego Stéfani T. Martinez ◽  
Edgar J. Paredes-Gamero ◽  
Helena B. Nader ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona

Monitoring the Hemolytic Effect of Mesoporous Silica Nanoparticles after Human Blood Protein Corona Formation

2015 ◽  
Vol 2015 (27) ◽  
pp. 4595-4602 ◽  
Author(s):  
Diego Stéfani T. Martinez ◽  
Amauri J. Paula ◽  
Leandro C. Fonseca ◽  
Luis Augusto V. Luna ◽  
Camila P. Silveira ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Human Blood ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Blood Protein ◽  
Corona Formation ◽  
Hemolytic Effect
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