Toxicity and mechanism of mesoporous silica nanoparticles in eyes

Nanoscale ◽  
2020 ◽  
Vol 12 (25) ◽  
pp. 13637-13653 ◽  
Author(s):  
Xia Chen ◽  
Shuang Zhu ◽  
Xisu Hu ◽  
Dayu Sun ◽  
Junling Yang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Dry Eye ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Large Surface Area ◽  
Corneal Damage

It aims to explore the toxicity and mechanism of large-surface-area MSiNPs and MSiNPs-Ag+ exposed to hCEC cells and cornea. A protein corona-based therapy was proposed to treat MSiNPs and MSiNPs-Ag+ induced corneal damage and dry eye.

Hierarchical mesoporous silica nanoparticles as superb light scattering materials

2016 ◽  
Vol 52 (10) ◽  
pp. 2165-2168 ◽  
Author(s):  
Jaehoon Ryu ◽  
Juyoung Yun ◽  
Jungsup Lee ◽  
Kisu Lee ◽  
Jyongsik Jang
Keyword(s):  
Light Scattering ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Multiple Scattering ◽  
Mesoporous Silica Nanoparticles ◽  
Large Surface Area ◽  
Scattering Effect ◽  
Novel Approach ◽  
Light Scattering Effect

A novel approach to enhance the light scattering effect was explored by applying hierarchical mesoporous silica nanoparticles with a radial wrinkle structure (WSNs) in DSSCs as scattering layers. The WSNs were evaluated as outstanding light scattering materials providing large surface area as well as multiple scattering.

Magnetite mesoporous silica nanoparticles embedded in carboxybetaine methacrylate for application in hyperthermia and drug delivery

2020 ◽  
Vol 44 (20) ◽  
pp. 8232-8240 ◽  
Author(s):  
Hasan Keshavarz ◽  
Alireza Khavandi ◽  
Somaye Alamolhoda ◽  
M. Reza Naimi-Jamal
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Target Tissue ◽  
Burst Effect

Magnetite mesoporous silica nanoparticles (MMSNs) are biocompatible and can easily deliver a drug to the target tissue, but there are two challenges: burst effect and protein corona.

scholarly journals Hyper-Crosslinked Polymer Nanocomposites Containing Mesoporous Silica Nanoparticles with Enhanced Adsorption Towards Polar Dyes

Polymers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1388
Author(s):  
Marco Guerritore ◽  
Rachele Castaldo ◽  
Brigida Silvestri ◽  
Roberto Avolio ◽  
Mariacristina Cocca ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Organic Dyes ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
High Surface Area ◽  
Reactive Dye ◽  
New Strategy ◽  
Enhanced Adsorption

The development of new styrene-based hyper-crosslinked nanocomposites (HCLN) containing mesoporous silica nanoparticles (MSN) is reported here as a new strategy to obtain functional high surface area materials with an enhanced hydrophilic character. The HCLN composition, morphology and porous structure were analyzed using a multi-technique approach. The HCLN displayed a high surface area (above 1600 m2/g) and higher microporosity than the corresponding hyper-crosslinked neat resin. The enhanced adsorption properties of the HCLN towards polar organic dyes was demonstrated through the adsorption of a reactive dye, Remazol Brilliant Blue R (RB). In particular, the HCLN containing 5phr MSN showed the highest adsorption capacity of RB.

Synthesis of Mesoporous Silica Nanoparticles for Drug Delivery

2014 ◽  
Vol 602-603 ◽  
pp. 67-70
Author(s):  
Ya Zhen Wu ◽  
Xiao Yun Jia ◽  
Yuan Hua Lin ◽  
De Ping Liu
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Mesoporous Silica Nanoparticles ◽  
Close Correlation ◽  
Release Kinetic ◽  
Incipient Wetness Impregnation ◽  
Drug Delivery Carrier

Mesoporous silica nanoparticles (MSNs) is an attractive candidate as a drug delivery carrier due to their large surface area, high pore volume and t intrinsic biocompatibility. Here, MSNs were synthesized by the hydrolysis and condensation of tetraethyl orthosilicate (TEOS) with cetyltrimethylammonium bromide (CTAB) acting as structural directing agent. A large mesopore with diameter of 3.8 to 5.5 nm of MCM-41style can be obtained via the addition of 1,3,5-trimethylbenzene. Metoprolol tartrate as a selective β1 receptor blocker was embedded on MSNs by the incipient wetness impregnation. The delivery profiles were collected in vitro in SBF at pH 7.4. A close correlation can be observed between the drug release kinetic and the mesopore size and specific surface area of MSNs.

scholarly journals Effect of surface properties in protein corona development on mesoporous silica nanoparticles

RSC Advances ◽  
2014 ◽  
Vol 4 (55) ◽  
pp. 29134-29138 ◽  
Author(s):  
Alden M. Clemments ◽  
Carlos Muniesa ◽  
Christopher C. Landry ◽  
Pablo Botella
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Properties ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Surface Modifications ◽  
Effect Of Surface

The composition of the protein corona formed on mesoporous silica nanoparticles with several surface modifications was characterized.

scholarly journals Biphenyl Wrinkled Mesoporous Silica Nanoparticles for pH-Responsive Doxorubicin Drug Delivery

Materials ◽  
2020 ◽  
Vol 13 (8) ◽  
pp. 1998 ◽  
Author(s):  
Jason Lin ◽  
Chuanqi Peng ◽  
Sanjana Ravi ◽  
A. K. M. Nur Alam Siddiki ◽  
Jie Zheng ◽  
...  
Keyword(s):  
Particle Size ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
High Surface ◽  
Average Particle Size ◽  
Average Particle ◽  
Mcf 7

Biphenyl wrinkled mesoporous silica nanoparticles with controlled particle size and high surface area were evaluated for the storage and delivery of doxorubicin. The average particle size and surface area were ~70 nm and ~1100 m2/g. The doxorubicin loading efficiency was 38.2 ± 1.5 (w/w)% and the release was pH dependent. The breast cancer cell line, MCF-7 (Michigan Cancer Foundation-7) was used for the in vitro drug release study. The cytotoxicity of doxorubicin-loaded nanoparticles was significantly higher than free doxorubicin. Fluorescence images showed biphenyl wrinkled mesoporous silica (BPWS) uptake by the MCF-7 cells. The biphenyl bridged wrinkled silica nanoparticles appear promising for hydrophobic drug loading and delivery.

scholarly journals Suppression of the hemolytic effect of mesoporous silica nanoparticles after protein corona interaction: independence of the surface microchemical environment

2012 ◽  
Vol 23 (10) ◽  
pp. 1807-1814 ◽  
Author(s):  
Amauri J. Paula ◽  
Diego Stéfani T. Martinez ◽  
Roberto T. Araujo Júnior ◽  
Antonio G. Souza Filho ◽  
Oswaldo L. Alves
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Hemolytic Effect

Aminated mesoporous silica nanoparticles for the removal of low-concentration malodorous aldehyde gases

2018 ◽  
Vol 5 (11) ◽  
pp. 2663-2671 ◽  
Author(s):  
Shengpan Peng ◽  
Yuzhou Deng ◽  
Weiman Li ◽  
Jiayuan Chen ◽  
Haidi Liu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Mesoporous Silica Nanoparticles ◽  
Low Concentration ◽  
Functionalized Mesoporous Silica ◽  
Effective Removal ◽  
New Strategy

A new strategy of preparing functionalized mesoporous silica nanoparticles without sacrificing their surface area for the effective removal of low-concentration malodorous aldehyde gases.

Fabrication of Chitosan-coated Mesoporous Silica Nanoparticles Bearing Rosuvastatin as Drug Delivery System

2021 ◽  
Vol 18 ◽  
Author(s):  
Mojdeh Rahnama Ghahfarokhi ◽  
Ghasem Dini ◽  
Behrooz Movahedi
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Specific Surface ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Specific Surface Area ◽  
Ph Value ◽  
Mesoporous Silica Nanoparticles ◽  
Molar Ratio

Aim: In this work, to improve the solubility and bioavailability of the rosuvastatin (RSV) drug, chitosan-coated mesoporous silica nanoparticles (CS-MSNs) as drug delivery systems were fabricated. Methods: To do this, first MSNs with a maximum specific surface area were synthesized from sodium silicate as silica source and different molar ratios of cethyl trimethylammonium bromide (CTAB) and pluronics (P123, PEO20PPO17PEO20) as surfactants via the sol-gel process. Then, the synthesized MSNs were coated by CS polymer with the help of (3-glycidoxypropyl)methyldiethoxysilane (GPTMS) as a linker between MSNs and CS. Subsequently, the RSV drug was loaded into the synthesized CS-coated MSNs. The products were characterized by different techniques, including X-ray diffraction (XRD), the Brunauer-Emmett-Teller (BET), scanning electron microscopy (SEM), dynamic light scattering (DLS), and Fourier-transform infrared spectroscopy (FTIR). The in vitro drug release profile of the fabricated DDS was evaluated in a typical phosphate-buffered saline (PBS) solution at different pH values (i.e., 4, 6, and 7.4) for 48 h. To assess the cytotoxicity, the viability of the human fibroblast cells exposed to the fabricated DDS was also examined. Results: The results showed that at an optimal molar ratio of P123/CTAB, the amorphous MSNs with a specific surface area of about 1080 m2/g, a pore diameter of 4 nm, a pore volume of 1.1 cm3/g, and an average size of about 30 nm were synthesized. Also, the presence of all the components, including the CS coating and the RSV drug, was confirmed in the structure of the fabricated DDS by FTIR analysis. Due to the pH-responsive feature of the CS coating, the RSV drug release from the fabricated DDS showed a reasonable environmental response; as the pH value of the PBS solution decreased, the degree of drug release increased. Conclusion: The CS coating enhanced the cytotoxicity of the fabricated DDS and led to sustainable drug release behavior, which would provide a beneficial approach for drug delivery technology.

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