Monitoring the Hemolytic Effect of Mesoporous Silica Nanoparticles after Human Blood Protein Corona Formation

2015 ◽  
Vol 2015 (27) ◽  
pp. 4595-4602 ◽  
Author(s):  
Diego Stéfani T. Martinez ◽  
Amauri J. Paula ◽  
Leandro C. Fonseca ◽  
Luis Augusto V. Luna ◽  
Camila P. Silveira ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Human Blood ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Blood Protein ◽  
Corona Formation ◽  
Hemolytic Effect

scholarly journals Suppression of the hemolytic effect of mesoporous silica nanoparticles after protein corona interaction: independence of the surface microchemical environment

2012 ◽  
Vol 23 (10) ◽  
pp. 1807-1814 ◽  
Author(s):  
Amauri J. Paula ◽  
Diego Stéfani T. Martinez ◽  
Roberto T. Araujo Júnior ◽  
Antonio G. Souza Filho ◽  
Oswaldo L. Alves
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Hemolytic Effect

Toxicity and mechanism of mesoporous silica nanoparticles in eyes

Nanoscale ◽  
2020 ◽  
Vol 12 (25) ◽  
pp. 13637-13653 ◽  
Author(s):  
Xia Chen ◽  
Shuang Zhu ◽  
Xisu Hu ◽  
Dayu Sun ◽  
Junling Yang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Dry Eye ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Large Surface Area ◽  
Corneal Damage

It aims to explore the toxicity and mechanism of large-surface-area MSiNPs and MSiNPs-Ag+ exposed to hCEC cells and cornea. A protein corona-based therapy was proposed to treat MSiNPs and MSiNPs-Ag+ induced corneal damage and dry eye.

Magnetite mesoporous silica nanoparticles embedded in carboxybetaine methacrylate for application in hyperthermia and drug delivery

2020 ◽  
Vol 44 (20) ◽  
pp. 8232-8240 ◽  
Author(s):  
Hasan Keshavarz ◽  
Alireza Khavandi ◽  
Somaye Alamolhoda ◽  
M. Reza Naimi-Jamal
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Target Tissue ◽  
Burst Effect

Magnetite mesoporous silica nanoparticles (MMSNs) are biocompatible and can easily deliver a drug to the target tissue, but there are two challenges: burst effect and protein corona.

scholarly journals Biosafety of Mesoporous Silica Nanoparticles

Biomimetics ◽  
2018 ◽  
Vol 3 (3) ◽  
pp. 22 ◽  
Author(s):  
Estelle Rascol ◽  
Cédric Pisani ◽  
Christophe Dorandeu ◽  
Jeff Nyalosaso ◽  
Clarence Charnay ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Biological Fluids ◽  
Mesoporous Silica Nanoparticles ◽  
Careful Analysis ◽  
Extensive Study ◽  
Rigorous Testing ◽  
Corona Formation ◽  
Mechanism Of Interaction

Careful analysis of any new nanomedicine device or disposal should be undertaken to comprehensively characterize the new product before application, so that any unintended side effect is minimized. Because of the increasing number of nanotechnology-based drugs, we can anticipate that regulatory authorities might adapt the approval process for nanomedicine products due to safety concerns, e.g., request a more rigorous testing of the potential toxicity of nanoparticles (NPs). Currently, the use of mesoporous silica nanoparticles (MSN) as drug delivery systems is challenged by a lack of data on the toxicological profile of coated or non-coated MSN. In this context, we have carried out an extensive study documenting the influence of different functionalized MSN on the cellular internalization and in vivo behaviour. In this article, a synthesis of these works is reviewed and the perspectives are drawn. The use of magnetic MSN (Fe3O4@MSN) allows an efficient separation of coated NPs from cell cultures with a simple magnet, leading to results regarding corona formation without experimental bias. Our interest is focused on the mechanism of interaction with model membranes, the adsorption of proteins in biological fluids, the quantification of uptake, and the effect of such NPs on the transcriptomic profile of hepatic cells that are known to be readily concerned by NPs’ uptake in vivo, especially in the case of an intravenous injection.

scholarly journals Effect of surface properties in protein corona development on mesoporous silica nanoparticles

RSC Advances ◽  
2014 ◽  
Vol 4 (55) ◽  
pp. 29134-29138 ◽  
Author(s):  
Alden M. Clemments ◽  
Carlos Muniesa ◽  
Christopher C. Landry ◽  
Pablo Botella
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Properties ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Surface Modifications ◽  
Effect Of Surface

The composition of the protein corona formed on mesoporous silica nanoparticles with several surface modifications was characterized.

Influence of Protein Corona on the Transport of Molecules into Cells by Mesoporous Silica Nanoparticles

2013 ◽  
Vol 5 (17) ◽  
pp. 8387-8393 ◽  
Author(s):  
Amauri J. Paula ◽  
Roberto T. Araujo Júnior ◽  
Diego Stéfani T. Martinez ◽  
Edgar J. Paredes-Gamero ◽  
Helena B. Nader ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona

scholarly journals Protein Corona over Mesoporous Silica Nanoparticles: Influence of the Pore Diameter on Competitive Adsorption and Application to Prostate Cancer Diagnostics

ACS Omega ◽  
2019 ◽  
Vol 4 (5) ◽  
pp. 8852-8861 ◽  
Author(s):  
Carla Vidaurre-Agut ◽  
Eva Rivero-Buceta ◽  
Eva Romaní-Cubells ◽  
Alden M. Clemments ◽  
César David Vera-Donoso ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Competitive Adsorption ◽  
Pore Diameter ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Cancer Diagnostics
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